Persistent organic pollutants in matched breast milk and infant faeces samples

Chen, Yiqin; Wang, Xianyu; Li, Yan; Toms, Leisa-Maree; Gallen, Michael; Hearn, Laurence; Aylward, Lesa L.; McLachlan, Michael S.; Sly, Peter D.; Mueller, Jochen F.

doi:10.1016/j.chemosphere.2014.09.076

Cited by 23 publications

(20 citation statements)

References 25 publications

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“…PCBs and PBDE congeners were analyzed following the protocol established in our center (Chen et al, 2015). Identification and quantification were performed using Thermo Fisher HRGC 1310-HRMS DFS operated in MID mode.…”

Section: Instrumental Analysismentioning

confidence: 99%

Coupling passive sampling with in vitro bioassays and chemical analysis to understand combined effects of bioaccumulative chemicals in blood of marine turtles

et al. 2015

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Section: Instrumental Analysismentioning

confidence: 99%

Coupling passive sampling with in vitro bioassays and chemical analysis to understand combined effects of bioaccumulative chemicals in blood of marine turtles

et al. 2015

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“…The folded aluminium foil sheet was then sealed inside a plastic resealable bag and stored in a freezer at the participant’s home until transportation to the laboratory (on ice, in a cool bag). A detailed description of faecal sample collection and transportation has been provided previously (Chen et al, 2015). Faecal samples were stored at −20 °C until analysis.…”

Section: Methodsmentioning

confidence: 99%

Persistent organic pollutants in infants and toddlers: Relationship between concentrations in matched plasma and faecal samples

Chen

Sjödin

McLachlan

et al. 2017

Environment International

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Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13 ± 4.8 months), including a repeat sample time point for 13 infants (~5 months apart). We observed higher rates of POP quantification in faeces (2 g dry weight) than in plasma (0.5 mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (Cf) and blood (Cb) were correlated (r > 0.74, P < 0.05) for p.p′-dichlorodiphenyldichloroethylene (p,p′-DDE), 2,3′,4,4′,5-pentachlorobiphenyl (PCB118), 2,2′,3,4,4′,5′-penta-chlorobiphenyl (PCB138) and 2,2′,4,4′,5,5′-pentachlorobiphenyl (PCB153). We determined faeces:plasma concentration ratios (Kfb), which can be used to estimate Cb from measurements of Cf for infants/toddlers. For a given chemical, the variation in Kfb across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in Kfb over the first year of life. The strong correlations between Cf and Cb demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in Kfb could improve the precision and utility of this technique.

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“…One missing link is the role of persistent organic pollutants, which have been strongly associated with endocrine disruption (57) that may result in abnormal growth patterns and increased risk for obesity (58)(59)(60) . Other effects are low birth weight, motor and visual defects and delayed cognitive development (61) . Persistent organic pollutants being lipophilic, preferentially bio-accumulate in breast milk (62) and are transferred from the mother to the infant during breast-feeding (61) .…”

Section: Evaluating the Impact Of Environmental Factors On Nutritionamentioning

confidence: 99%

Using stable isotope techniques in nutrition assessments and tracking of global targets post-2015

2017

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Stable isotopes are non-radioactive, safe and are applied for various purposes in human health assessment in trace amounts that minimally disturb normal physiology. The International Atomic Energy Agency supports the use of stable isotope techniques to design and evaluate interventions addressing malnutrition in all its forms with focus on infant and young child feeding; maternal and adolescent nutrition; diet quality; prevention and control of non-communicable diseases; healthy ageing and gut function. These techniques can be used to objectively measure: (1) amount of human milk consumed and whether an infant is exclusively breastfed; (2) body composition in the context of re-feeding programmes for moderate and severe acute malnutrition and as an indicator of the risk for obesity; (3) bioavailability and bioconversion of pro-vitamin A and vitamin A body stores following vitamin A intervention programmes; (4) absorption and retention of iron, zinc and protein; (5) total energy expenditure for validation of physical activity measurement and dietary assessment tools and (6) diagnosis of Helicobacter pylori. Stable isotope techniques will be invaluable in the tracking of global targets on exclusive breast-feeding childhood obesity and anaemia among women. Efforts are underway to make nuclear techniques more affordable, field-friendly and less invasive, and to develop less sophisticated but precise equipment. Advocacy for the wide adoption of the techniques is needed.

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Persistent organic pollutants in matched breast milk and infant faeces samples

Cited by 23 publications

References 25 publications

Coupling passive sampling with in vitro bioassays and chemical analysis to understand combined effects of bioaccumulative chemicals in blood of marine turtles

Coupling passive sampling with in vitro bioassays and chemical analysis to understand combined effects of bioaccumulative chemicals in blood of marine turtles

Persistent organic pollutants in infants and toddlers: Relationship between concentrations in matched plasma and faecal samples

Using stable isotope techniques in nutrition assessments and tracking of global targets post-2015

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