The importance of precision medicine in modern molecular oncology

Abstract

With the rapid development of modern medical technology, information data modeling has been gradually applied to clinical diagnosis and treatment. Precision medicine is an important approach that focuses on individual patients in terms of their own characteristics, genomic information, proteomics and even social environments. Genome‐wide high‐throughput technologies, including DNA‐seq, RNA‐seq, exosome‐seq…, contribute enormous amounts of molecular data to aid in diagnosis and analysis. Here, we review the developmental history of different next‐generation sequencing platforms, introduce their applications in different tumor diagnosis and therapy, and further discuss the remaining challenges in precision medicine.

Understanding communication between patients and healthcare professionals regarding comprehensive biomarker testing in precision oncology: A scoping review

“…In the last decade, fast‐evolving medical technologies, such as the expansion of high‐throughput next‐generation sequencing, have increased the availability of cBT and thus hope for improved cancer treatment 6,7 . The inherent paradigm shift to histology‐agnostic, biomarker‐directed treatment has profoundly changed the interplay of research and clinical practice and the collaboration of different professions within the medical field 8,9 …”

“…4,5 In the last decade, fast-evolving medical technologies, such as the expansion of high-throughput next-generation sequencing, have increased the availability of cBT and thus hope for improved cancer treatment. 6,7 The inherent paradigm shift to histology-agnostic, biomarker-directed treatment has profoundly changed the interplay of research and clinical practice and the collaboration of different professions within the medical field. 8,9 This paradigm shift has influenced patient management, whereby standard practices for evidence generation (e.g., registration trials and integration of real-world studies) blur the lines between research and clinical practice.…”

Intimidad de la información genética predictiva en oncología

“…El diagnóstico germinal es aquel que se realiza en células o tejidos naturales de la persona, permitiendo conocer la constitución genética que tiene desde su concepción y, por lo tanto, el resultado de la unión y mezcla de los cromosomas del padre y madre biológicos, lo que implica inherentemente tener una inspección de la condición genética de una familia. Por otra parte, el diagnóstico somático es el que se realiza en el tumor que está o estuvo alojado en la persona, describiendo principalmente las alteraciones genéticas que adquirió este tejido anómalo, pero pudiendo a su vez representar la condición genética propia del individuo ya que a fin de cuentas el tumor se desarrolló de una de las células naturales del individuo (Wang y Zheng, 2021).…”

Metagenomic next-generation sequencing contributes to the diagnosis of mixed pulmonary infection: a case report

“…No abnormality was found in bronchoscopy, and BALF samples were collected for microbial culture, G and GM test, M. tuberculosis DNA test, and fungal and Cryptococcus smear, all of which proved negative. In the meantime, a BALF specimen was directly sent to Clinical Genome Center, Guangxi Kingmed Diagnostics, for mNGS in accordance with the previous references [ 11 , 12 ]. On the 9th day, the mNGS result (see Additional file 1 for the methods of mNGS) reported a total of 66521 single-end reads in the pathogen genomic DNA, of which 537 reads were Corynebacterium striatum , with a coverage of 1.37% (Fig.…”