Perspectives on testicular germ cell neoplasms

Liu, Cheng; Lyu, Bingjian; Roth, Lawrence M.

doi:10.1016/j.humpath.2016.08.002

Cited by 57 publications

(51 citation statements)

References 65 publications

(58 reference statements)

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“…In more than 80% of postpubertal testicular GCT, a consistent chromosomal abnormality, isochromosome 12p (i12p), can be detected. The i12p‐negative tumors usually display gains of chromosome 12p . Type III GCT occurs in adults over the age of 50 years and represents spermatocytic tumors.…”

Section: Introductionmentioning

confidence: 99%

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Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors

Greimelmaier¹,

Calaminus

Kristiansen

et al. 2019

Pediatric Blood & Cancer

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Background Pediatric germ cell tumors (GCT) are rare and very heterogeneous neoplasms that show a high diversity in tumor biology and histology. The clinical behavior cannot be predicted based on morphology or immunohistochemistry. The aim of this study was to investigate a large number of pediatric GCT regarding chromosomal gains of 12p and 1q. Methods One hundred and eighty pediatric nonseminomatous GCT, that is, mature teratomas, immature teratomas, yolk sac tumors, and mixed germ cell tumors, from three age groups were evaluated for 1q and 12p gains by fluorescence in situ hybridization in tissue micro arrays. The results were correlated with tumor biology and clinical data. Results Eleven out of 143 GCT showed gains of 1q. In 29/157 GCT a gain of 12p was found. Prepubertal patients (≤6 years of age) more often displayed gains of 1q compared to pubertal/adolescent patients (11‐17 years of age), whereas pubertal/adolescent patients showed gains of 12p most frequently. Twenty‐one out of 155 patients suffered from relapse or metachronous disease. Patients with and without gains of 1q or 12p did not differ in frequency of these events. However, the likelihood of occurrence of these clinical events varied depending on the histological type of the tumor. Conclusion The biological behavior of pediatric GCT depends more on the histological type of the tumor than on the genetic aberrations examined in this study. Gains of 1q and 12p are not suitable to predict the clinical outcome of GCT in childhood. Nevertheless, both genetic alterations might be used as biomarkers to distinguish different histological types of GCT and therefore could be of diagnostic value, especially in borderline cases.

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Section: Introductionmentioning

confidence: 99%

“…The i12p-negative tumors usually display gains of chromosome 12p. 3,[8][9][10] Type III GCT occurs in adults over the age of 50 years and represents spermatocytic tumors.…”

Section: Introductionmentioning

confidence: 99%

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors

Greimelmaier¹,

Calaminus

Kristiansen

et al. 2019

Pediatric Blood & Cancer

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“…Teratoma is a germ cell tumor occurring mainly in the testis and ovary but also less commonly in the mediastinum and other organs . Teratomas are characterized by the presence of various mature or immature tissue types, for example, brain, squamous or respiratory epithelium, thyroid tissue, brain, cartilage or bone .…”

Section: Discussionmentioning

confidence: 99%

MALDI Imaging for Proteomic Painting of Heterogeneous Tissue Structures

Kriegsmann¹,

Kriegsmann

Kriegsmann³

et al. 2018

Proteomics Clinical Apps

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Purpose To present matrix‐assisted laser desorption/ionization (MALDI) imaging as a powerful method to highlight various tissue compartments. Experimental design Formalin‐fixed paraffin‐embedded (FFPE) tissue of a uterine cervix, a pancreas, a duodenum, a teratoma, and a breast cancer tissue microarray (TMA) are analyzed by MALDI imaging and by immunohistochemistry (IHC). Peptide images are visualized and analyzed using FlexImaging and SCiLS Lab software. Different histological compartments are compared by hierarchical cluster analysis. Results MALDI imaging highlights tissue compartments comparable to IHC. In cervical tissue, normal epithelium can be discerned from intraepithelial neoplasia. In pancreatic and duodenal tissues, m/z signals from lymph follicles, vessels, duodenal mucosa, normal pancreas, and smooth muscle structures can be visualized. In teratoma, specific m/z signals to discriminate squamous epithelium, sebaceous glands, and soft tissue are detected. Additionally, tumor tissue can be discerned from the surrounding stroma in small tissue cores of TMAs. Proteomic data acquisition of complex tissue compartments in FFPE tissue requires less than 1 h with recent mass spectrometers. Conclusion and clinical relevance The simultaneous characterization of morphological and proteomic features in the same tissue section adds proteomic information for histopathological diagnostics, which relies at present on conventional hematoxylin and eosin staining, histochemical, IHC and molecular methods.

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“…MGCTs are malignant tumors that contain more than one germ cell component or histologic subtypes of all germ cell tumors; the most malignant governs the prognosis (3,70,75,78). The average patient age at presentation is 30 years, and although any cell type combination is possible, embryonal carcinoma is the most common component and is often combined with one or more components (teratoma, seminoma, yolk sac tumor, and choriocarcinoma).…”

Section: Mixed Germ Cell Tumorsmentioning

confidence: 99%

Spectrum of Extratesticular and Testicular Pathologic Conditions at Scrotal MR Imaging

et al. 2018

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Diagnostic workup of scrotal lesions should begin with a complete clinical history and physical examination, including analysis of risk factors such as family history of testicular cancer, personal history of tumor in the contralateral testis, and cryptorchidism, followed by imaging. Scrotal ultrasonography (US) with a combination of gray-scale and color Doppler techniques has been the first-line imaging modality for evaluation of testicular and extratesticular lesions because of its low cost, wide availability, and high diagnostic accuracy. However, US has limitations related to operator dependence, the relatively small field of view, and lack of tissue characterization. Magnetic resonance (MR) imaging, because of its superior soft-tissue contrast and multiplanar capabilities, is increasingly being used as a supplemental diagnostic problem-solving tool in cases where scrotal US findings are inconclusive or nondiagnostic. In addition to morphology, lesion location, and tissue characterization (eg, fat, blood products, granulation tissue, and fibrosis), scrotal MR imaging provides important information that can affect surgical planning and improve patient care. MR imaging also is helpful for differentiating testicular and extratesticular lesions, distinguishing between benign and malignant lesions, and evaluating the local extent of disease. This review discusses the anatomy and MR imaging features of testicular and extratesticular neoplastic and nonneoplastic conditions and describes relevant MR imaging techniques. RSNA, 2018 Contact information that appeared in the print version of this article was updated in the online version on May 14, 2018.

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Perspectives on testicular germ cell neoplasms

Cited by 57 publications

References 65 publications

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors

MALDI Imaging for Proteomic Painting of Heterogeneous Tissue Structures

Spectrum of Extratesticular and Testicular Pathologic Conditions at Scrotal MR Imaging

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