PERSYVE: design and validation of a questionnaire about adverse effects of antihypertensive drugs

Duarte-Silva, Daniela; Figueiras, Adolfo; Herdeiro, María Teresa; Rodrigues, António Teixeira; Branco, Fábio; Polónia, Jorge; Figueiredo, Isabel V.

doi:10.4321/s1886-36552014000200005

Cited by 9 publications

(8 citation statements)

References 30 publications

(38 reference statements)

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“…Previous research has shown that questionnaires can be useful instruments in obtaining information from patients about adverse events and about, for instance, the time course, severity, and outcome of the adverse events [15,16]. Even though researchers have developed several questionnaires in the past [15][16][17], they were developed for other types of drugs and are not suitable for radiopharmaceuticals because of aspects that are unique to the use of these products in nuclear medicine departments. Examples are the specific preparation of the patient before the nuclear medicine examination or additional steps during the procedure such as physical exercise or the concomitant administration of interventional agents, like agents that induce stress in the case of the assessment of myocardial perfusion.…”

Section: Introductionmentioning

confidence: 99%

Patient-Reported Adverse Events of Radiopharmaceuticals: Development and Validation of a Questionnaire

et al. 2020

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Introduction Radiopharmaceuticals may cause adverse events. Knowledge about adverse events from a patient's perspective could help healthcare professionals to detect, understand, and manage adverse events more efficiently when using radiopharmaceuticals. Researchers need a validated questionnaire that can be used in patients to assess adverse events with radiopharmaceuticals. Objective The aim of this study was to develop, validate the content of, and perform initial testing of a questionnaire assessing patient-reported adverse events of radiopharmaceuticals. Methods Based on existing literature, six professionals drafted and evaluated a first version of the questionnaire. Further content validation was performed using cognitive interviews with six patients undergoing a nuclear medicine examination. After adaptations, the questionnaire was developed into a web-based questionnaire. One hundred patients undergoing nuclear examination tested this version, and the results were used to assess its acceptability and evaluate reported adverse events. Results Questions and answer options were revised in the initial questionnaire to improve clarity. In addition, some questions were removed. The final version consisted of 18 questions. In the test phase, the acceptability of the questionnaire was demonstrated (e.g. 79% of the patients who received the questionnaire completed it, and the median time to complete the questionnaire was 12 min for patients who reported an adverse event). Of the 100 patients (53% men, median age 64 years), 12 reported a total of 22 adverse events. One of these adverse events had a high causal association. Conclusion After validation and testing, the developed questionnaire to study patient-reported adverse events of radiopharmaceuticals is a suitable and valid instrument which can be used in future research.

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Section: Introductionmentioning

confidence: 99%

Patient-Reported Adverse Events of Radiopharmaceuticals: Development and Validation of a Questionnaire

et al. 2020

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“…It varies from 0 to 1, and shows the extent to which all the ingredients of the test measure the same concept. For an instrument with variables with a nominal/ordinal outcomes (such as a 1-7 Likert scale), it is acceptable to obtain Cronbach's alpha values above 0.7 (21,22). Secondly, the questionnaire was divided randomly into two parts with the same number of questions, and Cronbach's alpha for each part was Acta facultatis medicae Naissensis 2016;33(4):247-258 251 Unauthenticated Download Date | 5/13/18 3:52 AM calculated.…”

Section: Reliability Testingmentioning

confidence: 99%

“…The review ended with 15 questions which were comprised by the final instrument. Pilot testing of the questionnaire was performed with 7 pharmacists and 30 patients on statin therapy, by the same researcher, to evaluate the clarity and comprehension (22). The results of the pilot testing were not taken into account when processing data for the validation of the questionnaire.…”

Section: Construction Of the Questionnairementioning

confidence: 99%

“…The variables to be measured by this questionnaire were: age (the data was divided into four groups: 18-29 years of age, 30-49, 50-65, and over 65 years), gender (male and female), education level (years of schooling were divided into five groups: ≤4, 8, 12, 16, ≥17), level of monthly income (wages), main diagnosis, comorbidity, and duration of statin therapy (22,23).…”

