Persistent human hepatitis B virus infection in cynomolgus monkeys: A novel animal model in the search for a cure?

Bukh, Jens; Lanford, Robert E.; Purcell, Robert H.

doi:10.1002/hep.26560

Cited by 8 publications

(5 citation statements)

References 20 publications

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“…Increased concentration of ALT may indicate hepatocytes damage. Recently, MCM were found to have a naturally occurring chronic hepatitis B virus infection . In another study of MCM, wild‐caught monkeys had slightly higher ALT concentration than captive‐bred monkeys, but the reported mean ALT concentration for captive‐bred monkeys was within the RI range reported in this study.…”

Section: Discussioncontrasting

confidence: 46%

Reference intervals for biochemical and haematological analytes of juvenile captive‐bred long‐tailed macaques (Macaca fascicularis) from Mauritius with examination of the effects of individual characteristics using principal component analysis

Naiken

Griffiths

Hurdial

et al. 2016

J of Medical Primatology

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Section: Discussioncontrasting

confidence: 46%

Reference intervals for biochemical and haematological analytes of juvenile captive‐bred long‐tailed macaques (Macaca fascicularis) from Mauritius with examination of the effects of individual characteristics using principal component analysis

Naiken

Griffiths

Hurdial

et al. 2016

J of Medical Primatology

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“…Despite recent advances using transgenic mice, 51 research on hepatitis B cure is hampered by the lack of suitable animal models for persistent HBV infection. 52 Challenges to develop primate models for persistent hepatitis B infection include ethical constraints on the usage of chimpanzees, the endangered status of woolly monkeys, and nonpersistent infection with WMHBV in spider monkeys. 52 Whether macaques may prove useful animal models for chronic hepatitis B remains to be confirmed.…”

Section: Discussionmentioning

confidence: 99%

“…52 Challenges to develop primate models for persistent hepatitis B infection include ethical constraints on the usage of chimpanzees, the endangered status of woolly monkeys, and nonpersistent infection with WMHBV in spider monkeys. 52 Whether macaques may prove useful animal models for chronic hepatitis B remains to be confirmed. 53 Capuchin monkeys easily breed in captivity 54 and are among the most widely used New World primates in biomedical research.…”

Section: Discussionmentioning

confidence: 99%

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses

Souza

König

Rasche

et al. 2018

Journal of Hepatology

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The origins of HBV are unclear. The new orthohepadnavirus species from Brazilian capuchin monkeys resembled HBV in elicited infection patterns and could infect human liver cells using the same receptor as HBV. Evolutionary analyses suggested that primate HBV-related viruses might have emerged in African ancestors of New World monkeys millions of years ago. HBV was associated with hominoid primates, including humans and apes, suggesting evolutionary origins of HBV before the formation of modern humans. HBV genotypes found in American natives were divergent from those found in American monkeys, and likely introduced along prehistoric human migration. Our results elucidate the evolutionary origins and dispersal of primate HBV, identify a new orthohepadnavirus reservoir, and enable new perspectives for animal models of hepatitis B.

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“…Finally, it was shown that a Macaca fascicularis colony from Mauritius Island was naturally infected with a human HBV isolate (Dupinay et al 2013). Macaques might become an alternative model to chimpanzees for the study of therapeutic approaches against HBV infections (Bukh et al 2013). …”

Section: Establishing the Chimpanzee As An Hbv Model Systemmentioning

confidence: 99%

The Chimpanzee Model for Hepatitis B Virus Infection

Wieland

2015

Cold Spring Harbor Perspectives in Medicine

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Even before the discovery of hepatitis B virus (HBV), it was known that chimpanzees (Pan troglodytes) are susceptible to human hepatitis viruses. The chimpanzee is the only primate animal model for HBV infections. Much like HBV-infected human patients, chimpanzees can developacute andchronic HBVinfectionsand consequent hepatitis. Chimpanzees alsodevelop a cellular immune response similar to that observed in humans. For these reasons, the chimpanzee has proven to be an invaluable model for investigations on HBV-driven disease pathogenesis and also the testing of novel antiviral therapies and prophylactic approaches.

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Persistent human hepatitis B virus infection in cynomolgus monkeys: A novel animal model in the search for a cure?

Cited by 8 publications

References 20 publications

Reference intervals for biochemical and haematological analytes of juvenile captive‐bred long‐tailed macaques (Macaca fascicularis) from Mauritius with examination of the effects of individual characteristics using principal component analysis

Reference intervals for biochemical and haematological analytes of juvenile captive‐bred long‐tailed macaques (Macaca fascicularis) from Mauritius with examination of the effects of individual characteristics using principal component analysis

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses

The Chimpanzee Model for Hepatitis B Virus Infection

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