The Pregnancy Exposome

Robinson, Oliver; Vrijheid, Martine

doi:10.1007/s40572-015-0043-2

Cited by 81 publications

(47 citation statements)

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“…In an effort to characterize the exposome, or the totality of non-genetic exposures that a person experiences from conception until death along with the associated biological response, assessing biomarkers of exposure among women of childbearing age can help quantify a mother's contribution to their child's exposome during sensitive developmental periods (National Institute of Environmental Health Sciences [NIEHS], 2015b; Robinson and Vrijheid, 2015; Wild, 2005). Many chemical analytes within the same usage or chemical class are densely correlated (Rappaport, 2012; Robinson et al, 2015; Sun et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Rosofsky

Janulewicz

Thayer

et al. 2017

Environmental Research

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Background Current exposure assessment research does not sufficiently address multi-pollutant exposure and their correlations in human media. Understanding the extent of chemical exposure in reproductive-aged women is of particular concern due to the potential for in utero exposure and fetal susceptibility. Objectives The objectives of this study were to characterize concentrations of chemical biomarkers during preconception and examine correlations between and within chemical classes. Methods We examined concentrations of 135 biomarkers from 16 chemical classes in blood and urine from 73 women aged 18–40 enrolled in Snart Foraeldre/Milieu, a prospective cohort study of pregnancy planners in Denmark (2011–2014). We compared biomarker concentrations with United States similarly-aged, non-pregnant women who participated in the National Health and Nutrition Environmental Survey (NHANES) and with other international biomonitoring studies. We performed principal component analysis to examine biomarker correlations. Results The mean number of biomarkers detected in the population was 92 (range: 60–108). The most commonly detected chemical classes were phthalates, metals, phytoestrogens and polycyclic aromatic hydrocarbons. Except blood mercury, urinary barium and enterolactone, geometric means were higher in women from NHANES. Chemical classes measured in urine generally did not load on a single component, suggesting high between-class correlation among urinary biomarkers, while there is high within-class correlation for biomarkers measured in serum and blood. Conclusions We identified ubiquitous exposure to multiple chemical classes in reproductive-aged Danish women, supporting the need for more research on chemical mixtures during preconception and early pregnancy. Inter- and intra-class correlation between measured biomarkers may reflect common exposure sources, specific lifestyle factors or shared metabolism pathways.

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Section: Introductionmentioning

confidence: 99%

“…PCA results may also identify the extent to which chemical exposures share common sources and pathways or jointly contribute to disease. While PCA has been commonly used in the occupational health literature, few investigators have used PCA in exposure assessment in women of childbearing age (Robinson and Vrijheid, 2015). …”

Section: Introductionmentioning

confidence: 99%

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Rosofsky

Janulewicz

Thayer

et al. 2017

Environmental Research

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“…There is also a need for improved assessment of exposure variability, including minute, daily, and yearly variability, as well as peak and intermittent exposures, in multiple, critical life stages, including the targeted development of standardized external exposure metrics for use in utero, in early childhood, in adolescence, and in senescence (82,108). Analytical platforms based on high-resolution mass spectrometry have also been applied in quantitative and qualitative analysis of contaminants in various exposure matrices such as surface water and house dust (77,84).…”

Section: Methodological and Technological Improvementsmentioning

confidence: 99%

Assessing the Exposome with External Measures: Commentary on the State of the Science and Research Recommendations

Turner

Nieuwenhuijsen

Anderson

et al. 2017

Annu. Rev. Public Health

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The exposome comprises all environmental exposures that a person experiences from conception throughout the life course. Here we review the state of the science for assessing external exposures within the exposome. This article reviews (a) categories of exposures that can be assessed externally, (b) the current state of the science in external exposure assessment, (c) current tools available for external exposure assessment, and (d ) priority research needs. We describe major scientific and technological advances that inform external assessment of the exposome, including geographic information systems; remote sensing; global positioning system and geolocation technologies; portable and personal sensing, including smartphone-based sensors and assessments; and self-reported questionnaire assessments, which increasingly rely on Internet-based platforms. We also discuss priority research needs related to methodological and technological improvement, data analysis and interpretation, data sharing, and other practical considerations, including improved assessment of exposure variability as well as exposure in multiple, critical life stages.

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“…Teeth offer a unique advantage of accurate fetal organic chemical exposure assessment on a temporal scale [33]. This is not true for conventional biomarkers such as maternal bio-matrices due to variations in placental transport or for cord blood due to short half-lives of many chemicals [34, 35]. …”

Section: Components Of the Exposome That Are Measurable In Tooth Matrmentioning

confidence: 99%

The tooth exposome in children's health research

Andra

Austin

Arora

2016

Current Opinion in Pediatrics

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Purpose of review The exposome concept proposes a comprehensive assessment of environmental exposures from the prenatal period onwards. However, determining exposure timing especially over the prenatal period is a major challenge in environmental epidemiologic studies. Recent findings For decades teeth have been used to estimate long-term cumulative exposure to metals. Recently developed high-dimensional analytical methods that combine sophisticated histological and chemical analysis to precisely sample tooth layers that correspond to specific life stages have the potential to reconstruct the exposome in the second and third trimesters of prenatal development and during early childhood. Summary A retrospective temporal exposomic approach that precisely measures exposure intensity and timing during prenatal and early childhood development would substantially aid epidemiologic investigations, particularly case–control studies of rare health outcomes.

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The Pregnancy Exposome

Cited by 81 publications

References 50 publications

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Assessing the Exposome with External Measures: Commentary on the State of the Science and Research Recommendations

The tooth exposome in children's health research

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