Persistent Alcohol Abuse and Late Outcome in Head Injury

Sabhesan, S.; Arumugham, R.; Ramasamy, P.; Natarajan, M.

doi:10.1177/0975156419870203

Cited by 7 publications

(3 citation statements)

References 2 publications

(2 reference statements)

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“…[ 79 80 ] Alcohol use has had a significant association with head injury and cognitive deficits. [ 81 82 ] Persistent drinking is associated with persisting memory deficits in head injured alcohol dependent patients. [ 82 ] Mild intellectual impairment has been demonstrated in patients with bhang and ganja dependence.…”

Section: Epidemiologymentioning

confidence: 99%

Substance use and addiction research in India

Murthy

Manjunatha

Subodh

et al. 2010

Indian J Psychiatry

141

108

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Substance use patterns are notorious for their ability to change over time. Both licit and illicit substance use cause serious public health problems and evidence for the same is now available in our country. National level prevalence has been calculated for many substances of abuse, but regional variations are quite evident. Rapid assessment surveys have facilitated the understanding of changing patterns of use. Substance use among women and children are increasing causes of concern. Preliminary neurobiological research has focused on identifying individuals at high risk for alcohol dependence. Clinical research in the area has focused primarily on alcohol and substance related comorbidity. There is disappointingly little research on pharmacological and psychosocial interventions. Course and outcome studies emphasize the need for better follow-up in this group. While lack of a comprehensive policy has been repeatedly highlighted and various suggestions made to address the range of problems caused by substance use, much remains to be done on the ground to prevent and address these problems. It is anticipated that substance related research publications in the Indian Journal of Psychiatry will increase following the journal having acquired an ‘indexed’ status.

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Section: Epidemiologymentioning

confidence: 99%

Substance use and addiction research in India

Murthy

Manjunatha

Subodh

et al. 2010

Indian J Psychiatry

141

108

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“…Overall, HE and AA had similar rates of survival and neurosurgical intervention but notably higher LOS. There have been many factors linking alcohol use disorder and increased LOS such as alcohol withdrawal including seizure 56 – 58 , increased risk of hospital complications and infection, particularly of pneumonia 59 , and pre-injury cerebral atrophy secondary to neurotoxicity 60 , 61 . Taken together, a slow and potentially turbulent recovery may explain the increased LOS in AA.…”

Section: Discussionmentioning

confidence: 99%

Identification of clinically relevant patient endotypes in traumatic brain injury using latent class analysis

Qiu,

Zador,

Lannon

et al. 2024

Sci Rep

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Traumatic brain injury (TBI) is a complex condition where heterogeneity impedes the advancement of care. Understanding the diverse presentations of TBI is crucial for personalized medicine. Our study aimed to identify clinically relevant patient endotypes in TBI using latent class analysis based on comorbidity data. We used the Medical Information Mart for Intensive Care III database, which includes 2,629 adult TBI patients. We identified five stable endotypes characterized by specific comorbidity profiles: Heart Failure and Arrhythmia, Healthy, Renal Failure with Hypertension, Alcohol Abuse, and Hypertension. Each endotype had distinct clinical characteristics and outcomes: The Heart Failure and Arrhythmia endotype had lower survival rates than the Renal Failure with Hypertension despite featuring fewer comorbidities overall. Patients in the Hypertension endotype had higher rates of neurosurgical intervention but shorter stays in contrast to the Alcohol Abuse endotype which had lower rates of neurosurgical intervention but significantly longer hospital stays. Both endotypes had high overall survival rates comparable to the Healthy endotype. Logistic regression models showed that endotypes improved the predictability of survival compared to individual comorbidities alone. This study validates clinical endotypes as an approach to addressing heterogeneity in TBI and demonstrates the potential of this methodology in other complex conditions.

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“…In addition t o the behavioural consequences, frontal lobe damage gave rise to neuropsychological impairment (Luria, 1973;Nauta, 1972;Pribram, 1973). Relatives also perceived the cognitive disturbances as the most significant determinant of the burden at one year after head injury Sabhesan et al, 1987). The lack of difference in cognitive dysfunction in both groups might indicate that neurological recovery of focal damage was fairly complete during the period of follow-up or that injury t o other areas also could be equally disturbing.…”

Section: Discussionmentioning

confidence: 99%

Frontal Lobe Injuries-Psychological Outcome and Experienced Burden

Sabhesan¹,

Premila²,

Natarajan³

1988

Indian Journal of Psychological Medicine

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Injury to frontal lobe results in disorganized social behaviour. The cognitive disturbances and the behavioural sequelae entail a severe degree of burden to the family members. Twenty patients w i t h assault injuries to the frontal lobe were prospectively followed up for a period of eighteen months. The degree of maladjustment was measured using Dysfunction Analysis Questionnaire and the family burden was quantitated using Family Burden Interview Schedule. The results were compared against t h e control group of patients who had sustained assault injuries to other parts of the brain. Relation between the severity of t h e brain damage and the outcome measures was studied. The importance of factors other than neurological damage and possibly-envlronrnental. is stressed.

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Persistent Alcohol Abuse and Late Outcome in Head Injury

Cited by 7 publications

References 2 publications

Substance use and addiction research in India

Substance use and addiction research in India

Identification of clinically relevant patient endotypes in traumatic brain injury using latent class analysis

Frontal Lobe Injuries-Psychological Outcome and Experienced Burden

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