Textbook of Personalized Medicine

Precision Medicine, Personalized Medicine, Omics and Big Data: Concepts and Relationships

“…In short, personalized medicine simply means selection of treatment best suited for an individual. Originally, personalized medicine is the concept that selection of a treatment should be tailored according to the individual patient's specific characteristics, including age, gender, height/weight, ethnicity, diet, and environment, versus a decision based on 'standards of care' derived by averaging responses across large cohorts of individuals in clinical trials [6].…”

“…All these launch a new era, the so-called genomic revolution era which offers us boundless potential and great promise including the development of personalized medical products for each individual based on his/her unique genomic information [7,8]. With the advance of genomics science and the emerging of new omics technologies, personalized medicine is now commonly defined as a combination of molecular profiling (omics methods) and traditional methods, such as family history, environment and lifestyle, to create diagnostic and therapeutic strategies precisely tailored to individual patients [5][6][7].…”

Assessment of temozolomide action encapsulated in chitosan and polymer nanostructures on glioblastoma cell lines

“…(PEGchitosan-clorotoxin-fluoroscopic agent nanoparticles may improve the resolution by 10 times) [9]. Nanovaccines are useful for immunotherapy, nanoantibiotherapy offers a lower risk of developing resistance to antibiotics and some nanostructures can be used in neuronal nanoprotection [10].…”

An Emerging Role of Biorepositories In Personalized Medicine: Isolation and Processing of Primary Tumor Cells For the Establishment of 3d Tumor Cultures From Solid Tumor Specimens

“…In contrast, the critical importance of technologies related to the derivation, short term culture, and testing of primary tumor cells from solid tumors is increasingly recognized (for a recent review see 2). Short-term primary cultures of tumor cells derived from pieces of solid tumors have been used for predicting anticancer drug responses [3,4]. Observations suggest that individualized drug sensitivity testing of solid tumors through the isolation and culturing primary tumor cells in 3D may soon become routine and modern tissue repositories will need to be ready to support these activities as they expand from their traditional research role to active participation in personalized medicine [5].…”