Personality pathways to mortality: Interleukin-6 links conscientiousness to mortality risk

Ó’Súilleabháin, Páraic S; Turiano, Nicholas A.; Gerstorf, Denis; Luchetti, Martina; Gallagher, Stephen; Sesker, Amanda A.; Terracciano, Antonio; Sutin, Angelina R.

doi:10.1016/j.bbi.2021.01.032

Cited by 28 publications

(54 citation statements)

References 55 publications

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“…Largely consistent with past research (e.g., O'Súilleabháin et al, 2021;Sutin et al, 2010), conscientiousness and neuroticism were the traits showing associations with the biomarkers. Overall, both self-and informant-report traits had similar associations with inflammatory markers.…”

Section: Discussionsupporting

confidence: 89%

“…Second, it is unclear whether personality traits' associations with three physical health indices are mediated by IL-6, CRP, and TNF-a, as this path has not been examined. Recent work by O'Súilleabháin et al (2021) tested if inflammation mediated the pathway between personality and mortality and primarily found associations for conscientiousness and IL-6. We seek to extend these results by examining a third biomarker (TNF-a) and three indicators of physical health.…”

Section: Current Studymentioning

confidence: 99%

See 1 more Smart Citation

Prospective self- and informant-personality associations with inflammation, health behaviors, and health indicators.

Wright¹,

Weston²,

Norton³

et al. 2022

Health Psychology

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Objective: Personality influences many aspects of the health process. It is unclear to what extent selfand informant-reports of the Big Five offer incremental validity for the prediction of inflammatory biomarkers and whether inflammation provides a unique pathway between personality and indicators of physical health, independent of health behaviors. Method: Using data from older adults (N = 1,630) enrolled in the St. Louis Personality and Aging Network study, we tested whether self-and informant-reported Big Five traits show unique associations with inflammation (IL-6, CRP, TNF-a). Further, we tested whether inflammation and health behaviors indirectly link personality to healthrelated quality of life, body mass index, and chronic disease burden using longitudinal mediation in a structural equation modeling framework. Results: Self-reports, informant-reports, and general trait factors of personality predicted future inflammatory biomarker levels (unstandardized regression coefficients ranged À.08 to .07 for self, À.13 to À.10 for informants, and À.16 to À.11 for general). Additionally, all assessment methods of personality were associated with the indicators of physical health through biomarker and health behavior pathways. Effects were primarily found for conscientiousness and neuroticism; IL-6 and CRP were the biomarkers with the most indirect effects; and indirect paths overall emerged more frequently through health behaviors, but this varied by outcome. Conclusions: Self-and informant-reports provided unique predictive validity of inflammatory biomarkers. Findings highlight the benefits of using of multiple assessments of personality and the importance of examining multiple, distinct pathways by which personality might influence health to understand the mechanisms underlying this relationship more fully.

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Section: Discussionsupporting

confidence: 89%

Section: Current Studymentioning

confidence: 99%

Prospective self- and informant-personality associations with inflammation, health behaviors, and health indicators.

Wright¹,

Weston²,

Norton³

et al. 2022

Health Psychology

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“…The impact of psychological factors on the incidence of CRC has been studied including anxiety and depression (Kroenke et al, 2005) and perceived stress (Kikuchi et al, 2017). Such studies are coherent with paradigms that consider psychological components and personality characteristics as factors affecting mortality (Roberts et al, 2007;O'Súilleabháin et al, 2021). According to recent works, psychological traits seem to share a common pathogenic mechanism typical of increased mucosal inflammation, metabolic parameters and proinflammatory status (Mancini et al, 2020).…”

Section: Introductionmentioning

confidence: 96%

“…In particular, behavioral and life-style patterns as dietary habits, physical inactivity, obesity and abdominal fat, smoking and alcohol consumption have been associated with the incidence of diseases such as CRC (Murphy et al, 2019 ). Such personality and behavioral factors may influence cancer development and progression through mechanisms such as cellular immune response, oxidative stress, invasion, angiogenesis and inflammation (Jaffe, 2013 ; Di Giuseppe et al, 2018 ; O'Súilleabháin et al, 2021 ). However, studies investigating premorbid common traits in individuals developing any type of cancer showed controversial results: some large-scale cohort studies found no association between personality and cancer incidence (Temoshok, 1987 ; Jokela et al, 2014 ), while other studies did (Lemogne et al, 2013 ; Dong and Jin, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Personality Factors in Colorectal Cancer: A Systematic Review

et al. 2021

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Background: The role of personality in cancer incidence and development has been studied for a long time. As colorectal cancer (CRC) is one of the most prevalent cancer types and linked with lifestyle habits, it is important to better understand its psychological correlates, in order to design a more specific prevention and intervention plan. The aim of this systematic review is to analyze all the studies investigating the role of personality in CRC incidence.Methods: All studies on CRC and personality up to November 2020 were scrutinized according to the Cochrane Collaboration and the PRISMA statements. Selected studies were additionally evaluated for the Risk of Bias according to the Newcastle-Ottawa Scale (NOS).Results: Eight studies met the inclusion criteria and were eventually included in this review. Two main constructs have been identified as potential contributors of CRC incidence: emotional regulation (anger) and relational style (egoism).Conclusion: Strong conclusions regarding the influence of personality traits on the incidence of CRC are not possible, because of the small number and the heterogeneity of the selected studies. Further research is needed to understand the complexity of personality and its role in the incidence of CRC and the interaction with other valuable risk factors.

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“…Also, the authors highlighted the importance of biological pathways that linked personality to future mortality risk. A recent study found that higher conscientiousness was associated with lower risk of mortality (O'Súilleabh ain et al, 2021).…”

Section: Introductionmentioning

confidence: 98%

Coping with stress and personality: A study in pregnancies complicated by hypertension

Chapuis-de-Andrade

Moret-Tatay

Irigaray

et al. 2021

Clin Psychology and Psychoth

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Objective: The objective of this work is to investigate the role of personality in pregnancies complicated by hypertension, thru analysis of structure and associations between negative affect and coping strategies, and their role towards psychological distress.Method: A cross-sectional study with 343 women, where 192 pregnancies complicated by hypertension, was carried out by employing the following tools: the five-factor model (Big Five), Depression, Anxiety and Stress Scale (DASS-21), and Jalowiec's Coping Inventory. Two complementary strategies were carried out: an exploratory approach on the interactions between latent variables and a confirmatory technique. Results:Coping strategies seem to be dissociated in the hypertensive group, and these participants tend to use strategies according to their personality, mostly emotion focused, extraversion, and neuroticism. The extraversion model exclusively shows an acceptable goodness-of-fit after a structural equation modelling. A multigroup analysis reached a full metric invariance level for extraversion.Conclusions: These results are of interest for both clinical and research settings.Prenatal screening and associated interventions may reduce perinatal negative affective states and related pregnancy complications.

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Personality pathways to mortality: Interleukin-6 links conscientiousness to mortality risk

Cited by 28 publications

References 55 publications

Prospective self- and informant-personality associations with inflammation, health behaviors, and health indicators.

Prospective self- and informant-personality associations with inflammation, health behaviors, and health indicators.

Personality Factors in Colorectal Cancer: A Systematic Review

Coping with stress and personality: A study in pregnancies complicated by hypertension

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