Personality and personality disorders predict development and relapses of major depression

Abstract

The aim of this study was to investigate the role of personality deviations in the development and relapses of major depression. The study is based on an investigation of an initial sample of 298 psychiatric out-patients, who were re-evaluated after 6 years when the sample included 253 patients. SCID-R was used for assessment of possible relapses and new cases, and a logistic regression analysis was used to determine the best prediction of the recurrence of depression. Borderline personality disorders and dependency predicted relapses. In addition, borderline personality disorders, together with avoidant personality disorders, predicted the development of new cases. Comorbid clinical syndromes appear to be of no importance. These findings suggest that the comorbidity with personality deviations accounts for the chronicity and poor prognosis in major depression.

Basal microRNA expression patterns in reward circuitry of selectively bred high-responder and low-responder rats vary by brain region and genotype

“…Conversely, differential expression in a single brain region was validated for miR-26b, miR-128a, miR-194, and miR-340-5p (in PL, Fig. 5A), as well as miR-29b and 1 The online version of this article contains supplemental material. Table S6.…”

“…Past studies have highlighted the important observation that personality traits can be strong predictors of certain psychopathologies (1,23,25). In humans, for example, the behavioral measure of novelty-seeking is directly correlated with the development of externalizing disorders (e.g., drug abuse) and inversely correlated with the development of internalizing disorders (e.g., anxiety and depression) (10).…”

Two-Year Prospective Naturalistic Study of Remission From Major Depressive Disorder as a Function of Personality Disorder Comorbidity.

“…Many studies, but not all, have suggested that PDs may have a negative impact on the course or outcome of Axis I disorders Grilo, McGlashan, & Oldham, 1998). For instance, some research has found that PDs predict development of depression (Alnaes & Torgersen, 1997), poorer response to treatment for depression (Mulder, 2002), and relapse to depression (Hart, Craighead, & Craighead, 2001;Ilardi, Craighead, & Evans, 1997).…”

Validation of two informant-based screening instruments for personality disorders in a psychiatric outpatient population

“…Early recognition of these frequently occurring PDs is extremely important, because they cause serious psychosocial problems and can hinder the course and the treatment of psychiatric disorders [3][4][5] . Since comorbid PDs can adversely affect the management of mental illnesses, assessment of the personality status of patients should be an essential part of every psychiatric examination [6,7] .…”