Persistent paraneoplastic neurologic syndrome after successful therapy of Hodgkin's disease

Maslovsky, Igor; Volchek, Lior; Blumental, Roger; Ducach, A.; Lugassy, Gilles

doi:10.1034/j.1600-0609.2001.00240.x

Cited by 23 publications

(10 citation statements)

References 29 publications

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“…However, it may also precede the clinical presentation of malignancy by many years [5]. The pathogenesis of the paraneoplastic syndromes is not completely understood.…”

Section: Discussionmentioning

confidence: 99%

Chronic Paraneoplastic Cutaneous Syndrome Preceding an Indolent Variant of Mantle Cell Lymphoma: Favorable Response to Rituximab

Nemets¹,

Ronen

Lugassy³

2006

Acta Haematol

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Mantle cell lymphoma (MCL) is an aggressive type of malignant lymphoma with short median survival despite conventional therapy. We describe the unusual case of a 66-year-old man with a chronic skin rash which preceded the occurrence of an indolent MCL by 2 years. Repeated skin biopsies did not show involvement by the lymphoma. Short therapy with rituximab resulted in the complete and lasting resolution of the cutaneous lesions.

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“…However, it may also precede the clinical presentation of malignancy by many years [5]. The pathogenesis of the paraneoplastic syndromes is not completely understood.…”

Section: Discussionmentioning

confidence: 99%

Chronic Paraneoplastic Cutaneous Syndrome Preceding an Indolent Variant of Mantle Cell Lymphoma: Favorable Response to Rituximab

Nemets¹,

Ronen

Lugassy³

2006

Acta Haematol

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“…Paraneoplastic neuropathies are seen in association with 4% to 5% of cancers [1-3]. Hodgkin’s lymphoma is also associated with multiple paraneoplastic neuropathies like cerebellar degeneration, acute inflammatory demyelinating polyneuropathy (Guillain-Barré), CIDP, chorea and ataxia, subacute sensory neuropathy, motor neuron disease, myasthenia gravis, stiff person syndrome and brachial neuropathy [1,4].…”

Section: Discussionmentioning

confidence: 99%

“…Hodgkin’s lymphoma is also associated with multiple paraneoplastic neuropathies like cerebellar degeneration, acute inflammatory demyelinating polyneuropathy (Guillain-Barré), CIDP, chorea and ataxia, subacute sensory neuropathy, motor neuron disease, myasthenia gravis, stiff person syndrome and brachial neuropathy [1,4]. The most common neurological syndrome described in the literature is subacute cortical cerebellar degeneration with more than 50 cases reported so far [1,5,6]. Demyelinating neuropathies are very rare [3,7-9].…”

Section: Discussionmentioning

confidence: 99%

Hodgkin’s lymphoma presenting as a complex paraneoplastic neurological syndrome: a case report

2013

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IntroductionParaneoplastic neuropathies are rare. They are often difficult to diagnose, especially when they precede the diagnosis of cancer. Hodgkin's lymphoma is associated with multiple paraneoplastic neurological syndromes, of which demyelinating polyneuropathies are very unusual. Association with chronic inflammatory demyelinating polyneuropathy is even more uncommon.Case presentationWe report the rare case of a 74-year-old Caucasian man who presented with a complex neurological syndrome and was eventually diagnosed with the nodular sclerosing variant of Hodgkin's lymphoma. With timely diagnosis and early institution of treatment of the underlying malignancy, our patient began to show gradual improvement of his symptoms.ConclusionHodgkin's lymphoma is associated with several paraneoplastic neurological syndromes. Sometimes it can be the only presenting feature of an underlying Hodgkin's lymphoma, posing a diagnostic challenge. Prompt oncologic treatment and immunotherapy can be beneficial if instituted early in the course of the disease.

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“…The most common cause of new-onset neuropathy is progression of tumor or recurrence of such tumor (1,2). Cancer can directly cause neuropathies or indirectly result in paraneoplastic neuropathies (3,4). Signs and symptoms from neuropathies attributable to cancer can help with cancer diagnosis and contribute to disease prognosis.…”

Section: Inrtoductionmentioning

confidence: 98%

Radiation-induced peripheral neuropathies: Etiopathogenesis, risk factors, differential diagnostics, symptoms and treatment

Vasić

2007

Arch Oncol

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The success of radiation oncology has lead to longer patient survival. This provides a greater opportunity for radiation injuries of the peripheral nerves to develop. Peripheral neuropathy in cancer patients may result from either tumor recurrence or as a consequence of radiation therapy. Distinguishing between radiation injury and cancer disease recurrence as a cause of nerve dysfunction may be difficult. In this article the etiopathogenesis of radiation-induced peripheral neuropathies has been discussed as well as main risk factors, symptoms and method of treatment

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Persistent paraneoplastic neurologic syndrome after successful therapy of Hodgkin's disease

Cited by 23 publications

References 29 publications

Chronic Paraneoplastic Cutaneous Syndrome Preceding an Indolent Variant of Mantle Cell Lymphoma: Favorable Response to Rituximab

Chronic Paraneoplastic Cutaneous Syndrome Preceding an Indolent Variant of Mantle Cell Lymphoma: Favorable Response to Rituximab

Hodgkin’s lymphoma presenting as a complex paraneoplastic neurological syndrome: a case report

Radiation-induced peripheral neuropathies: Etiopathogenesis, risk factors, differential diagnostics, symptoms and treatment

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