Perspectives for immune plasma treatment of COVID-19

Sayınalp, Başak; Çınar, Olgu Erkin; Haznedaroğlu, İbrahim C.

doi:10.3906/sag-2005-410

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…In another study, 103 patients with severe or life-threatening COVID-19 were randomly assigned to receive standard treatment with or without CP (114). Among the subset of patients who had severe but not life-threatening diseases, the rate of clinical improvement was more significant with immune plasma (115).…”

Section: Current Treatment Strategies Convalescent Immune Plasmamentioning

confidence: 99%

Clinical and Radiological Characteristics of Testicular Torsion Cases in Children and Adolescents and Postoperatively Follow-Up Results

BAYKARA

2023

esmj

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Introduction: Testicular torsion is a surgical acute condition characterised by loss of blood supply to the testicle due to abnormal bending of the testicle. Early diagnosis and treatment are vitally important for the prevention of testicular loss. In this study, we aimed to present the clinical and radiological features and postoperative follow-up results of testicular torsion cases in children and adolescents. Methods: In this cross-sectional study, the data of patients aged 17 years and younger who were operated for testicular torsion between January 2014 and June 2023 were evaluated retrospectively. Patients' age, symptoms, hospital admission time, physical examination findings, scrotal colour Doppler ultrasound results, surgical techniques (manual detorsion or orchiectomy) and late follow-up results were statistically analysed. Results: The mean age of 66 patients operated with the diagnosis of testicular torsion was calculated as 6.55 years (14 days-17 years). Left testicular torsion was detected in 48 (72.7%) and right testicular torsion in 18 (27.2%) patients. There were no cases of bilateral torsion. Four patients had a history of scrotal trauma and three patients had undescended testis. A history of sudden scrotal pain on awakening from sleep in the morning was reported by 31 patients (46.9%). When the time from the onset of symptoms to admission to the emergency department was evaluated, it was found that 50% (n=33) of the patients were admitted within 0-12 hours, 36.3% (n=24) within 12-24 hours and 13.6% (n=9) more than 24 hours. A total of 34 patients underwent orchiopexy and 32 patients underwent orchiectomy. Orchiectomy was performed in 15.1% of the patients with a presentation time of less than 12 hours, 79.1% of the patients with a presentation time of 12-24 hours and 88.9% of the patients with a presentation time of more than 24 hours. None of the patients with 360 degrees of torsion during surgery required orchiectomy. 64.5% of patients with 540 degrees of torsion and 92.3% of patients with 720 degrees of torsion underwent orchiectomy. Late orchiectomy was performed in 7 patients who developed testicular atrophy as a result of clinical follow-up. Conclusion: In children presenting with acute scrotum, it is vital that the differential diagnosis of testicular torsion is made and treated as soon as possible. However, raising public awareness for early presentation is as important as the surgical procedure

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Section: Current Treatment Strategies Convalescent Immune Plasmamentioning

confidence: 99%

Clinical and Radiological Characteristics of Testicular Torsion Cases in Children and Adolescents and Postoperatively Follow-Up Results

BAYKARA

2023

esmj

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“…6 The use of CP for treating COVID-19 is highly controversial. 7 Ye et al administered CP to six patients infected with SARS-CoV-2 and reported a rapid and dramatic improvement in patients who presented lung infiltration. 8 It was also reported that CP improved two patients with acute respiratory distress syndrome (ARDS) due to COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19

et al. 2022

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“…From the 10-14th day forward, the concentration decreases as a consequence of the immune response that justify the therapeutic use of convalescence plasma at an early stage of severe COVID-19 [4]. Positive serology can suggest an early, active, or late phase of the disease.…”

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confidence: 99%

Comparison of SARS-COV-2 antibody assays in PCR negative and PCR positive Turkish patients

Yağcı¹,

Sarınoğlu²,

Can³

et al. 2021

Turk J Med Sci

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To the editor, Serology may offer valuable information during COVID-19 pandemic however published papers mainly reported the results of symptomatic patients having positive RT-PCR on upper respiratory tract specimens [1]. More studies are needed to address whether asymptomatic patients, or patients with chest imaging compatible with COVID-19 but negative RT-PCR, have different antibody response that could influence assays performances. We wanted to share our data from Turkey where 4.323.596 COVID-19 cases were detected out of 44.087.628 PCR tests by April, 20, 2021 but there are only a couple of published studies about serodiagnosis of the infection.According to the interim guidance of WHO (Diagnostic testing for SARS-CoV-2), interpretations of serology should be made by an expert and are dependent on several factors including the timing of the disease, clinical morbidity, the epidemiology and prevalence within the setting, the type of test used, the validation method, and the reliability of the results . IDSA (Infectious Diseases of South America) guideline suggest not to use any serological test during the first 2 weeks following infection and to use IgG antibody to provide evidence of COVID-19 infection in symptomatic patients with a high clinical suspicion and repeatedly negative PCR results [2]. Commercially available serological assays for SARS-CoV-2 like ELISAs and lateral flow assays are high throughput, relatively inexpensive and use readily available instrumentation. These assays are performed with recombinant antigens, such as the spike protein (the main surface glycoprotein that is used to attach and enter cells) of SARS-CoV-2;

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Perspectives for immune plasma treatment of COVID-19

Cited by 5 publications

References 29 publications

Clinical and Radiological Characteristics of Testicular Torsion Cases in Children and Adolescents and Postoperatively Follow-Up Results

Clinical and Radiological Characteristics of Testicular Torsion Cases in Children and Adolescents and Postoperatively Follow-Up Results

Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19

Comparison of SARS-COV-2 antibody assays in PCR negative and PCR positive Turkish patients

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