2006
DOI: 10.1016/j.jpain.2006.01.458
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Persistent Pain Produces Stress-like Alterations in Hippocampal Neurogenesis and Gene Expression

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Cited by 148 publications
(125 citation statements)
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“…One of the major insights that emerge from these studies is that both NK-1 receptor and BDNF mRNA levels are significantly attenuated by acute (formalin injection) or chronic pain (CFA injection), in accordance with the results initiated by acute or chronic restraint stress. These findings in the hippocampus are in sharp contrast to those uncovered in the spinal cord [25,186] , potentially reflecting varied roles of these neuromodulators in the de- but not acute pain (a single formalin injection), significantly reduced the neurogenesis in the DG area of the HF, measured by bromedeoxyuridine staining [196] , similar to previous observations from various stress models [192,197] . This paininduced decrease in hippocampal cell proliferation was recently confirmed by another immunoblotting study, comparing the apoptotic effects of chronic inflammatory pain and immobilization stress in rats [198] .…”
Section: Egr1 Expression the Zinc Finger Transcription Factorsupporting
confidence: 84%
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“…One of the major insights that emerge from these studies is that both NK-1 receptor and BDNF mRNA levels are significantly attenuated by acute (formalin injection) or chronic pain (CFA injection), in accordance with the results initiated by acute or chronic restraint stress. These findings in the hippocampus are in sharp contrast to those uncovered in the spinal cord [25,186] , potentially reflecting varied roles of these neuromodulators in the de- but not acute pain (a single formalin injection), significantly reduced the neurogenesis in the DG area of the HF, measured by bromedeoxyuridine staining [196] , similar to previous observations from various stress models [192,197] . This paininduced decrease in hippocampal cell proliferation was recently confirmed by another immunoblotting study, comparing the apoptotic effects of chronic inflammatory pain and immobilization stress in rats [198] .…”
Section: Egr1 Expression the Zinc Finger Transcription Factorsupporting
confidence: 84%
“…Implicit within these observations is the hypothesis that chronic pain may regulate the expression of NK-1 receptor and BDNF in the hippocampus in a manner similar to that exerted by stress. To address this issue, McCarson's lab has conducted lots of work by using multiple approaches, such as solution hybridization-nuclease protection assays [24,25,195] , and in-situ hybridization [196] . One of the major insights that emerge from these studies is that both NK-1 receptor and BDNF mRNA levels are significantly attenuated by acute (formalin injection) or chronic pain (CFA injection), in accordance with the results initiated by acute or chronic restraint stress.…”
Section: Egr1 Expression the Zinc Finger Transcription Factormentioning
confidence: 99%
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“…Indeed, an overlap exists in components of the pain neuromatrix and brain regions involved in cognitive processing (e.g., anterior cingulate cortex, insular cortex, periaqueductal gray) (14). Together with the demonstrated changes in neuroplasticity [e.g., gray matter volume reduction (15)(16)(17)] and dysregultated neurochemistry [e.g., decreased levels of brain-derived neurotrophic factor (18), increased levels of gamma-aminobutric acid (19), increased levels of pro-inflammatory cytokines (20)], these pain-induced changes in resource utilization may (in part) explain (pain-related) cognitive impairment in chronic pain patients.…”
Section: Participants and Assessmentsmentioning
confidence: 99%
“…Repeated exposure to low-dose formaldehyde increased basal corticosterone levels and produced stresslike alterations in hippocampal neurogenesis in rats 43) . In the present study, significant elevation of serum cortisol levels was observed at the 5th formalin application when the magnitude of skin reactions to formalin was most prominent.…”
Section: Discussionmentioning
confidence: 94%