Mussel-Inspired Surface Functionalization of Porous Albumin Cryogels Supporting Synergistic Antibacterial/Antioxidant Activity and Bone-Like Apatite Formation

Abstract

A crucial method for adding new functions to current biomaterials for biomedical applications has been surface functionalization via molecular design. Mussel-inspired polydopamine (PDA) has generated much attention as a facile method for the functionalization of biomaterials because of its substantial independence in deposition, beneficial cell interactions, and significant responsiveness aimed at secondary functionalization. Because of their porous structure, the bovine serum albumin methacryloyl (BSAMA)-BM cryogels were functionalized with PDA (BM˗PDA), which may reproduce the architecture and biological purpose of the natural extracellular environment. Excellent antioxidative and antibacterial qualities, improved mineralization, and better cell responsiveness were all demonstrated by BM˗PDA. BM˗PDA scaffolds maintained their linked and uniform pores after functionalization, which can make it easier for nutrients to be transported during bone repair. As a result, hydroxyapatite (HA)-coated BM* and BM˗PDA* cryogels were created through successive mineralization with the goal of mineralized bone tissue repair. The heterogeneous nucleation and surface roughness contributed to rod-like apatite production in BM˗PDA* cryogels whereas BM* cryogels were made up of plate-like HA morphologies. Analysis results showed that after five cycles, the mineral contents were around 57% and the HA units remained equally dispersed on the surface of BM˗PDA* with a Ca/P ratio of 1.63. Other natural polymer-based cryogels can be coated using this general, rapid, and simple PDA coating technique and utilized as implants for bone tissue engineering. Future clinical uses of albumin cryogels for bone tissue engineering will advance as a result of additional in-vivo testing of such PDA-coated cryogels.

MWCNTs-TiO2 Incorporated-Mg Composites to Improve the Mechanical, Corrosion and Biological Characteristics for Use in Biomedical Fields

“…As a result, the well-dispersed surface with identifiable active particles and fillers leads to the inhibition of bacteria. Taken together, the addition of various amounts of fillers, such as TiO 2 and CNTs, into the composites has a significant influence on the biological response, corrosion behavior and mechanical properties of the Mg-based composite [66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83].…”

A Novel Bio-Adhesive Based on Chitosan-Polydopamine-Xanthan Gum for Glass, Cardboard and Textile Commodities

“…The spectra of polydopamine synthesized extrinsically (C) and added to chitosan, and intrinsically (D) (polydopamine-chitosan), are characterized by similar absorption bands. The -OH and -NH stretching was observed at 3272 cm −1 , the asymmetric and symmetric stretching of -CH was represented by a band around 2900 cm −1 , the -C=O stretching of amide I was observed at 1645 cm −1 [34,35]. The water resistance property of chitosan-based adhesive formulations was tested by soaking glass samples in water.…”

Enhancing Icephobic Coatings: Exploring the Potential of Dopamine-Modified Epoxy Resin Inspired by Mussel Catechol Groups

“…The spectra reveal distinct features for each compound. In the case of dopamine hydrochloride, the bands at 3333 cm −1 and 3206 cm −1 correspond to the stretching vibrations of the primary amine group, while the band at 1604 cm −1 can be attributed to its bending vibrations [ 37 , 38 ]. For the other compound, pristine epoxy resin, the stretching vibration band of the oxirane group can be seen at 906 cm −1 [ 39 ].…”