Persistent lymphadenopathy associated with hypertransfusion in sickle-cell disease

Morgan, Jane E.; Waring, Nell Pape; Daul, C.B.; Ohene‐Frempong, Kwaku; deShazo, Richard D.

doi:10.1016/0091-6749(85)90762-6

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…In addition, the C D 4 /C D 8 ratio was normal. Conflicting data were reported for each one of these parameters in S C A [13][14][15][16][17] which could be related with the number o f previous transfusions [12]. On the other hand, there are few data for splenectomized in dividuals [16,31] and our results in general agree with these studies.…”

Section: Discussionsupporting

confidence: 82%

Are the Changes of Lymphocyte Subsets in Sickle Cell Anemia due to the Loss of Splenic Function?

Donadi

Falcão²

1988

Acta Haematol

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Lymphocyte subsets and K cell activity were evaluated in sickle cell anemia (SCA) and in splenec-tomized patients. Results showed that the number of total lymphocytes, T lymphocyte subsets and B lymphocytes were increased in SCA. However, individuals who had undergone splenectomy did not exhibit all these abnormalities, suggesting that the lack of the spleen apparently was not the unique factor responsible for the lymphocyte abnormalities seen in SCA patients.

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Section: Discussionsupporting

confidence: 82%

Are the Changes of Lymphocyte Subsets in Sickle Cell Anemia due to the Loss of Splenic Function?

Donadi

Falcão²

1988

Acta Haematol

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“…A variety of laboratory findings suggestive of immunologic abnormalities have been reported in transfused hemoglobinopathy patients [ll-161. However, the prevalence of HIV antibodies and lymphadenopathy in this group of individuals is still under investigation [lo, [17][18][19]. Although we were unable to examine our patient's blood donors for AIDS or to test them for HIV antibodies, the most likely cause of her acquired immunodeficiency syndrome was the administration of packed red blood cells 4 years before her demise.…”

Section: Discussionmentioning

confidence: 99%

Excess HLA antigens after transfusion of sickle cell patient with AIDS

et al. 1987

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A woman with sickle cell-hemoglobin C disease developed the acquired immunodeficiency syndrome (AIDS), possibly as the result of blood transfusions administered 4 years earlier. Three months after subsequent transfusions, she had excess HLA-A and DR antigens (triplets) on her circulating lymphocytes. Three of her first-degree relatives were HLA-typed, and none had excess antigens. Family studies also indicated that the patient had at least one HLA-A antigen that was probably not inherited. These findings suggest the possibility that transient hemopoietic engraftment can occur in transfused sickle cell patients with AIDS.

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Selective compartmental dominance: an explanation for a noninfectious, multifactorial etiology for acquired immune deficiency syndrome (AIDS), and a rationale for ozone therapy and other immune modulating therapies

Shallenberger

1998

Medical Hypotheses

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Persistent lymphadenopathy associated with hypertransfusion in sickle-cell disease

Cited by 5 publications

References 34 publications

Are the Changes of Lymphocyte Subsets in Sickle Cell Anemia due to the Loss of Splenic Function?

Are the Changes of Lymphocyte Subsets in Sickle Cell Anemia due to the Loss of Splenic Function?

Excess HLA antigens after transfusion of sickle cell patient with AIDS

Selective compartmental dominance: an explanation for a noninfectious, multifactorial etiology for acquired immune deficiency syndrome (AIDS), and a rationale for ozone therapy and other immune modulating therapies

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