Perspectives in process analytics using low field NMR

Rudszuck, Thomas; Nirschl, Hermann; Guthausen, Gisela

doi:10.1016/j.jmr.2020.106897

Cited by 13 publications

(7 citation statements)

References 145 publications

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“…Very meaningful NMR data need to be acquired, possibly at high fields [ 52 ]; an increase in the magnetic field intensity results in higher spectra resolution and easier metabolite identification. A further promising application area could be also related to the very recent use of a low field NMR instrument, usually based on permanent magnets [ 53 , 54 , 55 ]. This latter takes advantage of both modern Fourier transform (FT)-based acquisition techniques as well as low operational costs [ 56 ].…”

Section: Nuclear Magnetic Resonance (Nmr)-based Studiesmentioning

confidence: 99%

Geographical Origin Assessment of Extra Virgin Olive Oil via NMR and MS Combined with Chemometrics as Analytical Approaches

Calò

Girelli

Wang

et al. 2022

Foods

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Geographical origin assessment of extra virgin olive oil (EVOO) is recognised worldwide as raising consumers’ awareness of product authenticity and the need to protect top-quality products. The need for geographical origin assessment is also related to mandatory legislation and/or the obligations of true labelling in some countries. Nevertheless, official methods for such specific authentication of EVOOs are still missing. Among the analytical techniques useful for certification of geographical origin, nuclear magnetic resonance (NMR) and mass spectroscopy (MS), combined with chemometrics, have been widely used. This review considers published works describing the use of these analytical methods, supported by statistical protocols such as multivariate analysis (MVA), for EVOO origin assessment. The research has shown that some specific countries, generally corresponding to the main worldwide producers, are more interested than others in origin assessment and certification. Some specific producers such as Italian EVOO producers may have been focused on this area because of consumers’ interest and/or intrinsic economical value, as testified also by the national concern on the topic. Both NMR- and MS-based approaches represent a mature field where a general validation method for EVOOs geographic origin assessment could be established as a reference recognised procedure.

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Section: Nuclear Magnetic Resonance (Nmr)-based Studiesmentioning

confidence: 99%

Geographical Origin Assessment of Extra Virgin Olive Oil via NMR and MS Combined with Chemometrics as Analytical Approaches

Calò

Girelli

Wang

et al. 2022

Foods

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“…The advent of benchtop NMR spectrometers has made NMR spectroscopy an even more attractive PAT tool. [9][10][11][12][13][14][15][16][17] Instead of using superconducting magnets that must be cooled by cryogenic media, benchtop NMR spectrometers are equipped with permanent magnets. The spectrometers are therefore compact, comparatively inexpensive to purchase and to maintain, and easy to operate.…”

Section: Introductionmentioning

confidence: 99%

Polarization transfer methods for quantitative analysis of flowing mixtures with benchtop ¹³C NMR spectroscopy

Phuong,

Romero,

Hasse

et al. 2023

Magnetic Reson in Chemistry

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Benchtop NMR spectroscopy is attractive for process monitoring; however, there are still drawbacks that often hamper its use, namely, the comparatively low spectral resolution in 1H NMR, as well as the low signal intensities and problems with the premagnetization of flowing samples in 13C NMR. We show here that all these problems can be overcome by using 1H‐13C polarization transfer methods. Two ternary test mixtures (one with overlapping peaks in the 1H NMR spectrum and one with well‐separated peaks, which was used as a reference) were studied with a 1 T benchtop NMR spectrometer using the polarization transfer sequence PENDANT (polarization enhancement that is nurtured during attached nucleus testing). The mixtures were analyzed quantitatively in stationary as well as in flow experiments by PENDANT enhanced 13C NMR experiments, and the results were compared with those from the gravimetric sample preparation and from standard 1H and 13C NMR spectroscopy. Furthermore, as a proxy for a process monitoring application, continuous dilution experiments were carried out, and the composition of the mixture was monitored in a flow setup by 13C NMR benchtop spectroscopy with PENDANT. The results demonstrate the high potential of polarization transfer methods for applications in quantitative process analysis with benchtop NMR instruments, in particular with flowing samples.

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“…Nuclear magnetic resonance (NMR) is one of the most powerful analytical methods that allows for the direct measurement of molecular information. Due to its non-invasive nature and the possibility of measuring the NMR signal contactless, NMR is widely used in biomedicine (Peng et al, 2014;Chen et al, 2021), chemistry (Singh and Blumich, 2018), agriculture (Colnago et al, 2021) and industrial applications (Rudszuck et al, 2021). Over the last ten to fifteen years, with technology advancements in the fields 20 of magnet design, pulse sequences and electronics, NMR has seen two major areas of evolution: In high-field NMR, the increasing requirements for sensitivity and resolution lead to sophisticated and cumbersome NMR devices based on superconducting magnets with higher and higher magnetic field strength and very high filed homogeneity (Gan et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

A CMOS-based NMR platform with arbitrary phase control and temperature compensation

Yang

Zhao

Dreyer

et al. 2022

Preprint

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Abstract. In this paper, we present a custom-designed nuclear magnetic resonance (NMR) platform based on a broadband complementary metal-oxide-semiconductor (CMOS) NMR-on-a-chip transceiver and a synchronous reference signal generator, which features arbitrary phase control of the TX pulse in combination with phase-coherent detection at a non-zero intermediate frequency (IF). Moreover, the presented direct digital synthesis (DDS) based frequency generator enables a digital temperature compensation scheme without the need for additional hardware. NMR spectroscopy and relaxometry measurements verify the functionality of the proposed frequency reference and temperature compensation scheme as well as the overall state-of-the-art performance of the presented system.

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Perspectives in process analytics using low field NMR

Cited by 13 publications

References 145 publications

Geographical Origin Assessment of Extra Virgin Olive Oil via NMR and MS Combined with Chemometrics as Analytical Approaches

Geographical Origin Assessment of Extra Virgin Olive Oil via NMR and MS Combined with Chemometrics as Analytical Approaches

Polarization transfer methods for quantitative analysis of flowing mixtures with benchtop ¹³C NMR spectroscopy

A CMOS-based NMR platform with arbitrary phase control and temperature compensation

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Perspectives in process analytics using low field NMR

Cited by 13 publications

References 145 publications

Geographical Origin Assessment of Extra Virgin Olive Oil via NMR and MS Combined with Chemometrics as Analytical Approaches

Geographical Origin Assessment of Extra Virgin Olive Oil via NMR and MS Combined with Chemometrics as Analytical Approaches

Polarization transfer methods for quantitative analysis of flowing mixtures with benchtop 13C NMR spectroscopy

A CMOS-based NMR platform with arbitrary phase control and temperature compensation

Contact Info

Product

Resources

About

Polarization transfer methods for quantitative analysis of flowing mixtures with benchtop ¹³C NMR spectroscopy