Pertussis in Massachusetts, 1981-1991: Incidence, Serologic Diagnosis, and Vaccine Effectiveness

Marchant, Colin D.; Loughlin, Anita M.; Lett, Susan M.; Todd, Charles W.; Wetterlow, Leslie H.; Bicchieri, Rex; Higham, Suzanne; Etkind, Paul; Silva, Ellen; Siber, George R.

doi:10.1093/infdis/169.6.1297

Cited by 131 publications

(84 citation statements)

References 18 publications

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“…A specific medium for the culture of B. pertussis was described in 1906 (63), and the demonstration of serum agglutinating antibody for diagnosis was noted in 1916 (635). In the present era, the extensive acellular pertussis vaccine efficacy trials and other epidemiological studies have made it possible to evaluate multiple methods for the laboratory diagnosis of B. pertussis infections (229,293,310,315,317,337,493,536,693,719,722,740,781). Common laboratory diagnostic methods currently include culture, direct antigen detection (direct fluorescent-antibody [DFA] test) PCR, and serologic demonstration (ELISA with many B. pertussis antigens and agglutination) by measuring rises in titer or high single serum values.…”

Section: Specific Diagnosis Of B Pertussis Infectionsmentioning

confidence: 99%

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Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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Section: Specific Diagnosis Of B Pertussis Infectionsmentioning

confidence: 99%

“…However, for those not recently immunized, this problem can be circumvented by using single-serum ELISA. Specifically, patients with illness will have ELISA titers that are significantly higher than GMT, of sera from well controls (493,550).…”

Section: Specific Diagnosis Of B Pertussis Infectionsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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“…13,15 However, recently published data from Australia and the Netherlands suggest that siblings are playing an increasingly important role in the transmission of pertussis to young infants in these countries. [16][17][18] 19 Confirmed and probable cases were included in our analysis for all states except Massachusetts, where only confirmed cases were reported.…”

Section: What's Known On This Subjectmentioning

confidence: 99%

Sources of Infant Pertussis Infection in the United States

et al. 2015

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BACKGROUND: Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when identified, mothers have historically been the most common reservoir of transmission. Despite high vaccination coverage, disease incidence has been increasing. We examined whether infant source of infection (SOI) has changed in the United States in light of the changing epidemiology.

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“…[21][22][23] In the United States, there have been reports of pertussis among adolescents and adults. 24,25 In India, there are no reports of pertussis in adults yet but chances are that these cases are not detected and the susceptibility is also not known.…”

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confidence: 99%

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2017

IJPSR

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Background:Immunization is the most cost-effective intervention for infectious diseases which are the major cause of morbidity and mortality worldwide. There is a scarcity of information on the vaccination status of young adults and the role of socioeconomic conditions in India. Objectives: Present study explored the adult vaccination status and influence of income and education of parents on adult vaccination status in university students from Mumbai, India. Methods: On the basis of the eligibility criterion 149 students were selected for the present study. A total of 8 vaccines namely Tdap/DTP, Varicella, MMR, Influenza, Pneumococcal, Hepatitis A, Hepatitis B and Meningococcal were included in this study for all the respondents. In addition to these vaccines, Human Papilloma Virus vaccine was also included for female respondents. Results: There were total of 149 (75 male and 74 females) respondents with the mean age of 21.5 years. The top 3 immunizations were Td/Tdap (97.3%), MMR (66.4%) and Hepatitis B (55%) among the respondents. Only 4 (5.5%) female respondents have been immunized against the HPV. Conclusions: Td/Tdap (97.3%) and MMR (66.4%) coverage was in line with the recommendations. For all the other vaccines the coverage was low varying from 5.5% to 35.4%. The vaccination coverage was better in respondents with higher educated and higher income parents. We suggest that patient education, planning by government for the implementation of policy for adult vaccination and involvement of physicians are must for better adult vaccination coverage.

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Pertussis in Massachusetts, 1981-1991: Incidence, Serologic Diagnosis, and Vaccine Effectiveness

Cited by 131 publications

References 18 publications

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Sources of Infant Pertussis Infection in the United States

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