Using stable isotope techniques in nutrition assessments and tracking of global targets post-2015

Owino, Victor; Slater, Christine; Loechl, Cornelia

doi:10.1017/s0029665117000295

Cited by 23 publications

(31 citation statements)

References 50 publications

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“…To generate an evidence base for breastfeeding recommendations among food-insecure mothers, we explored breastfeeding practices among 119 mother-infant dyads in western Kenya at 6 and 24 weeks postpartum using the deuterium oxide dose-to-the-mother (DTM) technique to quantify breast milk intake. The DTM technique is more precise than test weighing (Coward, Whitehead, Sawyer, Prentice, & Evans, 1979) and also provides an objective measure of whether an infant is exclusively breastfed (Owino, Slater, & Loechl, 2017). Our first objective was to explore the relationship between food insecurity and EBF.…”

Section: Introductionmentioning

confidence: 99%

Greater household food insecurity is associated with lower breast milk intake among infants in western Kenya

Miller

Young

Boateng

et al. 2019

Maternal & Child Nutrition

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Household food insecurity has been hypothesized to negatively impact breastfeeding practices and breast milk intake, but this relationship has not been rigorously assessed. To generate an evidence base for breastfeeding recommendations among food‐insecure mothers in settings where HIV is highly prevalent, we explored infant feeding practices among 119 mother–infant dyads in western Kenya at 6 and 24 weeks postpartum. We used the deuterium oxide dose‐to‐the‐mother technique to determine if breastfeeding was exclusive in the prior 2 weeks, and to quantify breast milk intake. Sociodemographic data were collected at baseline and household food insecurity was measured at each time point using the Household Food Insecurity Access Scale. Average breast milk intake significantly increased from 721.3 g/day at 6 weeks postpartum to 961.1 g/day at 24 weeks postpartum. Household food insecurity at 6 or 24 weeks postpartum was not associated with maternal recall of exclusive breastfeeding (EBF) in the prior 24 hr or deuterium oxide‐measured EBF in the prior 2 weeks at a significance level of 0.2 in bivariate models. In a fixed‐effects model of quantity of breast milk intake across time, deuterium oxide‐measured EBF in the prior 2 weeks was associated with greater breast milk intake (126.1 ± 40.5 g/day) and every one‐point increase in food insecurity score was associated with a 5.6 (±2.2)‐g/day decrease in breast milk intake. Given the nutritional and physical health risks of suboptimal feeding, public health practitioners should screen for and integrate programs that reduce food insecurity in order to increase breast milk intake.

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Section: Introductionmentioning

confidence: 99%

Greater household food insecurity is associated with lower breast milk intake among infants in western Kenya

Miller

Young

Boateng

et al. 2019

Maternal & Child Nutrition

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“…With the advancement in use of stable isotopes, there is likely to be a significant growth in knowledge on age‐absorption parameters over the next few years (Owino et al . ).…”

Section: Personalising Nutrition For Older Adultsmentioning

confidence: 97%

Personalising nutrition for older adults: The InCluSilver project

2018

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Ageing is associated with a decline in health and an increase in age-related disease. However, the rate of biological ageing is not consistent between individuals and is not completely determined by genes. The rate of ageing and health decline is influenced by the environment and can be manipulated experimentally (e.g. by regulating metabolism). This highlights the potential for appropriate nutrition in order to maintain metabolic health as we age. Such interventions could consequently increase health-span and quality of life of an ageing population. However, public health advice about nutrition, such as consumption of two portions of fish each week (one of which should be oily) and eating at least five portions of fruit and vegetables daily, is focused on the population as a whole. It may not address an older individual's specific nutrient requirements to maintain health during ageing. The InCluSilver project, supported by the European Union Horizon 2020 programme, seeks to address this challenge through personalised nutrition for older adults. Personalised dietary recommendations should be fine-tuned to an individual's age, health, phenotype/genotype, activity, preferences and/or motivations, and framed by evidence from clinical trials. However, currently the dietary evidence base in older adults is small. Long-term studies that investigate dietary modifications in older individuals who are malnourished or over-nourished are needed to inform potential strategies. A wider food perspective will be necessary for successful implementation of personalised nutrition to support healthy ageing. This may include technologies that enable users to monitor their nutritional and health status for the purpose of motivating dietary adherence.

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“…Nuclear techniques, especially stable isotope techniques have been applied for decades to help in understanding the biological pathways underpinning human health including assessment of body composition, energy expenditure, nutrient absorption and bioavailability in addition to assessment of infant and young child feeding practices [ 56 ]. Stable isotope techniques have also been applied in the detection of food contaminants including arsenic [ 57 ] and mycotoxins [ 58 ].…”

Section: The Role Of Nuclear/isotopic Techniques In Characterisatimentioning

confidence: 99%

“…Cross sectional manual expression of human milk may not depict habitual consumption by the infant. The ability to quantify exposure to POPs from breast milk can be enhanced by using a safe, objective and non-invasive stable isotope technique that measures human milk intake over a two-week period, the deuterium oxide dose-to-mother technique [ 56 , 62 ]. A lactating mother drinks a dose of deuterium oxide (D 2 O), which is distributed throughout her body within a few hours and is incorporated into her milk.…”

Section: The Role Of Nuclear/isotopic Techniques In Characterisatimentioning

confidence: 99%

“…Stable isotopes have been applied widely to measure the absorption and bioavailability of iron, zinc, and vitamin A. The development of a method to assess the digestion and bioavailability of proteins and amino acids from food legumes intrinsically labelled with stable isotopes is at an advanced stage ([ 56 ], Preston et al Unpublished).…”

Section: Assessment Of Metabolic Changes Linked To Exposure To Edcmentioning

confidence: 99%

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Elucidating Adverse Nutritional Implications of Exposure to Endocrine-Disrupting Chemicals and Mycotoxins through Stable Isotope Techniques

2018

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Multiple drivers of the double burden of malnutrition (DBM) include a rapid shift from predominantly plant-based diets to energy-dense foods based on meats, milk, animal fats and vegetable oils. The shift to overweight and obesity is driven by increased exposure to mass media, urbanization, technological advances in food processing, rising income and increased population density associated with increased access to cheap foods. At the same time, undernutrition persists mainly due to food insecurity and lack of access to safe water, sanitation and adequate health care. All known nutrition interventions result in only one third reduction in stunting. Little consideration has been given to hazardous exposure to endocrine disrupting chemicals (EDCs) and microbial toxins as major components of the malnutrition-causal framework. These hazards include microbial toxins, for example, mycotoxins, and environmental pollutants such as persistent organic pollutants (POPs), some of which are known to disrupt the endocrine system. These hazards sit at the cross road of undernutrition and overweight and obesity since the exposure cuts across the critical window of opportunity (the first 1000 days). In this review, we update on the role of food and environmental contaminants, especially EDCs and aflatoxins, in child growth and on the implications for metabolic dysfunction and disease risk in later life, and discuss potential applications of nuclear and isotopic techniques to elucidate the underlying biological mechanisms, outcome indicators, as well as occurrence levels.

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Using stable isotope techniques in nutrition assessments and tracking of global targets post-2015

Cited by 23 publications

References 50 publications

Greater household food insecurity is associated with lower breast milk intake among infants in western Kenya

Greater household food insecurity is associated with lower breast milk intake among infants in western Kenya

Personalising nutrition for older adults: The InCluSilver project

Elucidating Adverse Nutritional Implications of Exposure to Endocrine-Disrupting Chemicals and Mycotoxins through Stable Isotope Techniques

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