Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006–2007 and 2012–2013

Kamikawa, Yoshiaki; Mori, Youichirou; Nagayama, Tomohiro; Fujisaki, Junichi; Hirabayashi, Daisuke; Sakamoto, Ryoichi; Hamada, Tomofumi; Sugihara, Kazumasa

doi:10.1186/1472-6831-14-14

Cited by 21 publications

(17 citation statements)

References 22 publications

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“…Biofilm formation by C. albicans is involved in its resistance to conventional antifungal drugs [13]. The rate of oral C. glabrata infections has been increasing recently, and these infections have shown potent resistance to azole antifungal agents [14,15]. In addition, mixed infection by C. albicans and C. glabrata has been commonly observed in the oral cavity [16,17].…”

Section: Discussionmentioning

confidence: 99%

High Rate of Oral Candida Detection in Dependent Japanese Older People

Miyata

Shigeishi

et al. 2020

Geriatrics

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The aim of this study was to clarify the association between oral Candida detection and the dependency status of older people. This study included 31 older people aged ≥70 years who had a certified need for long-term care or support and received care in a local day care center; it also included 27 independent older patients aged ≥70 years who visited Hiroshima University Hospital. Oral Candida was detected by a polymerase chain reaction using swab samples from the tongue surface. Oral moisture was significantly reduced in dependent older people, compared with independent older people (p = 0.003). There was a weak negative relationship between numbers of bacteria and levels of oral moisture (Spearman’s rank correlation coefficient; R = −0.29, p = 0.01). Dependent older people exhibited a significantly higher rate of Candida albicans detection (35.5%) compared with independent older people (11.1%). Dependent older people also exhibited a higher rate of concurrent detection of both C. albicans and Candida glabrata (32.3%) compared with independent older people (11.1%), but this difference was not statistically significant. Thus, dependent older people may be more susceptible to oral C. albicans infection, compared with independent older people. Good oral hygiene is necessary to prevent oral Candida infection in dependent older people.

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Section: Discussionmentioning

confidence: 99%

High Rate of Oral Candida Detection in Dependent Japanese Older People

Miyata

Shigeishi

et al. 2020

Geriatrics

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“…C. glabrata is rarely isolated alone and is often isolated with other Candida species such as C. albicans . Moreover, C. glabrata is resistant to azoles, antifungal drugs; thus, relapse of infections with this organism is a problem clinically . Because C. glabrata has low infectivity for mice, establishment of an experimental animal system has been difficult.…”

Section: Silkworm Infection Models With Pathogenic Fungimentioning

confidence: 99%

Silkworm as an experimental animal for research on fungal infections

Matsumoto

Sekimizu

2019

Microbiology and Immunology

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Silkworm, Bombyx mori, has various advantages as an experimental animal, such as the low cost for rearing and fewer ethical problems. Models utilizing silkworms of infection with pathogenic bacteria have been established for identification of genes encoding virulence factors by large‐scale in vivo screening. In this review, we describe recent progress in the study of silkworm infection models for elucidating the mechanisms of fungi infection. Silkworm infection models have been established for Candida albicans, Candida tropicalis, Candida glabrata and Cryptococcus neoformans, which are yeast type fungi, and Aspergillus fumigatus, Arthroderma vanbreuseghemii, Arthroderma benhamiae, Microsporum canis, Trichophyton rubrum, and Rhizopus oryzae, which are filamentous fungi. Novel genes encoding virulence factors in C. albicans and C. glabrata have been identified by using the silkworm infection models. We here outline the benefits of using silkworm infection models and a strategy for identifying the genes responsible for pathogenicity of microorganisms such as fungi. © 2019 The Authors. Microbiology and Immunology Published by The Societies and John Wiley & Sons Australia, Ltd.

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“…Oral candidiasis is a fungal disease mainly caused by C. albicans [ 7 , 8 ]. However, an increase in the involvement of C. glabrata has been reported over the past few years [ 8 , 9 , 12 , 13 , 14 ]. The adhesive strength of C. glabrata to acrylic resin is twice that of C. albicans [ 7 ]; therefore, it is more frequently isolated from the mucosal surfaces of dentures in elderly patients [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…C. glabrata cannot invade the epithelium by itself because it is a non-dimorphic yeast, but co-infection with C. albicans promotes invasion into the epithelium [ 9 , 32 ]. The proportion of C. glabrata resistant to azole antifungal agents is increasing [ 13 ]. In addition, there are reports that infection with C. glabrata alone or in combination with C. albicans is more resistant to azole antifungal agents than that with C. albicans alone [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Candida glabrata has been detected in immunocompromised patients with head and neck cancer and HIV, and those with denture stomatitis [ 9 , 10 , 11 ]. However, an increase in the number of patients with C. glabrata infection and oral candidiasis has been reported recently [ 8 , 9 , 12 , 13 , 14 ]. Oral candidiasis caused by C. glabrata is intractable because C. glabrata has intrinsically low susceptibility and is able to easily become resistant to azole antifungal agents, thus making it difficult to treat [ 13 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Storage Temperature and pH on the Antifungal Effects of Commercial Oral Moisturizers against Candida albicans and Candida glabrata

et al. 2020

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Background and objectives: Oral moisturizers have been used to treat dry mouth. This study aimed to investigate the effects of storage temperature and pH on the antifungal effects of oral moisturizers against Candida albicans and Candida glabrata. Materials and Methods: Thirty-one oral moisturizers and amphotericin B (AMPH-B) were stored at 25 and 37 °C for 1 week. Subsequently, they were added to cylindrical holes in 50% trypticase soy agar plates inoculated with C. albicans and C. glabrata (107 cells/ml). The antifungal effects were evaluated based on the sizes of the growth-inhibitory zones formed. Two-way analysis of variance was used to determine the effects of storage temperature and pH on the growth-inhibitory zones. Results: Significant differences in the effects of storage temperature and pH of the moisturizers were observed against C. albicans and C. glabrata. The growth-inhibitory zones of samples stored at 37 °C and with neutral pH were significantly larger than those stored at 25 °C and with acidic pH, respectively. The sizes of the zones formed by most of the oral moisturizers were larger than those formed by AMPH-B (concentration, 0.63 µg/ml). Conclusion: The antifungal effects of oral moisturizers against C. albicans and C. glabrata were affected by their storage temperature and pH.

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Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006–2007 and 2012–2013

Cited by 21 publications

References 22 publications

High Rate of Oral Candida Detection in Dependent Japanese Older People

High Rate of Oral Candida Detection in Dependent Japanese Older People

Silkworm as an experimental animal for research on fungal infections

Effects of Storage Temperature and pH on the Antifungal Effects of Commercial Oral Moisturizers against Candida albicans and Candida glabrata

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