Persistent <scp><i>Helicobacter pylori</i></scp> infection leads to elevated fasting plasma glucose level: A retrospective cohort study based on a nondiabetes Chinese population

You, Ningning; Chen, Y.; Yan, Xiaonan; Gu, Bin-Bin; Wang, Jun; Zhang, Jinshun

doi:10.1111/jgh.16275

Cited by 2 publications

(2 citation statements)

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“…You N, Chen Y et al have indicated that H. pylori infection is an independent risk factor for increased fasting plasma glucose (FPG) levels in non-diabetic (DM) individuals. Persistent H. pylori infection leads to elevated levels of FPG[34].…”

Section: Disussionmentioning

confidence: 99%

“…However, Helicobacter pylori infection is not related to obesity-related parameters, glucose tolerance, or systolic blood pressure [13].There are also studies with opposing conclusions, which explored the relationship between Helicobacter pylori infection and fasting plasma glucose (FPG) levels in a non-diabetic population. The study found that Helicobacter pylori infection is an independent risk factor for increased FPG levels, and persistent infection can lead to increased levels of FPG and triglycerides/high-density lipoprotein (TG/HDL), which could be risk factors for diabetes [14].Recent research findings on the association between Helicobacter pylori infection and insulin resistance and metabolic syndrome have been contradictory. Therefore, a comprehensive meta-analysis was conducted, which included 22 studies involving 206,911 subjects.…”

Section: Introductionmentioning

confidence: 99%

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The Association between Helicobacter pylori Infection and Triglyceride-Glucose (TyG) Index in US Adults: a restrospective cross-sectional study

Fu,

zhao,

Chen

et al. 2023

Preprint

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BackgroundThe Triglyceride-glucose (TyG) index is an emerging marker for insulin resistance and metabolic syndrome. Helicobacter pylori, a bacterium associated with gastrointestinal diseases, may also influence metabolic risk profiles. This study aimed to investigate the relationship between the TyG index and Helicobacter pylori infection among a representative sample of adults.MethodsA total of 9965 participants from the NHANES 1999-2000 cycle were involved from March 1, 1999, to December 1, 2000.A cross-sectional analysis was conducted on 3797 participants. The baseline characteristics according to the quartile of the TyG index were evaluated.Multivariate binary logistic regression models were constructed to analyze the independent effects of the TyG index on Helicobacter pylori infection. A two-piecewise binary logistic regression model was used to explore the non-linear relationship between the TyG index and Helicobacter pylori, with an inflection point identified. Subgroup analyses were performed to assess the trends of effect sizes across different variables including age, sex, glucose levels, body mass index (BMI), and chronic kidney disease (CKD).ResultsMultivariate analysis indicated a linear relationship between the TyG index and Helicobacter pylori infection, suggesting differential influence of the TyG index on Helicobacter pylori infection. Subgroup analysis demonstrated significant interactions only for a few variables, with all p-values for interaction below 0.05.ConclusionsThe study suggests a linear association between the TyG index and Helicobacter pylori infection.These findings have implications for understanding the metabolic influences on Helicobacter pylori infection and may guide targeted interventions for at-risk populations.

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Section: Disussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association between Helicobacter pylori Infection and Triglyceride-Glucose (TyG) Index in US Adults: a restrospective cross-sectional study

Fu,

zhao,

Chen

et al. 2023

Preprint

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Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

Ye,

Feng,

et al. 2023

Helicobacter

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The microbiota actively and extensively participates in the regulation of human metabolism, playing a crucial role in the development of metabolic diseases. Helicobacter pylori (H. pylori), when colonizing gastric epithelial cells, not only induces local tissue inflammation or malignant transformation but also leads to systemic and partial changes in host metabolism. These shifts can be mediated through direct contact, toxic components, or indirect immune responses. Consequently, they influence various molecular metabolic events that impact nutritional status and iron absorption in the host. Unraveling the intricate and diverse molecular interaction links between H. pylori and human metabolism modulation is essential for understanding pathogenesis mechanisms and developing targeted treatments for related diseases. However, significant challenges persist in comprehensively understanding the complex association networks among H. pylori itself, the infected host's status, the host microbiome, and the immune response. Previous metabolomics research has indicated that H. pylori infection and eradication may selectively shape the metabolite and microbial profiles of gastric lesions. Yet, it remains largely unknown how these diverse metabolic pathways, including isovaleric acid, cholesterol, fatty acids, and phospholipids, specifically modulate gastric carcinogenesis or affect the host's serum metabolism, consequently leading to the development of metabolic‐associated diseases. The direct contribution of H. pylori to metabolisms still lacks conclusive evidence. In this review, we summarize recent advances in clinical evidence highlighting associations between chronic H. pylori infection and metabolic diseases, as well as its potential molecular regulatory patterns.

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Persistent Helicobacter pylori infection leads to elevated fasting plasma glucose level: A retrospective cohort study based on a nondiabetes Chinese population

Abstract: Author contributions: SJZ made great contributions to the concept, design and data acquisition of the article. NNY and YC was mainly involved in data analysis. XDY, BBG, and JW were involved in article writing. Financial support: No funding was received.

Cited by 2 publications

References 35 publications

The Association between Helicobacter pylori Infection and Triglyceride-Glucose (TyG) Index in US Adults: a restrospective cross-sectional study

The Association between Helicobacter pylori Infection and Triglyceride-Glucose (TyG) Index in US Adults: a restrospective cross-sectional study

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

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