Section: Acta Facultatis Medicaementioning

confidence: 99%

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Developmentand Validation of a Questionnaire about Patient Knowledge of Adverse Effects of Statins

Valentina¹,

Slobodan²,

Stanić³

et al. 2016

Acta Facultatis Medicae Naissensis

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The questionnaire showed satisfactory internal consistency, with Cronbach's alpha of 0.898, good construction and homogeneity of questions. After splitting the questionnaire to two parts at random, Cronbach's alphas were 0.834 and 0.842 for the both parts, respectively. Exploratory factorial analysis revealed two domains. The patients rated their knowledge of the side effects of statins 52.7±19.9 on the visual analogue scale.Based on the results of this study, we believe that this questionnaire could be a useful tool for testing the knowledge of patients about adverse effects of statins and help physicians to identify patients with insufficient knowledge who should be additionally informed about it.

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“…Moreover, the undesirable effects of antihypertensive drugs may also interfere with the quality of life of patients and lead to a limited therapeutic adherence. (9) In addition, effects of the disease itself on the quality of life can generate emotional impacts on people's lives, and make them give up the medication, see no reasons for medication intake, do not realize advances in treatment, think a lot about the limitations or do not realize improvement in their behavior. Therefore, it is easy to notice the complex interaction between quality of life in hypertensive patients and medication adherence, which should be better understood by health professionals.…”

Section: Introductionmentioning

confidence: 99%

Qualidade de vida e adesão medicamentosa para pessoas hipertensas

2016

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Objective: To analyze the correlation between medication adherence and quality of life for hypertensive people attended at Basic Health Units (UBS -Unidade Básica de Saúde). Methods: Cross-sectional analytical study with a random and representative sample. The correlation between quality of life and medication adherence was evaluated by using the Minichal Brazil and the Morisky scale of medication adherence. Results: The study included 720 people monitored in 13 Basic Health Units. The mean age was 62.5 years old. The Spearman's coefficient revealed an inverse (Rho = -0.130) and statistically significant (p = 0.001) correlation of low magnitude. Conclusion: The inverse correlation means that greater adherence (higher scores of Morisky scale) equals better quality of life (lower scores of Brazil Minichal scale). The weak correlation between quality of life and medication adherence reinforces the idea that quality of life for hypertensive people is related to other factors, suggesting further research. ResumoObjetivo: Analisar a correlação entre adesão medicamentosa e qualidade de vida para pessoas hipertensas assistidas em Unidades Básicas de Saúde. Métodos: Estudo transversal, analítico, com amostra aleatória e representativa. Avaliou-se a correlação entre qualidade de vida e adesão medicamentosa, utilizando-se o Minichal Brasil e a escala Morisky de adesão medicamentosa. Resultados: Participaram do estudo 720 pessoas, acompanhadas em 13 Unidades Básicas de Saúde. A média de idade foi de 62,5 anos. O coeficiente de Spearman revelou uma correlação inversa (Rho = -0,130) e estatisticamente significante (p=0,001), de fraca magnitude. Conclusão: A correlação inversa significa que maior adesão (maiores escores na escala Morisky) equivale a melhor qualidade de vida (menores escores da escala Minichal Brasil). A fraca correlação entre qualidade de vida e adesão medicamentosa reforça a ideia de que qualidade de vida para hipertensos está relacionada a outros fatores, sugerindo novas investigações.

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PERSYVE: design and validation of a questionnaire about adverse effects of antihypertensive drugs

Cited by 9 publications

References 30 publications

Patient-Reported Adverse Events of Radiopharmaceuticals: Development and Validation of a Questionnaire

Patient-Reported Adverse Events of Radiopharmaceuticals: Development and Validation of a Questionnaire

Developmentand Validation of a Questionnaire about Patient Knowledge of Adverse Effects of Statins

Qualidade de vida e adesão medicamentosa para pessoas hipertensas

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