Persistent pain after mastectomy with reconstruction

Hickey, Oonagh T.; Nugent, Nora; Burke, S.; Hafeez, Parvaiz; Mudrakouski, Aliaksandr L.; Shorten, George

doi:10.1016/j.jclinane.2011.01.009

Cited by 68 publications

(45 citation statements)

References 31 publications

(53 reference statements)

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“…Lee et al [44] suggested that rs4818 and rs6269, but not rs4680, may be linked to long-lasting postsurgical pain after the removal of a third molar in a Caucasian Irish population. However, Hickey et al [45] suggested that there may be a link between rs4680 and persistent pain after mastectomy in Irish patients, and Fernández-de-lasPeñas et al [46] showed an association between rs4680 and elevated pain ratings in mastectomized Spanish breast cancer survivors. Similarly, the COMT polymorphism was not found to affect the gene Â pain interaction with mood in postdiscectomy sciatic pain patients [86].…”

Section: Miscellaneous Studiesmentioning

confidence: 99%

Catechol-O-methyltransferase gene polymorphism and chronic human pain

Tammimäki

Männistö

2012

Pharmacogenetics and Genomics

146

109

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In human studies, low COMT (catechol-O-methyltransferase) activity has been associated with increased sensitivity to acute clinical preoperative or postoperative pain. We explored the association between the COMT genotype and three chronic pain conditions: migrainous headache, fibromyalgia, or chronic widespread pain and chronic musculoskeletal pain. Furthermore, we evaluated whether COMT genotype affects the efficacy of opioids in chronic pain. After a systematic literature review, we carried out meta-analyses on the three chronic pain conditions. The efficacy of opioids was evaluated using a systematic review only. The meta-analyses showed that fibromyalgia or chronic widespread pain is the only type of chronic pain that could be associated with the COMT single nucleotide polymorphism rs4680 (Val158Met). Met158, which results in the low-activity variant of COMT, is the risk allele. In chronic clinical pain, the effect of the COMT polymorphism depends on the pain condition. Low COMT activity is not associated with migrainous headache or chronic musculoskeletal pain conditions, but it may increase the risk for fibromyalgia or chronic widespread pain. Low COMT activity increases opioid receptors and enhances opioid analgesia and adverse effects in some cancer pains. Findings from animal studies that have utilized COMT inhibitors elucidate the mechanism behind these findings. In rodent pain models, COMT inhibitors are pronociceptive, except for neuropathic pain models, where nitecapone was found to be antiallodynic. The complex interplay between enhanced adrenergic and dopaminergic activity in different parts of the nociceptive system probably explains the complicated actions of low COMT activity.

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Section: Miscellaneous Studiesmentioning

confidence: 99%

Catechol-O-methyltransferase gene polymorphism and chronic human pain

Tammimäki

Männistö

2012

Pharmacogenetics and Genomics

146

109

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“…Burckhardt and Jones (2005) used the short-form of the MPQ and found that breast cancer survivors employed the terms "aching", "tender", and "sharp" most. Hickey et al (2011) investigated persistent pain following mastectomy with breast reconstruction and found that the participants used the terms "itching", "burning", "tightness", "aching", "piercing", "annoying", "exhausting" and "miserable" most. In contrast, a recent study found a weak association between breast reconstructive surgery and the development of chronic pain after a mastectomy (De Oliveira et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Characterization of chronic pain in breast cancer survivors using the McGill Pain Questionnaire

Ferreira

Guirro

Dibai‐Filho

et al. 2015

Journal of Bodywork and Movement Therapies

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“…The Met158 allele is associated with an advantage in memory and attention tasks (worrier strategy) [36]. Individuals homozygous for the Met158 allele display increased pain sensitivity but lower l-opioid system activation during sustained pain [34,37,38] and the Met158 allele has been associated with chronic pain disorders [39,40], acute postoperative pain [29,41], chronic post-surgical pain [42], and opioid-induced hyperalgesia (OIH) [43]. The effect of COMT genotype on pain processing seems to become apparent only when pain modulation is challenged, such as occurs after repeated pain stimulation [44], or after remifentanil exposure in healthy volunteers Met158 homozygous [43].…”

Section: Oprm1 and Epidural Sufentanil For Labor Analgesiamentioning

confidence: 99%

The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

Landau

Ortner

Vuilleumier

2013

Curr Anesthesiol Rep

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In an attempt to provide some explanation for the observed differences in pain perception and analgesic requirements during labor and delivery between women, the idea that genetic variability is an important factor has emerged over the past decade. Bearing in mind the challenges posed when evaluating pain during childbirth as a phenotype, recent findings in the field of genetics and obstetric anesthesia are presented in this review; in particular those related to differences in labor analgesia requirements between women, the response to opioids after cesarean delivery, as well as theories on why post-cesarean pain may be different from other types of post-surgical pain.

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Persistent pain after mastectomy with reconstruction

Cited by 68 publications

References 31 publications

Catechol-O-methyltransferase gene polymorphism and chronic human pain

Catechol-O-methyltransferase gene polymorphism and chronic human pain

Characterization of chronic pain in breast cancer survivors using the McGill Pain Questionnaire

The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

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