Personalized nutrition diagnostics at the point-of-need

Lee, Seoho; Srinivasan, Balaji; Vemulapati, Sasank; Mehta, Saurabh; Erickson, David

doi:10.1039/c6lc00393a

Cited by 22 publications

(32 citation statements)

References 76 publications

(66 reference statements)

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“…Portable devices can also be used to determine food deficiency. For instance, ironPhone was coupled to point‐of‐care testing for assessment of iron status, an urgent public health problem related to maternal and child health . The device assessed the iron status based on serum ferritin levels.…”

Section: Applications In Field Research and Diagnosticsmentioning

confidence: 99%

Portable Multiplex Optical Assays

Coşkun

Topkaya

Yetisen

et al. 2018

Advanced Optical Materials

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performed at home and results can be integrated by online interfaces. [5] The test results and diagnostic information can be analyzed by the medical professionals from remote locations, improving the connectivity of central hubs to the public venues.Numerous scientific discoveries have been made in advanced settings and wellequipped laboratories. The necessity and complexity of these environments limit access to research equipment worldwide. Thus, decentralization of research laboratories has become an alternative solution to improve access to experimentation in field conditions. For instance, a paper origami microscope [6] that fit into a palm of a student made a powerful investigation tool for environment and materials. A detailed analysis of sound recordings by smartphones enabled identification of distinct mosquitoes. [7] These fielddeployable devices and platforms have stimulated emergence of citizen scientists, a population that collectively performs scientific inquiries in public settings.Rich biomolecular measurements from field-portable devices improve the quality of results in terms of accuracy and depth. Monitoring multiple blood markers has enabled diagnostic precision and thorough scientific investigation of blood constituent in patients. Therefore, field-deployable devices should ideally have multiplexed detection of target specimens. Design of such multiplexed detection technologies requires decent complexity at low cost for wide-scale adoptability.In this article, we provide an overview of field-compatible devices with high parameter analysis capabilities for both health monitoring purposes and scientifically enlightening Global health issues are increasingly becoming critical with high fatality rate due to chronic and infectious diseases. Emerging technologies aim to address these problems by understanding the causes of lethal conditions and diagnosing symptoms at early stage. Existing commercial diagnostics primarily focus on single-plex assays due to ease-of-use, simplicity in analysis, and amenability to mass manufacturing. Many research grade devices have utilized only a few molecular and morphological signatures in bodily fluids. However, multiplex devices can improve accuracy, sensitivity, and scalability of research and diagnostic devices. This review presents multiplex assays that utilize optical, electrical, and chemical methods and materials that have the potential to improve portable point-of-care diagnostics. The critical role of emerging optical and complementary assays with multiple contrast mechanisms is investigated to enable highly multiplex analysis in field settings. Multiparameter portable devices for field applications toward health monitoring, food testing, air quality monitoring, and microanalysis in other extreme conditions are examined. Current trends indicate the need for validation of health diagnosis based on a large number of biomarkers in randomized clinical trials. Advanced digital analysis, crowdsourced solutions, and robust user interfaces will become an integral ...

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Section: Applications In Field Research and Diagnosticsmentioning

confidence: 99%

Portable Multiplex Optical Assays

Coşkun

Topkaya

Yetisen

et al. 2018

Advanced Optical Materials

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“…In addition to that, it uses in-chip calibration by sample spiking with a known concentration of antigen. This low-cost and efficient innovation could provide accurate IDA diagnosis if integrated with the inflammation and infection analyte, C-reactive protein [ 31 ]. For signal processing to quantify the analyte, the device uses a laboratory size fluorescence microscope.…”

Section: State-of-the-art Microfluidic Devices For Iron Deficiencymentioning

confidence: 99%

Potential Point-of-Care Microfluidic Devices to Diagnose Iron Deficiency Anemia

Yap

Soair

Talik

et al. 2018

Sensors

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Over the past 20 years, rapid technological advancement in the field of microfluidics has produced a wide array of microfluidic point-of-care (POC) diagnostic devices for the healthcare industry. However, potential microfluidic applications in the field of nutrition, specifically to diagnose iron deficiency anemia (IDA) detection, remain scarce. Iron deficiency anemia is the most common form of anemia, which affects billions of people globally, especially the elderly, women, and children. This review comprehensively analyzes the current diagnosis technologies that address anemia-related IDA-POC microfluidic devices in the future. This review briefly highlights various microfluidics devices that have the potential to detect IDA and discusses some commercially available devices for blood plasma separation mechanisms. Reagent deposition and integration into microfluidic devices are also explored. Finally, we discuss the challenges of insights into potential portable microfluidic systems, especially for remote IDA detection.

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“…The use of paper microfluidics for POC diagnostics has been extensive and new assays continue to appear in the literature (Figure b–e) and on the market to aid global health epidemics like Ebola (Figure f) and Zika . Other POC diagnostics integrate traditional polymer‐based microfluidic devices with mobile technology with simple user interfaces, as shown in Figure g–k …”

Section: Examples Of Simple Solutions In Materials Science and Enginementioning

confidence: 99%

Simplicity as a Route to Impact in Materials Research

et al. 2017

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Materials scientists and engineers desire to have an impact. In this Progress Report we postulate a close correlation between impact - whether academic, technological, or scientific - and simple solutions, here defined as solutions that are inexpensive, reliable, predictable, highly performing, "stackable" (i.e., they can be combined and compounded with little increase in complexity), and "hackable" (i.e., they can be easily modified and optimized). In light of examples and our own experience, we propose how impact can be pursued systematically in materials research through a simplicity-driven approach to discovery-driven or problem-driven research.

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Personalized nutrition diagnostics at the point-of-need

Cited by 22 publications

References 76 publications

Portable Multiplex Optical Assays

Portable Multiplex Optical Assays

Potential Point-of-Care Microfluidic Devices to Diagnose Iron Deficiency Anemia

Simplicity as a Route to Impact in Materials Research

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