Persistent Health Effects of Dioxin Contamination in Herbicide Production

Headache caused by handling the pesticide Antracol Combi WP 76: a case report

“…The search was extended by a review of bibliographies from pertinent original reports of data and review articles. Headache is a common side effect in cases of poisoning with pesticides, accompanied with other side effects [7,[10][11][12][13][14][15][16][17][18]. The side effects suffered by our patient were limited to headache with nausea and vomiting.…”

Other Toxic Chemicals as Potential Chemical Warfare Agents

“…This is a limiting factor for its use as a CW. Dioxin in the organism is bound to lipids and concentration of dioxin in plasma fat in persons exposed to dioxin was 100-1,000× higher than that of normal population (Neuberger et al, 1999;Pelclová et al, 2011;Klement et al, 2013). It should be mentioned that dioxin is one of the polychlorinated biphenyls and dibezofurans that appears to be problematic for the environment (Sofronov et al, 2001;Bajgar, 2006).…”

Polychlorinated dibenzo-p-dioxins and the human immune system: 4. Studies on two Spanish families with increased body burdens of highly chlorinated PCDDs

“…Overall levels were highest in the parents and eldest children and lowest in the son born not long after first presentation of the family and presumably exposed in utero or in the short period on mother's milk. Unlike other episodes of accidental exposure to dioxins, TCDD levels were no greater than in control populations (Hansson et al, 1995a;Neuberger et al, 1999;Papke et al, 1996). PCDFs had fallen greater than PCDDs and contributed little to the body burden and so were not included in Table 1.…”

“…The persistence of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in the environment, food and people (Geyer et al, 2002;Kahn et al, 1988;Needham et al, 1994;Needham et al, 1999;Neuberger et al, 1999;Neubert et al, 1990;Tohyama, 2002) continues to be of concern, but it has proven difficult to ascertain the true risks for human health with respect to the various congeners and mixtures of these contaminants (called here collectively, dioxins), especially at a low dose range (Neubert, 1997/98). Originally, most of the concern was based on experimental evidence showing an excessive toxicity, including some carcinogenicity, of the most potent chemical, 2,3,7,, in the liver of rodents, and in humans on the induction of chloracne (Baccarelli et al, 2005), skin lesions for which a special mouse strain may be a model (Panteleyev et al, 1997).…”