Persistent nasal carriers of Acinetobacter baumannii in long-term-care facilities

Liou, Ming-Li; Chen, Kuan-Hsueh; Yeh, Hui‐Ling; Lai, Chun-Yi; Chen, Changhua

doi:10.1016/j.ajic.2017.02.005

Cited by 19 publications

(21 citation statements)

References 22 publications

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“…We isolated A. baumannii mainly from the nose, which could suggest that the bacterium has a tropism to the nasal mucosa. Consistent with this, A. baumannii has been isolated from human nasal samples with rates from 54 to 92% in long term facilities (Liou et al, 2017). However, it has been shown in another study that the colonization of the human digestive tract was also high (41%) in a nosocomial context (Corbella et al, 1996).…”

Section: Discussionmentioning

confidence: 64%

Seasonal Occurrence and Carbapenem Susceptibility of Bovine Acinetobacter baumannii in Germany

et al. 2019

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Acinetobacter baumannii is one of the leading causes of nosocomial infections in humans. To investigate its prevalence, distribution of sequence types (STs), and antimicrobial resistance in cattle, we sampled 422 cattle, including 280 dairy cows, 59 beef cattle, and 83 calves over a 14-month period. Metadata, such as the previous use of antimicrobial agents and feeding, were collected to identify putative determining factors. Bacterial isolates were identified via MALDI-TOF/MS and PCR, antimicrobial susceptibility was evaluated via VITEK2 and antibiotic gradient tests, resistance genes were identified by PCR. Overall, 15.6% of the cattle harbored A. baumannii , predominantly in the nose (60.3% of the A. baumannii isolates). It was more frequent in dairy cows (21.1%) than in beef cattle (6.8%) and calves (2.4%). A seasonal occurrence was shown with a peak between May and August. The rate of occurrence of A. baumannii was correlated with a history of use of 3rd generation cephalosporins in the last 6 months prior to sampling Multilocus sequence typing (Pasteur scheme) revealed 83 STs among 126 unique isolates. Nine of the bovine STs have previously been implicated in human infections. Besides known intrinsic resistance of the species, the isolates did not show additional resistance to the antimicrobial substances tested, including carbapenems. Our data suggest that cattle are not a reservoir for nosocomial A. baumannii but carry a highly diverse population of this species. Nevertheless, some STs seem to be able to colonize both cattle and humans.

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Section: Discussionmentioning

confidence: 64%

Seasonal Occurrence and Carbapenem Susceptibility of Bovine Acinetobacter baumannii in Germany

et al. 2019

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“…ranged from 48.60% (SC) to 21.53% (NH). Our previous study showed that the rate of nasal carriage for A. baumannii was approximately 54–92% at SC 23 whereas that for S. aureus was approximately 0–15%. We suspect that most of the Staphylococcus spp.…”

Section: Discussionmentioning

confidence: 94%

“…Richly diverse commensal microbiota can provide protection to the host 1,11–14 , maintaining health by increasing resistance to infection 15 . Residents of HCIs and LTCFs are critical reservoirs for microorganisms, especially human-related microorganisms 23,26 . The bacterial fingerprints of surface microbiota represent a unique mix of bacterial communities found in various environments 27 .…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial outbreaks have been reported in LTCFs 22 and may result in the dissemination of multiple-drug-resistant microorganisms from LTCFs to the community or to the wider healthcare delivery system through acute care hospitals in the area. In a prospective study, a high incidence of human-related microorganisms of the nasal carriage was discovered at LTCFs 23 . A few studies have also reported the presence of other human-related microorganisms in the nasal cavity 23–25 .…”

Section: Introductionmentioning

confidence: 99%

“…In a prospective study, a high incidence of human-related microorganisms of the nasal carriage was discovered at LTCFs 23 . A few studies have also reported the presence of other human-related microorganisms in the nasal cavity 23–25 . Nowadays, there is still a lack of a comprehensive and detailed analysis of the relationship between nasal microbiota and environmental microbiota.…”

Section: Introductionmentioning

confidence: 99%

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Diversity of nasal microbiota and its interaction with surface microbiota among residents in healthcare institutes

Chen

Liou

Lee

et al. 2019

Sci Rep

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Nasal microbial communities may have crucial implications for human health, including for residents of healthcare institutes (HCIs). Factors that determine the diversity of nasal microbiota in HCIs remain unclear. Herein, we used 16S rRNA amplicon sequencing to investigate the relationship between nasal and surface microbiota in three HCIs. Participants were classified into a hospitalised or nonhospitalised group based on their most recent date of hospitalisation. A total of 88 nasal samples and 83 surface samples were analysed. Dysgonomonas and Corynebacterium were the most abundant taxa in the surface and nasal samples, respectively. Significant differences were discovered in microbiota diversity among HCIs when comparing the surface and nasal samples. Fifteen taxa were identified as present in all the surface and nasal samples. SourceTracker analysis revealed that the ventilation conditions of environment might be associated with the proportion of shared microbial communities between nasal and surface. Additionally, as compared with the nonhospitalised group, the hospitalised group had a higher proportion of surface microbiota in their nasal samples, which might lead to a higher risk of human-related microorganisms or pathogens colonising the nasal cavity. The data suggest that nasal bacterial diversity could be influenced by both health status and living environment. Our results therefore highlight the importance of the indoor environment for HCI residents.

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Contamination of healthcare environment by carbapenem-resistant Acinetobacter baumannii

Cruz-López

Martínez-Meléndez²,

Villarreal-Treviño³

et al. 2022

The American Journal of the Medical Sciences

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Persistent nasal carriers of Acinetobacter baumannii in long-term-care facilities

Cited by 19 publications

References 22 publications

Seasonal Occurrence and Carbapenem Susceptibility of Bovine Acinetobacter baumannii in Germany

Seasonal Occurrence and Carbapenem Susceptibility of Bovine Acinetobacter baumannii in Germany

Diversity of nasal microbiota and its interaction with surface microbiota among residents in healthcare institutes

Contamination of healthcare environment by carbapenem-resistant Acinetobacter baumannii

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