Persistent oral candidosis by non‐<i>albicans Candida</i>strains including<i>Candida glabrata</i>in a human immunodeficiency virus‐infected patient observed over a period of 6 years

Hoegl, L.; Thoma-Greber, Eva; Röcken, Martin; Körting, Hans Christian

doi:10.1111/j.1439-0507.1998.tb00347.x

Cited by 18 publications

(12 citation statements)

References 15 publications

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“…In contrast, there are several reports on oropharyngeal Candida infections due to C. glabrata [24,25]. In the present study, the isolation frequency of C. glabrata increased from 14.1% in 2006–2007 to 32.1% in 2012–2013 when assessed by the number of patients, indicating a similar tendency observed in Japanese OC patients.…”

Section: Discussionsupporting

confidence: 51%

Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006–2007 and 2012–2013

et al. 2014

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BackgroundThe isolation frequency and susceptibility to antifungal agents of oral Candida isolates from patients with oral candidiasis (OC) were compared between studies conducted in 2006–2007 and 2012–2013.MethodsA total158 strains was isolated from 112 patients who visited Kagoshima University Hospital for the treatment of OC during the 14-month period from February 2012 and March 2013, and evaluated on the isolation frequency of each Candida strain and the susceptibility against antifungal drugs as compared to those evaluated in 2006–2007.ResultsThere was a higher frequency of xerostomia as a chief complaint and of autoimmune disease in the 2012–2013 study than in the 2006–2007 study. More than 95% of Candida isolates were C. albicans and C. glabrata. In addition, the proportion of the latter increased from 12.3% in the 2006–2007 study to 23.4% in the 2012–2013 study, while the proportion of the former decreased from 86.2% to 72.8%, respectively. C. albicans was isolated in almost all patients, while C. glabrata was only isolated concomitantly with C. albicans. Minimal inhibitory concentrations (MICs) were not significantly different between groups with a few exceptions. Candida isolates, of which MICs surpassed break points, apparently increased for miconazole and itraconazole against C. glabrata in the 2012–2013 study, but this was not statistically significant. As a result, more cases of autoimmune disease, a greater number of C. glabrata isolates, and higher resistance to azoles were seen in the 2012–2013 study than in the 2006–2007 study.ConclusionThese data indicate that with recent increases in C. glabrata infection, a causative fungus of OC, and in C. glabrata resistance to azoles, caution is needed in the selection of antifungal drugs for the treatment of OC.

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Section: Discussionsupporting

confidence: 51%

Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006–2007 and 2012–2013

et al. 2014

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“…The most interesting fact is that C. tropicalis and C. dubliniensis were not isolated. This is a surprising observation in view of reports from developed countries, where non-C. albicans candidiasis is a major problem in HIV/AIDS patients (9,11,12,18,19). Antifungal drug prophylaxis is rarely practiced in India, and this may be the reason for this observation.…”

mentioning

confidence: 93%

Susceptibility Pattern and Molecular Type of Species-Specific Candida in Oropharyngeal Lesions of Indian Human Immunodeficiency Virus-Positive Patients

Lattif¹,

Banerjee²,

Prasad³

et al. 2004

J Clin Microbiol

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A study of oropharyngeal candidiasis (OPC) in Indian human immunodeficiency virus (HIV)/AIDS patients was conducted over a period of 15 months. This study revealed that 75% of the HIV/AIDS patients had OPC. MIC testing revealed that 5% of the Candida isolates were fluconazole resistant. A correlation between CD4(+)-T-cell counts and development of OPC in HIV/AIDS patients was also observed. Molecular typing of C. albicans isolates showed that all were genetically unrelated.

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“…The introduction of highly active antiretroviral therapy (HAART) including PI has been accompanied by a reduction in the frequency of many of the secondary infections caused by HIV infection, including oral lesions (2,(8)(9)(10)12,19). Infection by C. albicans generally involves adherence and colonization of superficial tissues (13,22,24).…”

Section: Resultsmentioning

confidence: 99%

“…3223, Fax: (+44 01792) 513054. E-mail: nadjarm@yahoo.com including HIV protease inhibitor (PI), in the treatment of HIVinfected patient (8,19,26). This has been attributed to Candida proteases belonging the same protease class as HIV protease.…”

Section: Introductionmentioning

confidence: 99%

HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system

Melo¹,

Vilela²,

Jorge³

et al. 2006

Braz. J. Microbiol.

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Declining incidence of oropharyngeal candidosis and opportunistic infections over recent years can be attributed to the use of highly active anti-retroviral therapy (HAART). Infection with C. albicans generally involves adherence and colonization of superficial tissues. During this process, budding yeasts are able to transform to hyphae and penetrate into the deep tissue. Using the biocell tracer system, C. albicans hyphal growth was dynamically observed at the cellular level. Ritonavir was effective in the inhibition of hyphal growth with growth rate of 0.8 μm/min. This study showed the in vitro effect of HIV anti-retroviral drug on the growth rate of the C. albicans hyphae.

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Persistent oral candidosis by non‐albicans Candidastrains includingCandida glabratain a human immunodeficiency virus‐infected patient observed over a period of 6 years

Cited by 18 publications

References 15 publications

Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006–2007 and 2012–2013

Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006–2007 and 2012–2013

Susceptibility Pattern and Molecular Type of Species-Specific Candida in Oropharyngeal Lesions of Indian Human Immunodeficiency Virus-Positive Patients

HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system

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