Personalized hydrogels for individual health care: preparation, features, and applications in tissue engineering

Kong, Fanting; Mehwish, Nabila; Niu, Xianjun; Lin, Mu; Rong, Xiaoying; Hu, Fang; Lee, Bae Hoon

doi:10.1016/j.mtchem.2021.100612

Cited by 11 publications

(12 citation statements)

References 173 publications

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“…Furthermore, including a porous structure in the hydrogel can significantly improve swelling behavior [ 21 ]. As a result, it is realistic to expect that hydrogels with a porous structure will have more applications in tissue engineering [ 37 , 38 , 39 ]. However, there have been scarcely any reports on the design and synthesis of bio-compatible, bio-degradable, and bio-mineralizable (3B) cost-effective transparent and opaque protein-based gels with highly improved mechanical properties and controlled pore structure.…”

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Mehwish

Lee

2022

Gels

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For porous protein scaffolds to be employed in tissue-engineered structures, the development of cost-effective, macroporous, and mechanically improved protein-based hydrogels, without compromising the original properties of native protein, is crucial. Here, we introduced a facile method of albumin methacryloyl transparent hydrogels and opaque cryogels with adjustable porosity and improved mechanical characteristics via controlling polymerization temperatures (room temperature and −80 °C). The structural, morphological, mechanical, and physical characteristics of both porous albumin methacryloyl biomaterials were investigated using FTIR, CD, SEM, XRD, compression tests, TGA, and swelling behavior. The biodegradation and biocompatibility of the various gels were also carefully examined. Albumin methacryloyl opaque cryogels outperformed their counterpart transparent hydrogels in terms of mechanical characteristics and interconnecting macropores. Both materials demonstrated high mineralization potential as well as good cell compatibility. The solvation and phase separation owing to ice crystal formation during polymerization are attributed to the transparency of hydrogels and opacity of cryogels, respectively, suggesting that two fully protein-based hydrogels could be used as visible detectors/sensors in medical devices or bone regeneration scaffolds in the future.

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Section: Introductionmentioning

confidence: 99%

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Mehwish

Lee

2022

Gels

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“…As the new generation of high-performance conductive elastomers, conductive hydrogel is widely used in sports monitoring, healthcare, electronic skins, energy storage devices, and other fields [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. However, due to the single and loose gel network of traditional synthetic hydrogels and the lack of efficient energy dissipation between the molecular chains, they often exhibit brittle and weak mechanical properties under external forces [ 8 , 9 ], which greatly limits their application development.…”

Section: Introductionmentioning

confidence: 99%

A Bilayer Skin-Inspired Hydrogel with Strong Bonding Interface

Yang

Cui

et al. 2022

Nanomaterials

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Conductive hydrogels are widely used in sports monitoring, healthcare, energy storage, and other fields, due to their excellent physical and chemical properties. However, synthesizing a hydrogel with synergistically good mechanical and electrical properties is still challenging. Current fabrication strategies are mainly focused on the polymerization of hydrogels with a single component, with less emphasis on combining and matching different conductive hydrogels. Inspired by the gradient modulus structures of the human skin, we propose a bilayer structure of conductive hydrogels, composed of a spray-coated poly(3,4-dihydrothieno-1,4-dioxin): poly(styrene sulfonate) (PEDOT:PSS) as the bonding interface, a relatively low modulus hydrogel on the top, and a relatively high modulus hydrogel on the bottom. The spray-coated PEDOT:PSS constructs an interlocking interface between the top and bottom hydrogels. Compared to the single layer counterparts, both the mechanical and electrical properties were significantly improved. The as-prepared hydrogel showed outstanding stretchability (1763.85 ± 161.66%), quite high toughness (9.27 ± 0.49 MJ/m3), good tensile strength (0.92 ± 0.08 MPa), and decent elastic modulus (69.16 ± 8.02 kPa). A stretchable strain sensor based on the proposed hydrogel shows good conductivity (1.76 S/m), high sensitivity (a maximum gauge factor of 18.14), and a wide response range (0–1869%). Benefitting from the modulus matching between the two layers of the hydrogels, the interfacial interlocking network, and the patch effect of the PEDOT:PSS, the strain sensor exhibits excellent interface robustness with stable performance (>12,500 cycles). These results indicate that the proposed bilayer conductive hydrogel is a promising material for stretchable electronics, soft robots, and next-generation wearables.

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“…Predictable success is now a reality for the rehabilitation of many challenging conditions as a consequence of ongoing research in treatment planning, implant designs, materials, and methodologies. A major challenge in the field of artificial tissue replacement and enhancement has always been the biocompatibility profiles of synthetic materials [ 5 ]. Moreover, these materials should mimic the appearance of a normal tooth (i.e., mineralized) and have characteristics of different dental sections [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Mussel-Inspired Surface Functionalization of Porous Albumin Cryogels Supporting Synergistic Antibacterial/Antioxidant Activity and Bone-Like Apatite Formation

Mehwish

Zaeem

et al. 2022

Gels

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A crucial method for adding new functions to current biomaterials for biomedical applications has been surface functionalization via molecular design. Mussel-inspired polydopamine (PDA) has generated much attention as a facile method for the functionalization of biomaterials because of its substantial independence in deposition, beneficial cell interactions, and significant responsiveness aimed at secondary functionalization. Because of their porous structure, the bovine serum albumin methacryloyl (BSAMA)-BM cryogels were functionalized with PDA (BM˗PDA), which may reproduce the architecture and biological purpose of the natural extracellular environment. Excellent antioxidative and antibacterial qualities, improved mineralization, and better cell responsiveness were all demonstrated by BM˗PDA. BM˗PDA scaffolds maintained their linked and uniform pores after functionalization, which can make it easier for nutrients to be transported during bone repair. As a result, hydroxyapatite (HA)-coated BM* and BM˗PDA* cryogels were created through successive mineralization with the goal of mineralized bone tissue repair. The heterogeneous nucleation and surface roughness contributed to rod-like apatite production in BM˗PDA* cryogels whereas BM* cryogels were made up of plate-like HA morphologies. Analysis results showed that after five cycles, the mineral contents were around 57% and the HA units remained equally dispersed on the surface of BM˗PDA* with a Ca/P ratio of 1.63. Other natural polymer-based cryogels can be coated using this general, rapid, and simple PDA coating technique and utilized as implants for bone tissue engineering. Future clinical uses of albumin cryogels for bone tissue engineering will advance as a result of additional in-vivo testing of such PDA-coated cryogels.

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Personalized hydrogels for individual health care: preparation, features, and applications in tissue engineering

Cited by 11 publications

References 173 publications

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

A Bilayer Skin-Inspired Hydrogel with Strong Bonding Interface

Mussel-Inspired Surface Functionalization of Porous Albumin Cryogels Supporting Synergistic Antibacterial/Antioxidant Activity and Bone-Like Apatite Formation

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