Persistent organic pollutants exposure during pregnancy, maternal gestational weight gain, and birth outcomes in the mother–child cohort in Crete, Greece (RHEA study)

Vafeiadi, Marina; Vrijheid, Martine; Fthenou, Eleni; Chalkiadaki, Georgia; Rantakokko, Panu; Kiviranta, Hannu; Kyrtopoulos, Soterios A.; Chatzi, Leda; Kogevinas, Manolis

doi:10.1016/j.envint.2013.12.015

Cited by 88 publications

(41 citation statements)

References 50 publications

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“…In the present study, serum concentrations of organochlorine pesticides were comparable to those reported previously in some populations in Tunisia (Ben Hassine et al, 2014;Ennaceur and Driss, 2010) and other Mediterranean countries, such as Egypt (Ahmed et al, 2002), Italy (Bergonzi et al, 2009), Spain (Llop et al, 2010), or Greece (Vafeiadi et al, 2014). However, PCB concentrations were in general higher than those reported in other Tunisian populations and were comparable to those reported in more industrialized Mediterranean countries such as Italy (Bergonzi et al, 2009) and Spain (Llop et al, 2010), which may be attributable to the recent rapid technological development of Tunisia.…”

Section: Discussionsupporting

confidence: 85%

Risk of female breast cancer and serum concentrations of organochlorine pesticides and polychlorinated biphenyls: A case–control study in Tunisia

Arrebola

Belhassen

Artacho‐Cordón

et al. 2015

Science of The Total Environment

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Section: Discussionsupporting

confidence: 85%

Risk of female breast cancer and serum concentrations of organochlorine pesticides and polychlorinated biphenyls: A case–control study in Tunisia

Arrebola

Belhassen

Artacho‐Cordón

et al. 2015

Science of The Total Environment

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“…While some research has found that gestational weight gain (GWG) may confound the association between maternal exposure to persistent organic pollutants and birth weight (23), other investigators have noted that their findings differed according to GWG stratum (24, 25). In light of this literature, we conducted 2 additional analyses with the results 1) adjusted for GWG as a continuous variable and 2) stratified by GWG category, defined according to the US Institute of Medicine (26).…”

Section: Methodsmentioning

confidence: 99%

Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight

Ashley‐Martin¹,

Dodds²,

Arbuckle³

et al. 2017

Am. J. Epidemiol.

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Perfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals that have been widely used in the production of common household and consumer goods for their nonflammable, lipophobic, and hydrophobic properties. Inverse associations between maternal or umbilical cord blood concentrations of perfluorooctanoic acid and perfluorooctanesulfonate and birth weight have been identified. This literature has primarily examined each PFAS individually without consideration of the potential influence of correlated exposures. Further, the association between PFAS exposures and indicators of metabolic function (i.e., leptin and adiponectin) has received limited attention. We examined associations between first-trimester maternal plasma PFAS concentrations and birth weight and cord blood concentrations of leptin and adiponectin using data on 1,705 mother-infant pairs from the Maternal Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada birth cohort study that recruited women between 2008 and 2011. Bayesian hierarchical models were used to quantify associations and calculate credible intervals. Maternal perfluorooctanoic acid concentrations were inversely associated with birth weight z score, though the null value was included in all credible intervals (log10 β = −0.10, 95% credible interval: −0.34, 0.13). All associations between maternal PFAS concentrations and cord blood adipocytokine concentrations were of small magnitude and centered around the null value. Follow-up in a cohort of children is required to determine how the observed associations manifest in childhood.

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“…There was some evidence for attenuation of the effect size with increasing tertiles of tree cover. Vafeidi et al [33] measured serum levels of multiple POPs, including pesticides, polychlorinated diphenyls and polybrominated diphenyl ether (PBDE)-47, among pregnant women during the first Fig. 2 The dynamic pregnancy and early-life external exposome [12].…”

Section: External Pregnancy Exposome Studiesmentioning

confidence: 99%

The Pregnancy Exposome

Robinson

Vrijheid

2015

Curr Envir Health Rpt

Self Cite

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The exposome concept takes a holistic approach facilitated by new and emerging technologies to describe 'the totality of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome'. It provides a framework to advance the environmental epidemiology field that has until now focused almost exclusively on single-exposure health effects. The exposome includes an external domain, measured by methods including geo-spatial modelling, questionnaire and biomonitoring of external exposures while the internal domain is commonly assessed through molecular omics platforms. The internal domain, in part, reflects the biological response to the external domain. New statistical frameworks are required to integrate and assess exposome-health effects. The pregnancy period is a key starting point to describe the dynamic exposome, due to its heightened sensitivity and potential lifetime impact. A handful of studies have started to move towards an exposome approach in assessing the effects of the multiple exposures during pregnancy on child development. New research projects are underway to test the exposome approach on a large scale.

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Persistent organic pollutants exposure during pregnancy, maternal gestational weight gain, and birth outcomes in the mother–child cohort in Crete, Greece (RHEA study)

Cited by 88 publications

References 50 publications

Risk of female breast cancer and serum concentrations of organochlorine pesticides and polychlorinated biphenyls: A case–control study in Tunisia

Risk of female breast cancer and serum concentrations of organochlorine pesticides and polychlorinated biphenyls: A case–control study in Tunisia

Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight

The Pregnancy Exposome

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