Personalized therapy in obese patients with diabetes mellitus type 2 based on molecular-genetic data

Лапик, И.А.; Gapparova, K.M.; Chekhonina, Yu.G.; Алексеев, Д. В.

doi:10.20953/2224-5448-2019-2-19-25

Cited by 1 publication

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“…A glucose tolerance test showed a decreased level of insulin secretion in -866A allele carriers with T2D (Gomathi et al 2019), and insulin therapy was required for them more often and prescribed at earlier stages of the disease as compared with -866G allele carriers (D'Adamo et al 2004). The -866A allele was associated with T2D in women aged 40 to 65 years (OR = 2.18, P < 0.05) in a study by Russian authors (Lapik et al 2015). However, the opposite was demonstrated in several studies; e.g., the -866A allele was associated with reduced risk of T2D in the Italian population (Bulotta et al 2005) and a decreased insulin sensitivity was detected in the GG genotype carriers (P = 0.05) in the Danish population (Andersen et al 2013).…”

Section: G-866a Polymorphism Of the Ucp2 Genementioning

confidence: 90%

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

Pravednikova

Shevchenko

Kerchev

et al. 2020

Mol Med

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The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania. There is evidence that dysfunction of brown adipose tissue (BAT) may be a risk factor for obesity and type 2 diabetes (T2D). A significant number of studies in the field focus on the UCP family. The Ucp genes code for electron transport carriers. UCP1 (thermogenin) is the most abundant protein of the UCP superfamily and is expressed in BAT, contributing to its capability of generating heat. Single nucleotide polymorphisms (SNPs) of Ucp1–Ucp3 were recently associated with risk of cardiometabolic diseases. This review covers the main Ucp SNPs A–3826G, A–1766G, A–112C, Met229Leu, Ala64Thr (Ucp1), Ala55Val, G–866A (Ucp2), and C–55 T (Ucp3), which may be associated with the development of obesity, disturbance in lipid metabolism, T2D, and cardiovascular diseases.

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