Mohs Micrographic Surgery for Squamous Cell Carcinoma Associated with Epidermolysis Bullosa

Saxena, Aradhna; Lee, Jason B.; Humphreys, Tatyana R.

doi:10.1111/1524-4725.2006.32021

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…A number of different techniques of minimally invasive surgery have been used in EB SCCs, including Mohs micrographic surgery, rush paraffin sections (‘slow Mohs’) and chemosurgery …”

Section: Surgical Treatmentmentioning

confidence: 99%

“…Different approaches to wound closure following excision of EB SCCs have been employed, including healing by secondary intention, autologous split skin, epidermal or full‐thickness grafting, allogeneic skin grafting, cadaveric skin grafting, artificial skin equivalents, flaps, application of autologous or allogeneic keratinocyte suspensions, or combinations of the above . Of these techniques, split‐skin grafting has been most frequently employed, usually with meshing, although donor sites in EB may be complicated by delayed healing.…”

Section: Surgical Treatmentmentioning

confidence: 99%

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Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa: best clinical practice guidelines

et al. 2015

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SummaryThis article summarizes recommendations reached following a systematic literature review and expert consensus on the diagnosis and management of cutaneous squamous cell carcinomas in people with epidermolysis bullosa. The guidelines are intended to help inform decision making by clinicians dealing with this complex complication of a devastating disease.What's already known about this topic?• Some subtypes of epidermolysis bullosa (EB), particularly severe generalized recessive dystrophic EB, are associated with the development of mucocutaneous squamous cell carcinomas (SCCs).• These tumours behave aggressively and are a leading cause of morbidity and mortality in at-risk patients with EB.What does this study add?• These guidelines will assist clinicians in the diagnosis, management and staging of EB-associated cutaneous SCCs based on available evidence and expert consensus.• They highlight the importance of a holistic multidisciplinary approach to the management of EB-associated SCCs, where patient involvement in decision making is paramount.

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“…A number of different techniques of minimally invasive surgery have been used in EB SCCs, including Mohs micrographic surgery, rush paraffin sections (‘slow Mohs’) and chemosurgery …”

Section: Surgical Treatmentmentioning

confidence: 99%