Personalized charts for the fetal corpus callosum length

Tsur, Abraham; Weisz, Boaz; Rosenblat, Orgad; Shai, Daniel; Derazne, Estela; Stevenson, David K.; Achiron, Reuven; Katorza, E.

doi:10.1080/14767058.2018.1479389

Cited by 13 publications

(26 citation statements)

References 18 publications

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“…They showed that using the ratio significantly increased the percentage of measurements defined as normal among otherwise normal fetuses, but not among fetuses with other suspected brain anomalies. One of the limitations of the trial was the lack of long‐term neurodevelopmental follow‐up …”

Section: Discussionmentioning

confidence: 99%

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Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum

et al. 2019

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Objective Data regarding the neurodevelopmental outcome of fetal short corpus callosum (CC) diagnosed according to standard reference charts is scarce. The purpose of this study was to assess whether the finding is related to neurodevelopmental delay, and to examine reclassification to normal fetal CC length using CC length/EFW ratio. Method Historical prospective cohort study including pregnant women who were referred for fetal neurosonogram due to abnormal CC. Short CC was defined below the 5th percentile according to reference charts. Twenty cases were included in the study group and compared with a control group of 59 normal cases. The patients in the study group were divided into two groups according to CC length/EFW ratio. Children's neurodevelopment was assessed using the Vineland Adaptive Behavior Scale (VABS). Results VABS scores were within normal range in 90% of the cases. There was no significant statistical difference between the study group and the control group. In addition, there was no statistically significant difference between fetuses reclassified as normal callosal length according to CC length/EFW ratio in comparison to the control group. Conclusion The neurodevelopmental outcome of fetuses with diagnosed short CC did not differ from the neurodevelopment of normal fetuses in the control group.

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Section: Discussionmentioning

confidence: 99%

“…CC was regarded as short if it was measured below the 5 th percentile according to the reference charts in the normograms according to Achiron and Cignini . Due to possible population, sex and growth percentile differences related to callosal length, we also used CC length/EFW ratio to improve the diagnostic accuracy …”

Section: Methodsmentioning

confidence: 99%

Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum

et al. 2019

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“…Previous studies showed that certain factors may have an impact on the CC including ethnicity, fetal growth percentiles, and gender, which was shown to affect CC thickness . However, some studies did not find that gender had a clinically meaningful effect on its size or morphology .…”

Section: Discussionmentioning

confidence: 99%

“…Many previous studies suggested various diagnostic tools in an attempt to confront this problem . There are several reference charts for assessing CC biometrics according to gestational age . Tsur et al showed that the ratio between the CC length and estimated fetal weight had a strong linear correlation and suggested adjusting CC length to fetal growth parameters.…”

Section: Discussionmentioning

confidence: 99%

“…While the diagnosis of complete agenesis is straightforward, assessment of a short corpus callosum (SCC) is more challenging and requires the use of reference charts for normal dimensions, based on gestational age . This study aimed to establish a method for rapid detection of a SCC based on measurement of the ratio between the internal cranial occipitofrontal dimension (ICOFD) in midsagittal plane and the CC length.…”

Section: Introductionmentioning

confidence: 99%

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A new method for evaluating short fetal corpus callosum

et al. 2019

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Objective Sonographic diagnosis of short corpus callosum (SCC) is based on measurement of a short for gestational age antero‐posterior length of the corpus callosum (CC) in the midsagittal plane. We suggest a new method for evaluating SCC without referring to biometry tables. Methods We measured the ratio between the CC length and the internal cranial occipitofrontal dimension (ICOFD) in the midsagittal plane in 399 normal fetuses at 20 + 6 to 35 + 3 weeks of gestation and in 31 fetuses with a diagnosis of a SCC and compared the mean ratio between two groups. The impact of cephalic biometric parameters, fetal presentation, and gender was assessed. Results The ICOFD/CC length for normal pregnancies was constant throughout the pregnancy (2.35 ± 0.11). There was no correlation between the ICOFD/CC length and cephalic index, Biparietal Diameter (BPD), head circumference, fetal sex, or fetal presentation. The ratio of pregnancies with SCC was significantly higher: 3.20 ± 0.84 (P < .0001). Conclusion The ICOFD/CC length practically does not change throughout a normal pregnancy. The ratio was significantly higher in pregnancies with SCC. Measuring this ratio during fetal anatomical scan may enable rapid evaluation of the CC without the need to refer to biometry tables.

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Prenatal diagnosis of a likely pathogenic variant in ZBTB18: Natural evolution of fetal phenotype including the long bones and corpus callosum

Birnbaum

Markovitch

Biron‐Shental

et al. 2021

American J of Med Genetics Pt A

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Pathogenic variants in ZBTB18 gene have been described only postnatally with a variable phenotypic spectrum that includes intellectual disability, microcephaly, hypotonia, poor growth, corpus callosum abnormalities, seizures, and dysmorphic facial features. These features overlap with the phenotype of 1q43-q44 deletion syndrome (OMIM #612337). There are several genes within the 1q43-q44 deletion region, and ZBTB18 is of particular interest due to its known involvement in neuronal differentiation and migration. We describe here a fetus presenting with an intrauterine growth restriction, diminished long bones growth, single umbilical artery, and a short corpus callosum. On mid pregnancy ultrasound, all biometric parameters including the corpus callosum were relatively small but still within the normal range. Only a targeted follow-up during the third trimester, including neurosonographic and MRI exams, revealed the full extent of the malformation, leading to amniocentesis and a genetic workup that led to the identification of a de novo likely pathogenic variant in ZBTB18 gene. This is the first description of the evolving phenotype of a ZBTB18-related disorder in a fetus, which emphasizes the challenging diagnosis of subtle findings, that mandates a high level of clinical suspicion and a targeted follow-up throughout pregnancy.

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Personalized charts for the fetal corpus callosum length

Cited by 13 publications

References 18 publications

Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum

Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum

A new method for evaluating short fetal corpus callosum

Prenatal diagnosis of a likely pathogenic variant in ZBTB18: Natural evolution of fetal phenotype including the long bones and corpus callosum

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