Perturbation of the T-Cell Repertoire in Patients With Unstable Angina

Liuzzo, Giovanna; Kopecky, Stephen L.; Frye, Robert L.; O’Fallon, W. Michael; Maseri, Attilio; Goronzy, Jörg J.; Weyand, Cornelia M.

doi:10.1161/01.cir.100.21.2135

Cited by 361 publications

(316 citation statements)

References 19 publications

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“…CD28 Ϫ CD4 T cells have been reported to play a role in rheumatoid arthritis and acute coronary syndromes (17,34). As these cells frequently expressed KIR (Fig.…”

Section: Cd4 T Cells Express a Distinct Kir Repertoirementioning

confidence: 95%

Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors

Bergen

Thompson

Slik

et al. 2004

The Journal of Immunology

110

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Killer Ig-like receptors (KIR) are commonly found on human NK cells, γδ T cells, and CD8 T cells. Although KIR+ CD4 T cells are found in certain patients, their prevalence in healthy donors is controversial. We now provide definitive proof that such cells are present in most individuals, and report on their frequency, surface phenotype, cytokine profile, and Ag specificity. The number of KIR+ CD4 T cells detected in peripheral blood increased with age. In contrast with regular KIR− CD4 T cells, the majority of KIR+ CD4 T cells lacked surface expression of CD27, CD28, CCR4, and CCR7, but did express CD57 and 2B4. In addition, KIR were detected on approximately one-tenth of CD28− and CD57+ memory CD4 T cells. In line with the absence of the Th2 marker CCR4, the KIR+ CD4 cells produced mainly IFN-γ and little IL-4, IL-10, or IL-17 upon TCR triggering. Furthermore, the KIR+ population contained cells that responded to recall Ags in an HLA class II-restricted fashion. Together, our data indicate that KIR-expressing CD4 T cells are predominantly HLA class II-restricted effector memory Th1 cells, and that a significant, previously unrecognized fraction of effector memory Th1 cells expresses KIR.

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“…CD28 Ϫ CD4 T cells have been reported to play a role in rheumatoid arthritis and acute coronary syndromes (17,34). As these cells frequently expressed KIR (Fig.…”

Section: Cd4 T Cells Express a Distinct Kir Repertoirementioning

confidence: 95%

Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors

Bergen

Thompson

Slik

et al. 2004

The Journal of Immunology

110

View full text Add to dashboard Cite

show abstract

“…[4][5][6][7] Recently, the association of pathogenic T cells with acute coronary syndrome in humans was addressed. [8][9][10] However, it remains unclear which specific subpopulation of T cells plays a major role in acute coronary syndrome. CD4 1 CD28 null T cells have been reported to contribute to acute coronary syndrome, 11,12 and expansion of CD4 1 CD28 null T cells is strongly associated with the recurrence of acute coronary events.…”

Section: Introductionmentioning

confidence: 99%

Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction

Youn

Lee

et al. 2014

Cell Mol Immunol

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Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction (MI). We studied the immunological characteristics and clinical impact of CD8 1 CD57 1 T cells in acute MI patients. The frequency of CD57 1 cells among CD8 1 T cells was examined in peripheral blood sampled the morning after acute MI events. Interestingly, the frequency of CD57 1 cells in the CD8 1 T-cell population correlated with cardiovascular mortality 6 months after acute MI. The immunological characteristics of CD8 1 CD57 1 T cells were elucidated by surface immunophenotyping, intracellular cytokine staining and flow cytometry. Immunophenotyping revealed that the CD8 1 CD57 1 T cells were activated, senescent T cells with pro-inflammatory and tissue homing properties. Because a high frequency of CD8 1 CD57 1 T cells is associated with short-term cardiovascular mortality in acute MI patients, this specific subset of CD8 1 T cells might contribute to acute coronary events via their pro-inflammatory and high cytotoxic capacities. Identification of a pathogenic CD8 1 T-cell subset expressing CD57 may offer opportunities for the evaluation and management of acute MI.

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“…Moreover, CD28– T cells were shown to produce the cytotoxic molecules perforin and granzyme B, which resulted in cytolysis of the endothelium in vitro 29, 30. CD4+CD28– T cells have been found in patients with cerebrovascular and cardiovascular diseases such as acute coronary syndrome27, 31 and stroke 32, 33, 34. Of note, in these patients this proinflammatory cytokine production is upregulated by the costimulatory receptors OX40 and CD137 on circulating CD4+CD28– T cells,25 which were also found to be located in atherosclerotic plaques preferentially accumulating in unstable lesions 35.…”

Section: Discussionmentioning

confidence: 99%

Increased Soluble CD137 Levels and CD4+ T‐Cell‐Associated Expression of CD137 in Acute Atherothrombotic Stroke

et al. 2018

Clinical Translational Sci

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As a proinflammatory cytokine, CD137 (4‐1BB, TNFRSF9) is present in membrane‐bound and soluble forms. Increased expression of CD137 was recently found in T cells in human atherosclerotic plaques. However, the exact role of CD137 in ischemic stroke is not clear. In this study we analyzed the protein levels of soluble CD137 (sCD137) and the expression of CD137 on CD4+ T cells in the peripheral blood of patients with acute atherothrombotic stroke by using the cytometry beads array (CBA) and flow cytometry. Within 24 hours of onset, the stroke patients showed elevated levels of sCD137 (2.7 pg/ml) and CD137 expression on CD4+ T cells (4.9 ± 3.2%) compared with normal controls (1.1 pg/ml, P < 0.01; 1.3 ± 1.0%, P < 0.01). Alterations in CD137 expression may enhance ischemia‐induced inflammatory responses via bidirectional signaling and, consequently, aggravate brain injury in early stages of this disorder.

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Perturbation of the T-Cell Repertoire in Patients With Unstable Angina

Cited by 361 publications

References 19 publications

Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors

Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors

Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction

Increased Soluble CD137 Levels and CD4+ T‐Cell‐Associated Expression of CD137 in Acute Atherothrombotic Stroke

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