2020
DOI: 10.1186/s12969-019-0376-8
|View full text |Cite
|
Sign up to set email alerts
|

Persistent osteoarticular pain in children: early clinical and laboratory findings suggestive of acute lymphoblastic leukemia (a multicenter case-control study of 147 patients)

Abstract: BackgroundThe aim of this study was to identify early clinical and laboratory features that distinguish acute lymphoblastic leukemia (ALL) from juvenile idiopathic arthritis (JIA) in children presenting with persistent bone or joint pain for at least 1 month.MethodsWe performed a multicenter case-control study and reviewed medical records of children who initially presented with bone or joint pain lasting for at least 1 month, all of whom were given a secondary diagnosis of JIA or ALL, in four French Universit… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
14
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 26 publications
(14 citation statements)
references
References 23 publications
0
14
0
Order By: Relevance
“…Delay in access to PRh care is a widespread problem and remains so even when specialist services are available [ 4 , 5 ]. The impact of delay is considerable and given the highly effective treatments available [ 1 , 3 , 23 ], it is more imperative than ever that efforts are made to facilitate earlier diagnosis and prompt referral to specialist care.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Delay in access to PRh care is a widespread problem and remains so even when specialist services are available [ 4 , 5 ]. The impact of delay is considerable and given the highly effective treatments available [ 1 , 3 , 23 ], it is more imperative than ever that efforts are made to facilitate earlier diagnosis and prompt referral to specialist care.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, our data was collected nearly 10 years ago (data collection ended July 2011) and so elements of the findings may be seen as no longer relevant, given changes in care. However, we know that delays in diagnosis remain a major problem impacting on clinical care [ 12 ] and are a priority to address in many parts of the world [ 31 ]; we suggest that the factors identified are still central to influencing that delay.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Even though leukemia cells have not directly infiltrated the synovium, children may report arthralgia for the periosteal lesions of the juxta-articular bones [7]. According to the literature, 18% of ALL children suffer from arthropathy, with a similar distribution between arthritis (9%) and arthralgia (9%).…”
Section: Pathogenesis Of Pain In Childhood Leukemiamentioning
confidence: 99%
“…Many clinical and epidemiologic research studies suggest an infectious etiology for KD (Rowley, 2017;Shulman & Rowley, 2015). Viral respiratory infections are common in KD patients (Maggio, Fabiano & Corsello, 2019;Rosenfeld et al, 2020). KD is an immunemediated echo of viral infection and viral infection might trigger KD (Rigante, 2020;Rosenfeld et al, 2020).…”
Section: Introductionmentioning
confidence: 99%