1988
DOI: 10.1001/archderm.124.2.244
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Persistent subepidermal blistering in split-thickness skin graft sites. Ultrastructural and antigenic features simulating dystrophic or immunofluorescence-negative acquired epidermolysis bullosa

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Cited by 9 publications
(6 citation statements)
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“…An anchoring fibril defect has been proposed as the underlying cause of delayed postburn blisters (1,4). The staining for collagen VII in our study showed a discontinuous pattern in the blister roof, but this pattern was seen with the stains for the other basement membrane components as well and was consistent with the discontinuous structure of the basement membrane as observed by electron microscopy.…”
Section: Discussionsupporting
confidence: 86%
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“…An anchoring fibril defect has been proposed as the underlying cause of delayed postburn blisters (1,4). The staining for collagen VII in our study showed a discontinuous pattern in the blister roof, but this pattern was seen with the stains for the other basement membrane components as well and was consistent with the discontinuous structure of the basement membrane as observed by electron microscopy.…”
Section: Discussionsupporting
confidence: 86%
“…. , was performed, the blisters have been found to be subepidermal (2)(3)(4). Therefore, it has been assumed that the problem lies in the basement membrane zone and/or the superficial subepidermal connective tissue (1).…”
mentioning
confidence: 99%
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“…Its pathogenic process is similar to that of human epidermolysis bullosa [17,19,31]. In the case of grafted human skin, further more, insufficient formation of BMZ proteins including type IV collagen, type VII collagen and laminin 5 cause detachment of the epidermis from the dermis [7,10]. Though such deterioration can be observed within the dermo-epidermal junction in early phase of acute laminitis, dissection of the chronically affected hoof shows existence of the hypertrophic LE between the ectopic white line tissue (lamellar wedge) and the distal phalanx [16,18,29].…”
mentioning
confidence: 97%
“…23 BSSs are commercially available, are easy to apply, and eliminate the need for donor-site harvesting. Although skin substitutes have been used to facilitate healing of chronic wounds in EB patients, 5,7,[24][25][26] their role in postsurgical defects in this population needs to be further investigated.…”
Section: Closure Optionsmentioning
confidence: 99%