Ion channels, which are found in the membrane of all cells and several cellular organelles, can malfunction, causing a variety of different diseases known as channelopathies. One such example is ion channels, which are also crucial for controlling electrical activity and the signal transduction pathway that controls insulin. The route will signal for an increase in glucose transporters in the cell membrane if the hormone is required by muscle cells to support higher physical activity. As a result, this review investigates the channelopathy in diabetes mellitus.