Perspective Chapter: Clinical Standard of a Geriatric Patient as a Virtual Target for Correction of Pharmacotherapy of Hypertension and Stroke in the Elderly

Abstract

One of the unresolved geriatric problems in neuropharmacology remains the lack of specifically designed drugs and therapeutic and preventive measures for older adults with hypertension and/or stroke. In particular, there are no standards for virtual geriatric patients aged 65–70 years, 70–90 years, and over 90 years, as well as courses of pharmacotherapy for diseases in them. The fact is that modern drugs and standards of their use in the treatment of diseases are still traditionally focused on a virtual object, which represents a person of mature age weighing about 70 kg. Therefore, it is proposed to develop clinical standards appropriate for three groups of geriatric patients. The main characteristics of health status, hypertension and rehabilitation of elderly people after a stroke, as well as the peculiarities of pharmacodynamics and pharmacokinetics of drugs are given. It is hoped that the use of such virtual targets will optimize the adjustment of treatment of hypertension and stroke in elderly people and will reduce drug complications and polypragmasy.

Idealization in pharmacology and pharmacy: Symbol of the chemical formula of one molecule of a substance and a real pharmaceutical product

“…Во-первых, описанный (предсказанный) механизм действия лекарств относится лишь к теоретическому миру, подразумеваемому в виде виртуального пациента среднего возраста, среднего пола, среднего состояния здоровья (живущего вечно, то есть «бессмертного»), имеющего массу тела около 70 кг, а лекарство проникает в его кровь таинственным образом в дозе, называемой «средней терапевтической дозой» [40].…”