Pertussis in Children – Clinical and Epidemiological Characteristics in the Samara Region

Гасилина, Е С; Kitajchik, S. M.; Gorelova, I. A.; Kabanova, N.P.; Fedoseeva, O. A.; Bogoyavlenskaya, I. Yu.; Revtovich, O. M.; Bochkareva, N. M.; Санталова, Г. В.; Frank, Arthur J.

doi:10.22625/2072-6732-2018-10-3-54-60

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…При этом у абсолютного большинства заболевших из привитых (85,94%) интервал от последней прививки до заболевания составил более трех лет, в среднем 9,15 ± 3,37 лет. Похожая ситуация наблюдается и в других регионах РФ [18]. По данным Басова А.А.…”

Section: рисунок 3 сезонные кривые коклюша в воронежской области в 2unclassified

Pertussis in the Voronezh Region: Epidemiology and Vaccination

Mamchik

Gabbasova

Sitnik

et al. 2020

Epidemiology and Vaccinal Prevention

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Relevance. In recent years, the increase in the incidence of pertussis has been observed in many countries despite high vaccination coverage of the child population.Purpose: was to study the epidemiological features of whooping cough in the Voronezh region for the period from 2008 to 2018 years.Methods. The research material was data the annual form No. 2, 5, 6 of Rosstat for 2008 through 2018. Statistical data processing was performed using Microsoft Excel 2007.Results. The epidemiological features of pertussis in the Voronezh region for the period from 2008 to 2018 have been studied. Despite the high coverage of preventive vaccinations in children of the first years of life, in recent years, the incidence of pertussis increased the average Russian rates by 3,5 times. In the age structure of the diseased there was a tendency to increase the proportion of schoolchildren and adults. Analysis of the reports showed that half of the cases were vaccinated at the prescribed age, but the interval after vaccination before the illness was an average of 9 years.Conclusions. In recent years, there has been a tendency to an increase in the incidence of whooping cough in the Voronezh region. The incidence of vaccinated indicates the natural extinction of post-vaccination immunity to school age and requires a decision on the introduction of revaccination of schoolchildren with actual acellular vaccines.

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Section: рисунок 3 сезонные кривые коклюша в воронежской области в 2unclassified

Pertussis in the Voronezh Region: Epidemiology and Vaccination

Mamchik

Gabbasova

Sitnik

et al. 2020

Epidemiology and Vaccinal Prevention

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PCR-based diagnosis of whooping cough in the Russian Federation

et al. 2021

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The aim was to determine how often the PCR method is used in different laboratories in Russia. In 2018, we conducted a questionnaire survey in diagnostic laboratories of medical organizations and the Centers of Hygiene and Epidemiology that performed PCR studies to identify microorganisms of the genus Bordetella in all 85 Russian regions. We found that in 2013 the PCR was used in 33 (38.8%) regions, but in 2017 the number of regions increased to 64 (75.3%). During 2013-2017 the study has not been applied in 21 regions. The number of PCR tests performed in the laboratories of medical organizations was significantly different. There has been an increase in the number of tests for the diagnosis of pertussis among people with clinical signs of infection and among contact persons in foci of infection. Compared to the Centers of Hygiene and Epidemiology, in medical organizations the rate of introduction of the PCR was higher. Between 2013 and 2017 the proportion of samples containing DNA B.pertussis decreased, but the proportion of samples containing DNA of other representatives of the genus Bordetella increased. Moreover, in the case of isolation DNA Bordetella spp. clinicians diagnose «Whooping cough, other unspecified organism», since there is no information on the species of the pathogen. Thus, in order to improve the diagnosis of pertussis, it is necessary to optimize PCR tests by including target genes that allow to identify of currently relevant DNAs of different representatives of the genus Bordetella.

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Clinical-epidemiological aspects of whooping cough in children in conditions of mass vaccinoprophylactics

Бабаченко¹,

Нестерова²,

Чернышова

et al. 2019

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The aim of the study was to present clinical, epidemiological and laboratory characteristics of modern pertussis in hospitalized children, as well as to assess the frequency of pertussis infection as an etiological factor of long – term cough in children and adolescents.Materials and methods: medical records of 545 patients hospitalized in Children’s city clinical hospital №5 named after N.F. Filatov (Saint-Petersburg) in the period 2015–2017 were analyzed. Detailed clinical and laboratory analysis with subsequent follow-up of patients was carried out in 80 patients with pertussis aged 1 month to 18 years. The DNA of the causative agents of pertussis infection was identified by PCR using a commercial kit “AmpliSens Bordetella multi-FL” (Moscow); parallel was determined the bacterial load by quantitative PCRRT (real time) using test systems production, Gamaleya Research Institute of Epidemiology and Microbiology (Moscow), allowing to detect a single genome-equivalents (GE) of B. pertussis in smears from the nasopharynx. Pertussis convalescents were examined 1, 3 and 6 months after discharge.Results. Among hospitalized children dominated the first 2 years of life (70.8%), 78% were unvaccinated children. The sources of infection for children of the first two years of life were family members in 77% of cases, for preschoolers-in 67%, for schoolchildren-in 14%. Patients of moderate severity were 81.1%, severe – 10.3%; mild – 7%. Of the specific complications, respiratory rhythm disturbances were notedin 11.6%, including respiratory arrest-in 2.8%; pneumonia of mixed etiology was recorded in 6.2% of cases. Introduction of PCR method allows to increase laboratory confirmation up to 87.2%. In 63.6% of cases pertussis of pertussis were detected by PCR genome-equivalents of DNA in 6 months from hospital discharge. In patients with long – term cough, pertussis wand DNA was detected in preschool children in 11.14% of cases, in patients 7–12 years – in 25.93%, in adolescents-in 20% of cases.Conclusion. Whooping cough is a common infection among schoolchildren and adolescents, despite the high coverage of young children with preventive vaccinations. Pertussis convalescents can release the DNA of the pathogen for a long time, which may have epidemiological significance for unvaccinated and those children and adults, who have lost postvaccinal immunity, in the foci of infection.

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Pertussis in Children – Clinical and Epidemiological Characteristics in the Samara Region

Cited by 6 publications

References 2 publications

Pertussis in the Voronezh Region: Epidemiology and Vaccination

Pertussis in the Voronezh Region: Epidemiology and Vaccination

PCR-based diagnosis of whooping cough in the Russian Federation

Clinical-epidemiological aspects of whooping cough in children in conditions of mass vaccinoprophylactics

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