Perspectives on Auditory Translational Research

Prell, Colleen G. Le; Lobariñas, Edward

doi:10.1007/978-3-319-40848-4_1

Cited by 4 publications

(6 citation statements)

References 64 publications

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“…Reported relations of SPiN to occupational noise exposure are complicated by the possible influence of audiometric deficits ( Alvord, 1983 ; Kumar et al., 2012 ; Hope et al., 2013 ). Two small studies of college students found no relation of noise exposure to SPiN ( Le Prell and Lobarinas, 2016 ; Grinn et al., 2017 ). In a third, noise exposure was associated with poorer SPiN, but at a low sound level unlikely to emphasize low-SR fibers ( Liberman et al., 2016 ).…”

Section: Discussionmentioning

confidence: 98%

Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

Guest¹,

Munro²,

Prendergast³

et al. 2018

Hearing Research

151

134

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In rodents, noise exposure can destroy synapses between inner hair cells and auditory nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced cochlear synaptopathy usually leaves cochlear thresholds unaltered, but is associated with long-term reductions in auditory brainstem response (ABR) amplitudes at medium-to-high sound levels. This pathophysiology has been suggested to degrade speech perception in noise (SPiN), perhaps explaining why SPiN ability varies so widely among audiometrically normal humans. The present study is the first to test for evidence of cochlear synaptopathy in humans with significant SPiN impairment. Individuals were recruited on the basis of self-reported SPiN difficulties and normal pure tone audiometric thresholds. Performance on a listening task identified a subset with “verified” SPiN impairment. This group was matched with controls on the basis of age, sex, and audiometric thresholds up to 14 kHz. ABRs and envelope-following responses (EFRs) were recorded at high stimulus levels, yielding both raw amplitude measures and within-subject difference measures. Past exposure to high sound levels was assessed by detailed structured interview. Impaired SPiN was not associated with greater lifetime noise exposure, nor with any electrophysiological measure. It is conceivable that retrospective self-report cannot reliably capture noise exposure, and that ABRs and EFRs offer limited sensitivity to synaptopathy in humans. Nevertheless, the results do not support the notion that noise-induced synaptopathy is a significant etiology of SPiN impairment with normal audiometric thresholds. It may be that synaptopathy alone does not have significant perceptual consequences, or is not widespread in humans with normal audiograms.

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Section: Discussionmentioning

confidence: 98%

Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

Guest¹,

Munro²,

Prendergast³

et al. 2018

Hearing Research

151

134

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“…However, stimuli were presented at 35 dB HL, again suggesting minimal contributions of low-SR fibers to performance as at this sound intensity the high-SR fibers are unlikely to be saturated and thus efficient coding is not primarily dependent on low-SR fibers. Le Prell and Lobarinas (2016) examined measures of recreational noise exposure for groups of audiometrically normal young people, divided based on performance on a measure of word recognition in noise. The groups did not differ significantly in preferred listening level, nor in number of sources of high-level noise they were exposed to.…”

Section: Introductionmentioning

confidence: 99%

Effects of noise exposure on young adults with normal audiograms II: Behavioral measures

et al. 2017

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An estimate of lifetime noise exposure was used as the primary predictor of performance on a range of behavioral tasks: frequency and intensity difference limens, amplitude modulation detection, interaural phase discrimination, the digit triplet speech test, the co-ordinate response speech measure, an auditory localization task, a musical consonance task and a subjective report of hearing ability. One hundred and thirty-eight participants (81 females) aged 18–36 years were tested, with a wide range of self-reported noise exposure. All had normal pure-tone audiograms up to 8 kHz. It was predicted that increased lifetime noise exposure, which we assume to be concordant with noise-induced cochlear synaptopathy, would elevate behavioral thresholds, in particular for stimuli with high levels in a high spectral region. However, the results showed little effect of noise exposure on performance. There were a number of weak relations with noise exposure across the test battery, although many of these were in the opposite direction to the predictions, and none were statistically significant after correction for multiple comparisons. There were also no strong correlations between electrophysiological measures of synaptopathy published previously and the behavioral measures reported here. Consistent with our previous electrophysiological results, the present results provide no evidence that noise exposure is related to significant perceptual deficits in young listeners with normal audiometric hearing. It is possible that the effects of noise-induced cochlear synaptopathy are only measurable in humans with extreme noise exposures, and that these effects always co-occur with a loss of audiometric sensitivity.

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“…“Translational Research in Audiology, Neurotology, and the Hearing Sciences”, with ten chapters discussing various aspects of translational research in the field [ 5 ].…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, “reverse translation” may be used to study observations made in the clinics during T2, using the “bedside-to-bench” approach ( Figure 1 ) [ 3 ]. TR is a rapidly progressing discipline first introduced in oncology and spreading to all other biomedical specialties [ 4 ], including audiology [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Translational Research in Audiology: Presence in the Literature

Szczepek

Domarecka

2022

Audiology Research

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Translational research is a process that focuses on advancing basic research-based clinical solutions and is characterized by a structured process accelerating the implementation of scientific discoveries in healthcare. Translational research originated in oncology but has spread to other disciplines in recent decades. A translational project may refer to pharmacological research, the development of non-pharmacological therapies, or to disease monitoring processes. Its stages are divided into basic research focused on the clinical problem (T0), testing the developed means in humans (T1), conducting trials with patients (T2), implementation and dissemination of successful approaches (T3), and improving community health (T4). Many audiological studies are translational in nature. Accordingly, this scoping review aimed to evaluate the use of the terms “translational audiology” and “translational research in audiology” in the literature and examine the goals of the identified studies. PubMed and Web of Science search identified only two publications meeting the search criteria. We conclude that identifying translational audiological studies in the literature may be hampered by the lack of use of the terms “translational audiology” or “translational research”. We suggest using these terms when describing translational work in audiology, with a view to facilitating the identification of this type of research and credit it appropriately.

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Perspectives on Auditory Translational Research

Cited by 4 publications

References 64 publications

Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

Effects of noise exposure on young adults with normal audiograms II: Behavioral measures

Translational Research in Audiology: Presence in the Literature

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