Perspective: Don't be superficial

Boehncke, Wolf‐Henning

doi:10.1038/492s55a

Cited by 6 publications

(8 citation statements)

References 7 publications

(3 reference statements)

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“…[7][8][9] Systemic increase of such inflammatory markers in the peripheral blood reflects the recent trend that psoriasis is linked to other systemic diseases. 10 Our finding, showing elevated RDW values in psoriasis patients, accords with this recent trend because RDW is reported to be associated with inflammation in various systemic diseases.…”

Section: Discussionsupporting

confidence: 91%

“…Otherwise, high RDW may be associated with the fact that psoriasis patients accumulate cardiovascular risk factors such as diabetes and hypertension. 10 However, whether increased RDW in psoriasis patients is an independent risk for cardiovascular disorders or only a consequence of increased serum pro-inflammatory cytokines needs to be investigated in further studies. The precise reason of elevated RDW in previous reported diseases is unknown.…”

Section: Discussionmentioning

confidence: 99%

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Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients

Kim

Shin

Jee

et al. 2015

The Journal of Dermatology

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Circulating inflammatory cytokines and markers are increased in patients with psoriasis. Recent studies have shown that a higher red blood cell distribution width (RDW) is associated with disease activity in various disorders. Our objective was to investigate whether RDW is increased in psoriasis patients, and to evaluate its possible association with disease severity. We conducted a retrospective study of psoriasis patients seen in a university hospital in South Korea. Information about demographics, hematological parameters and disease severity were collected. Statistical analysis was performed using Student's t-test, multivariable logistic regression, Fisher's exact test and Spearman's rank correlation coefficient analysis as appropriate. A total of 261 psoriasis patients and 102 healthy controls were included in our study. The mean RDW value was significantly increased in psoriasis patients compared with healthy control (P = 0.037). Compared with mild psoriasis patients (Psoriasis Area and Severity Index [PASI], <7), moderate to severe patients (PASI, ≥7) showed significantly higher RDW values (P = 0.044). However, RDW did not show significant correlation with PASI (P = 0.358). When patients were divided into two groups according to their RDW value (<14.6% and ≥14.6%), the mean value of PASI was not significantly different (P = 0.219). Patients with psoriasis showed increased RDW values compared with healthy controls. It was also higher in the moderate and severe disease group than the mild group. Though this is only a pilot study, it is possible that RDW value can reflect the inflammatory status of psoriasis patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients

Kim

Shin

Jee

et al. 2015

The Journal of Dermatology

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“… 11 , 12 , 13 Although there are no clinically relevant biomarkers for psoriasis, increase of these indicators in peripheral circulation definitely reflects the recent trend that psoriasis is deeply associated with various systemic diseases. 14 In line with this concept, previous studies suggest that platelet activation is increased in patients with psoriasis. 15 , 16 Among the wide array of methods measuring platelet activation, MPV and PDW are most simple parameters to estimate platelet activity.…”

Section: Discussionmentioning

confidence: 74%

Mean Platelet Volume Is Elevated in Patients with Psoriasis Vulgaris

et al. 2015

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PurposeThis retrospective study was done to investigate the mean platelet volume (MPV) level in patients with psoriasis vulgaris and its relationship with disease severity.Materials and MethodsWe undertook a cross-sectional study on 176 patients and 101 healthy controls to examine the association between MPV and psoriasis. Various clinical and laboratory parameters were analyzed and compared.ResultsPlatelet distribution width and MPV were significantly higher in patients with psoriasis than controls. In addition, there was positive correlation between Psoriasis Area Severity Index (PASI) and MPV. When psoriasis patients were grouped into mild psoriasis (PASI<10) and moderate to severe psoriasis (PASI≥10), the MPV of the latter group was significantly elevated. Nevertheless, patients with higher MPV level (MPV≥10.4 fL) did not show higher PASI than lower MPV level (MPV<10.4 fL). MPV levels significantly decreased after improvements of psoriasis with various treatments. The variations of MPV and PASI also showed significant correlation.ConclusionWe have shown that MPV is increased in psoriasis patients and correlates with disease severity. Therefore, MPV levels may be considered as a marker of disease severity of psoriasis.

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“…Diseases of the skin can indicate an increased risk for separate co-morbid disorders. Two examples of this are palmoplantar keratoderma and psoriasis, both of which are associated with an increased risk for cardiovascular disease [16,17]. …”

Section: Introductionmentioning

confidence: 99%

Building a microphysiological skin model from induced pluripotent stem cells

et al. 2013

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The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs has created the opportunity to model diseases in culture systems, with the potential to rapidly advance the drug discovery field. Current methods of drug discovery are inefficient, with a high proportion of drug candidates failing during clinical trials due to low efficacy and/or high toxicity. Many drugs fail toxicity testing during clinical trials, since the cells on which they have been tested do not adequately model three-dimensional tissues or their interaction with other organs in the body. There is a need to develop microphysiological systems that reliably represent both an intact tissue and also the interaction of a particular tissue with other systems throughout the body. As the port of entry for many drugs is via topical delivery, the skin is the first line of exposure, and also one of the first organs to demonstrate a reaction after systemic drug delivery. In this review, we discuss our strategy to develop a microphysiological system using iPSCs that recapitulates human skin for analyzing the interactions of drugs with the skin.

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Perspective: Don't be superficial

Cited by 6 publications

References 7 publications

Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients

Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients

Mean Platelet Volume Is Elevated in Patients with Psoriasis Vulgaris

Building a microphysiological skin model from induced pluripotent stem cells

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