Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type

Lee, Min Jung; Kang, Mi Jin; Lee, So Yeon; Lee, Eun; Kim, Kangjin; Won, Sungho; Suh, Dong In; Kim, Kyung Won; Sheen, Youn Ho; Ahn, Kangmo; Kim, Bong Soo; Hong, Soo Jong

doi:10.1016/j.jaci.2017.11.045

Cited by 121 publications

(113 citation statements)

References 47 publications

(63 reference statements)

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“…The higher relative abundance of bifidobacteria in FCT BiH was accompanied and amplified by a higher microbial load. Recently, it was shown that the bacterial cell amounts were decreased in the 6-month feces of infants with atopic dermatitis (51). In a follow-up study of Estonian and Swedish children who were sampled over the first year of life, a consistent lower level of Bifidobacterium in stools was associated with the development of allergy (52).…”

Section: Discussionmentioning

confidence: 99%

Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics

Berger

Porta

Foata

et al. 2020

mBio

119

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Human milk oligosaccharides (HMOs) may provide health benefits to infants partly by shaping the development of the early-life intestinal microbiota. In a randomized double-blinded controlled multicentric clinical trial, healthy term infants received either infant formula (control) or the same formula with two HMOs (2′-fucosyllactose and lacto-N-neotetraose; test) from enrollment (0 to 14 days) to 6 months. Then, all infants received the same follow-up formula without HMOs until 12 months of age. Breastfed infants (BF) served as a reference group. Stool microbiota at 3 and 12 months, analyzed by 16S rRNA gene sequencing, clustered into seven fecal community types (FCTs) with marked differences in total microbial abundances. Three of the four 12-month FCTs were likely precursors of the adult enterotypes. At 3 months, microbiota composition in the test group (n = 58) appeared closer to that of BF (n = 35) than control (n = 63) by microbiota alpha (within group) and beta (between groups) diversity analyses and distribution of FCTs. While bifidobacteriaceae dominated two FCTs, its abundance was significantly higher in one (FCT BiH for Bifidobacteriaceae at high abundance) than in the other (FCT Bi for Bifidobacteriaceae). HMO supplementation increased the number of infants with FCT BiH (predominant in BF) at the expense of FCT Bi (predominant in control). We explored the association of the FCTs with reported morbidities and medication use up to 12 months. Formula-fed infants with FCT BiH at 3 months were significantly less likely to require antibiotics during the first year than those with FCT Bi. Previously reported lower rates of infection-related medication use with HMOs may therefore be linked to gut microbiota community types. (This study has been registered at ClinicalTrials.gov under registration number NCT01715246.) IMPORTANCE Human milk is the sole and recommended nutrition for the newborn infant and contains one of the largest constituents of diverse oligosaccharides, dubbed human milk oligosaccharides (HMOs). Preclinical and clinical association studies indicate that HMOs have multiple physiological functions largely mediated through the establishment of the gut microbiome. Until recently, HMOs were not available to investigate their role in randomized controlled intervention trials. To our knowledge, this is the first report on the effects of 2 HMOs on establishing microbiota in newborn infants. We provide a detailed description of the microbiota changes observed upon feeding a formula with 2 HMOs in comparison to breastfed reference infants' microbiota. Then, we associate the microbiota to long-term health as assessed by prescribed antibiotic use.

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Section: Discussionmentioning

confidence: 99%

Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics

Berger

Porta

Foata

et al. 2020

mBio

119

131

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“…Apart from probiotics, alterations in the gut microbiome might affect the development of host immune cell function through differences in gut microbiome genes, particularly in infants with AD. 24 …”

Section: How Do Gut Microbiome Impact Ad?mentioning

confidence: 99%

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

Lee

Park

2018

Allergy Asthma Immunol Res

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The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD.

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“…There is growing knowledge of the importance of mutual interaction between microbiota and host immune system. Microbiota plays a key role in the development of newborn immune system when relatively sterile newborn is becoming gradually colonized by a broad spectra of microorganisms . Microbiota becomes stable at the age of 2–3 years , therefore early intervention targeting modification of microbiota composition will be more likely successful and easier than correcting the dysbiosis in adulthood.…”

Section: Introductionmentioning

confidence: 99%

Decreased allergy incidence in children supplemented with E. coli O83:K24:H31 and its possible modes of action

et al. 2018

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The growing knowledge of the key role of microbiota in the maturation of neonatal immune system suggests that manipulation of microbiota could be exploited in hampering allergy development. In this study, Escherichia coli O83:K24:H31 (EcO83) was administered to newborns that were followed prospectively. Several immunological characteristics (cytokines, specific IgE, total T regulatory cells (Treg) and subpopulation of natural Treg (nTreg) and induced Treg (iTreg)) were tested in peripheral blood of 8-year-old children. Incidence of allergic disease was decreased in EcO83 supplemented children and significantly elevated levels of IL-10 and IFN-ɣ were detected in serum of EcO83 supplemented children. Probiotic supplementation did not influence the numbers of the total Treg population but their functional capacity (intracellular expression of IL-10) was significantly increased in children supplemented with EcO83 in comparison to nonsupplemented children. Morover, decreased proportion of iTreg was present in peripheral blood of non-supplemented in comparison to EcO83 supplemented children. Finally, stimulation of cord blood cells with EcO83 promoted both gene expression and secretion of IL-10 and IFN-ɣ suggesting that beneficial effect of EcO83 in prevention of allergy development could be mediated by promotion of regulatory responses (by IL-10) and Th1 immune response (by IFN-ɣ). Keywords: allergy r cord blood r E. coli r probiotics r Treg Additional supporting information may be found online in the Supporting Information section at the end of the article. , L. et al., Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur. J. Immunol. 2017. 47: 1584-1797. Abbreviations: CBMC: cord blood mononuclear cells · CFU: colony forming units · EcO83: Escherichia coli O83:K24:H31 · IQR: interquartile range · nTreg: natural Treg · Treg: T regulatory cells · iTreg: induced Treg

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Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type

Abstract: Alterations in the gut microbiome can be associated with AD because of different bacterial genes that can modulate host immune cell function.

Cited by 121 publications

References 47 publications

Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics

Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

Decreased allergy incidence in children supplemented with E. coli O83:K24:H31 and its possible modes of action

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