Personalized Management of Chronic Obstructive Pulmonary Disease via Transcriptomic Profiling of the Airway and Lung

Steiling, Katrina; Lenburg, Marc E.; Spira, Avrum

doi:10.1513/annalsats.201306-190aw

Cited by 6 publications

(5 citation statements)

References 49 publications

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“…While there are no specific studies of asthma or BPD, studies of healthy lung have also shown that the respiratory microbiome has complex biogeography (Dickson et al, 2015). Regional variability is also not unique to the airway microbiome, as it has been shown in other applications and other lung disease states such as the transcriptome in emphysema (Steiling et al, 2013). Thus, this geographic variability needs to be considered when comparing findings across research studies of lung diseases.…”

Section: Discussionmentioning

confidence: 95%

Microbial diversity within the airway microbiome in chronic pediatric lung diseases

Hahn

Warnken

Pérez‐Losada

et al. 2018

Infection, Genetics and Evolution

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The study of the airway microbiome in children is an area of emerging research, especially in relation to the role microbial diversity may play in acute and chronic inflammation. Three such pediatric airway diseases include cystic fibrosis, asthma, and chronic lung disease of prematurity. In cystic fibrosis, the presence of Pseudomonas spp. is associated with decreased microbial diversity. Decreasing microbial diversity is also associated with poor lung function. In asthma, early viral infections appear to drive changes in bacterial diversity which may be associated with asthma risk. Premature infants with Ureaplasma spp. are at higher risk for chronic lung disease due to inflammation. Microbiome changes due to prematurity also appear to affect the inflammatory response to viral infections post-natally. Importantly, microbial diversity can be measured using metataxonomic (e.g., 16S rRNA sequencing) and metagenomic (e.g., shotgun sequencing) approaches. A metagenomics approach may be preferable as it can provide further granularity of the sample composition, identifying the bacterial species or strain, information on additional microbial components, including fungal and viral components, information about functional genomics of the microbiome, and information about antimicrobial resistance mutations. Future studies of pediatric airway diseases incorporating these techniques may provide evidence for new treatment approaches for these vulnerable patient populations.

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Section: Discussionmentioning

confidence: 95%

Microbial diversity within the airway microbiome in chronic pediatric lung diseases

Hahn

Warnken

Pérez‐Losada

et al. 2018

Infection, Genetics and Evolution

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“…Using airway epithelial cells obtained by bronchoscopies from a large cohort of patients with and without COPD and segregated for pulmonary function test severity, signatures of gene expression have been identified by microarray in airway epithelia that are consistent with the gene expression data from lung tissues in patients with emphysema. 95 The expression of at least two oxidant-regulated genes are increased in COPD and include CYP2C 18, a P450 enzyme, and aryl hydrocarbon receptor nuclear translocator-like 2 ( ARNTL 2), a basic helix-loop-helix transcription factor that is active under conditions of low oxygen tension. 95 …”

Section: Genetic and Epigenetic Regulation Of Oxidative Stress In Copmentioning

confidence: 99%

“… 95 The expression of at least two oxidant-regulated genes are increased in COPD and include CYP2C 18, a P450 enzyme, and aryl hydrocarbon receptor nuclear translocator-like 2 ( ARNTL 2), a basic helix-loop-helix transcription factor that is active under conditions of low oxygen tension. 95 …”

Section: Genetic and Epigenetic Regulation Of Oxidative Stress In Copmentioning

confidence: 99%

COPD: balancing oxidants and antioxidants

Fischer

Voynow

Ghio

2015

COPD

166

145

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Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses in the world. The disease encompasses emphysema, chronic bronchitis, and small airway obstruction and can be caused by environmental exposures, primarily cigarette smoking. Since only a small subset of smokers develop COPD, it is believed that host factors interact with the environment to increase the propensity to develop disease. The major pathogenic factors causing disease include infection and inflammation, protease and antiprotease imbalance, and oxidative stress overwhelming antioxidant defenses. In this review, we will discuss the major environmental and host sources for oxidative stress; discuss how oxidative stress regulates chronic bronchitis; review the latest information on genetic predisposition to COPD, specifically focusing on oxidant/antioxidant imbalance; and review future antioxidant therapeutic options for COPD. The complexity of COPD will necessitate a multi-target therapeutic approach. It is likely that antioxidant supplementation and dietary antioxidants will have a place in these future combination therapies.

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“…Transcriptomic approaches to study the lung tissues in COPD will further improve the knowledge of molecular mechanisms underlying this heterogeneous disease and identify molecular subtypes of disease that have similar clinical manifestations (Steiling et al 2013 ).…”

Section: Gene Expression Studies Of Lung Tissue In Copdmentioning

confidence: 99%

Textbook of Personalized Medicine

Jain¹

2015

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Personalized Management of Chronic Obstructive Pulmonary Disease via Transcriptomic Profiling of the Airway and Lung

Cited by 6 publications

References 49 publications

Microbial diversity within the airway microbiome in chronic pediatric lung diseases

Microbial diversity within the airway microbiome in chronic pediatric lung diseases

COPD: balancing oxidants and antioxidants

Textbook of Personalized Medicine

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