Personalized Cancer Care: Risk Prediction, Early Diagnosis, Progression, and Therapy

Abstract

At the annual prestigious International Symposium of the Fritz-Bender Foundation, Munich, 18-20 May, 2016, researchers, clinicians, and students discussed the state of the art and future perspectives of genomic medicine in cancer. Genomic medicine (also known as precision medicine/oncology) should help clinicians to provide a more precise diagnosis and therapy in oncology for individual patients. The meeting focused on next-generation sequencing methods, analytical computational analysis of big data, and data mining on the way to translational and evidence-based medicine. The meeting covered the social and ethical impact of genomic medicine as well as news and views on antibody targeting of intracellular proteins, on the architecture of intracellular proteins and their impact on carcinogenesis, and on the adaptation of tumor therapy in due consideration of tumor evolution. Subheadings like "Genetic Profiling of Patients and Risk Prediction," "Molecular Profiling of Tumors and Metastases," "Tumor-Host Microenvironment Interaction and Metabolism," and "Targeted Therapy" were subsumed under the main heading of "Personalized Cancer Care." What Is It about?This meeting report is a follow-up progress report from a previous one in 2013. It summarizes at the cutting edge how cancer manifests in the human body. Basic scientists and clinicians shared their views on personal cancer care and precision cancer medicine with special reference to epigenetic, genetic, and novel therapy strategies.

The importance of precision medicine in modern molecular oncology

“…The worldwide importance of precision medicine/oncology was stressed by US President Obama when he announced the Precision Medicine Initiative® in his State of the Union address on January 20, 2015 90 . Precision medicine is a concept of individualized gene therapy using genomics, transcriptomics, and proteomics analyses to achieve personalized and accurate diagnosis and treatment of the diseases.…”

“…Cancer immunotherapy is undergoing rapid advances, changing the pattern of survival with immunotherapy. Exosomes are favored for the study as promising agents for immunotherapy of cancer in recent years.7 | CONCLUSIONSThe worldwide importance of precision medicine/oncology was stressed by US President Obama when he announced the Precision Medicine Initiative ® in his State of the Union address on January 20, 2015 90. Precision medicine is a concept of individualized gene therapy using genomics, transcriptomics, and proteomics analyses to achieve personalized and accurate diagnosis and treatment of thediseases.…”