Perspectives and Challenges of Using Chitosan in Various Biological Applications

Amirthalingam, Sivashanmugam; Rajendran, Arun; Prabaharan, M.; Rangasamy, Jayakumar

doi:10.1007/12_2021_107

Cited by 11 publications

(4 citation statements)

References 140 publications

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“…Chitosan, which is a polymer composed of N-acetyl-D-glucosamine units, resembling plant cellulose in structure, is the second most abundant carbohydrate found in the natural world. [ 19 ]. These units are considered to have prebiotic properties, as they provide essential nutrients that assist the growth of useful gut bacteria [ 20 ], which play a pivotal role in the well-being of the digestive and immune systems of monogastric farm animals, ensuring the integrity of the intestinal mucosa and maximizing metabolic energy efficiency [ 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Combined Dietary Supplementation of Tenebrio molitor Larvae and Chitosan in Growing Pigs: A Pilot Study

Zacharis,

Bonos,

Voidarou

et al. 2024

Veterinary Sciences

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Nowadays, the global animal industry faces considerable challenges in securing sufficient feed resources. Responding to consumer demands for reduced use of antibiotics in animal nutrition, better animal welfare status, and reduced impact on the environment, there is an increased urgency to develop innovative functional feeds with a reduced environmental footprint and the ability to improve meat quality and safety. In an effort to explore innovative feed ingredients for growing pig diets, the combined dietary supplementation of Tenebrio molitor larvae and chitosan was investigated. An experimental trial was performed with 48 weaned pigs (34 days of life; mixed sex) that were randomly assigned to four treatment groups (with six males and six females each): Group A (control), Group B (supplemented with T. molitor larvae at 10%), Group C (supplemented with chitosan at 0.05%), and Group D (supplemented with both ingredients at 10% and 0.05%, respectively). On the 42nd day of the experimental trial, samples of blood, feces, and carcass parts were taken for analysis. The results indicated that the insect larvae meal significantly improved (p < 0.05) overall performance, increased (p < 0.05) blood red blood cell content, increased meat phenolic content (p < 0.05), improved meat oxidative stability (p < 0.05), and affected meat fatty acid profile (p < 0.05). On the other hand, chitosan had no significant effect on overall performance (p > 0.05), but it significantly increased blood lymphocyte content (p < 0.05), affected the fecal microbiota (p < 0.05), improved meat oxidative stability (p < 0.05), increased meat phenolic content (p < 0.05), and affected meat fatty acid composition (p < 0.05) and (p < 0.05) meat color. Finally, the combined use of both T. molitor and chitosan significantly affected some important zootechnical parameters (p < 0.05), fecal microbial populations (p < 0.05), meat color (p < 0.05), and fatty acid profile (p < 0.05). Further investigation into the potential interaction between insect larvae meals and chitosan in pig diets is advised.

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Section: Introductionmentioning

confidence: 99%

Combined Dietary Supplementation of Tenebrio molitor Larvae and Chitosan in Growing Pigs: A Pilot Study

Zacharis,

Bonos,

Voidarou

et al. 2024

Veterinary Sciences

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“…Chitosan is a cationic polysaccharide biopolymer with wide biological applications owing to presence of reactive amino and hydroxyl groups in addition to its positive charge [9]. CS has superior physiochemical characteristics such as biodegradable, bioadhesive, and biocompatible [10]. It has great biomedical applications such as antifungal activity, wound healing potential, Anticancer, and Antidiabetic It was reported that CS enhances the delivery of INPs by forming a net-like non-toxic coating that holds several of INPs [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…CS has superior physiochemical characteristics such as biodegradable, bioadhesive, and biocompatible [10]. It has great biomedical applications such as antifungal activity, wound healing potential, Anticancer, and Antidiabetic It was reported that CS enhances the delivery of INPs by forming a net-like non-toxic coating that holds several of INPs [9][10][11][12]. The molecular weight of CS has a great in uence on the degree of interaction increasing the inhibition of certain enzymes [8].…”

Section: Introductionmentioning

confidence: 99%

Chitosan functionalized iron oxide nanocomposites as a novel carbonic anhydrase nano-inhibitor

Mostafa,

Fathy,

Khalil

et al. 2024

Inorganic Chemistry Communications

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“…As a medical aspect, biocompatibility, bioavailability, and biodegradability properties of new micro and nano-formulations to heal infected wounds should be considered as critical factors. In this regard, using of biomaterials is increasing due to these properties and also the reduction of hazardous compounds in the ecosystem (9,10). Biomaterials specifically primary and secondary metabolites of medicinal plants can also increase the therapeutic effect of other drugs (11,12).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and wound healing applications of curcumin in micro and nano-scaffolds based on chitosan, cellulose, and collagen

Alavi¹,

Zorab²,

Ashengroph³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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About 80% higher risk of amputation resulting from microbial infection was indicated for patients with diabetic foot ulcers (DFUs). Micro and nano-scaffolds made of natural polymers specifically cellulose, chitosan, and collagen can donate the biocompatibility, biodegradability, and bioavailability properties appropriate to accelerate wound closure before microbial biofilm formation. The antimicrobial activity of these wound dressings can be improved by the incorporation of bioactive compounds extracted from medicinal plant species such as curcumin. Low water solubility and poor bioavailability are recognized as two main disadvantages of curcumin, lipophilic phytopolyphenol, which could be controlled by targeted polymeric micro and nano-scaffolds. Consequently, this review has discussed the capacity and challenges of these types of formulations according to recent investigations.

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Perspectives and Challenges of Using Chitosan in Various Biological Applications

Cited by 11 publications

References 140 publications

Combined Dietary Supplementation of Tenebrio molitor Larvae and Chitosan in Growing Pigs: A Pilot Study

Combined Dietary Supplementation of Tenebrio molitor Larvae and Chitosan in Growing Pigs: A Pilot Study

Chitosan functionalized iron oxide nanocomposites as a novel carbonic anhydrase nano-inhibitor

Antibacterial and wound healing applications of curcumin in micro and nano-scaffolds based on chitosan, cellulose, and collagen

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