Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction

Yu, Hee Tae; Youn, Jong Chan; Lee, Jino; Park, Seung-Hyun; Seok, Ho; Lee, Jungsul; Choi, Chulhee; Park, Sungha; Choi, Donghoon; Ha, Jong Won; Shin, Eui‐Cheol

doi:10.1038/cmi.2014.74

Cited by 77 publications

(36 citation statements)

References 34 publications

(41 reference statements)

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“…CD57 ? senescent T cells has been correlated with poor outcome after acute myocardial infarction [78]. Moreover, several studies have reported that in patients with acute coronary syndrome, statins, which are HMG-CoA reductase inhibitors, decrease the frequency of circulating CD4 ?…”

Section: Senescent T Cells In Atherosclerosis and Coronary Artery Dismentioning

confidence: 99%

T cell senescence and cardiovascular diseases

Park

Shin

et al. 2015

Clin Exp Med

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Age-related changes in the immune system, commonly termed "immunosenescence," contribute to deterioration of the immune response and fundamentally impact the health and survival of elderly individuals. Immunosenescence affects both the innate and adaptive immune systems; however, the most notable changes are in T cell immunity and include thymic involution, the collapse of T cell receptor (TCR) diversity, an imbalance in T cell populations, and the clonal expansion of senescent T cells. Senescent T cells have the ability to produce large quantities of proinflammatory cytokines and cytotoxic mediators; thus, they have been implicated in the pathogenesis of many chronic inflammatory diseases. Recently, an increasing body of evidence has suggested that senescent T cells also have pathogenic potential in cardiovascular diseases, such as hypertension, atherosclerosis, and myocardial infarction, underscoring the detrimental roles of these cells in various chronic inflammatory responses. Given that cardiovascular disease is the number one cause of death worldwide, there is great interest in understanding the contribution of age-related immunological changes to its pathogenesis. In this review, we discuss general features of age-related alterations in T cell immunity and the possible roles of senescent T cells in the pathogenesis of cardiovascular disease.

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Section: Senescent T Cells In Atherosclerosis and Coronary Artery Dismentioning

confidence: 99%

T cell senescence and cardiovascular diseases

Park

Shin

et al. 2015

Clin Exp Med

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“…CMV is associated to the expansion of CD8+ CD57+ T cells [8,9] that have independently been related to coronary artery disease [57]. In addition, high frequencies of these cells are associated with short-term mortality in patients with acute myocardial infarctions [58].…”

Section: Immunosenescence CMV and Cardiovascular Diseasementioning

confidence: 99%

Immunosenescence: Implications for response to infection and vaccination in older people

et al. 2015

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“…CD57 seems to play various roles in differentiation of the neural crest and lymphocytes (see the “Introduction”). In the same context, the antibody is available as a marker of inactive or senescent T lymphocytes [ 14 ] as well as of specific lymphocytes involved in the initial stage of atherosclerosis [ 15 16 ] and myocardial infarction [ 17 ]. Unfortunately, we failed CD8 immunostaining of the present materials (see the final sentence of “Materials and Methods”).…”

Section: Discussionmentioning

confidence: 99%

CD57 (Leu-7, HNK-1) immunoreactivity seen in thin arteries in the human fetal lung

et al. 2018

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CD57 (synonyms: Leu-7, HNK-1) is a well-known marker of nerve elements including the conductive system of the heart, as well as natural killer cells. In lung specimens from 12 human fetuses at 10–34 weeks of gestation, we have found incidentally that segmental, subsegmental, and more peripheral arteries strongly expressed CD57. Capillaries near developing alveoli were often or sometimes positive. The CD57-positive tissue elements within intrapulmonary arteries seemed to be the endothelium, internal elastic lamina, and smooth muscle layer, which corresponded to tissue positive for a DAKO antibody reactive with smooth muscle actin we used. However, the lobar artery and pulmonary arterial trunk as well as bronchial arteries were negative. Likewise, arteries in and along any abdominal viscera, as well as the heart, thymus, and thyroid, did not express CD57. Thus, the lung-specific CD57 reactivity was not connected with either of an endodermal- or a branchial arch-origin. CD57 antigen is a sugar chain characterized by a sulfated glucuronic acid residue that is likely to exist in some glycosphingolipids. Therefore, a chemical affinity or an interaction might exist between CD57-positive arterioles and glycosphingolipids originating from alveoli, resulting in acceleration of capillary budding to make contact with the alveolar wall. CD57 might therefore be a functional marker of the developing air-blood interface that characterizes the fetal lung at the canalicular stage.

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Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction

Cited by 77 publications

References 34 publications

T cell senescence and cardiovascular diseases

T cell senescence and cardiovascular diseases

Immunosenescence: Implications for response to infection and vaccination in older people

CD57 (Leu-7, HNK-1) immunoreactivity seen in thin arteries in the human fetal lung

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