Persistence to antihypertensive drug treatment in Swedish primary healthcare

Qvarnström, Miriam; Kahan, Thomas; Kieler, Helle; Brandt, Lena; Hasselström, Jan; Boström, Kristina Bengtsson; Manhem, Karin; Hjerpe, Per; Wettermark, Björn

doi:10.1007/s00228-013-1555-z

Cited by 53 publications

(41 citation statements)

References 47 publications

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“…Studies have suggested that across both developed and LMIC countries there are considerable problems with adherence to antihypertensive medicines [18][19][20][21][22][23]. Overall, only approximately 14 to 25 % of treated patients achieve optimal blood pressure control, with 50 % of patients appearing to stop taking their antihypertensive treatments within the first year [24,25].…”

Section: Introductionmentioning

confidence: 99%

Patient-related beliefs and adherence toward their medications among the adult hypertensive outpatients in Tanzania

et al. 2017

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This version is available at https://strathprints.strath.ac.uk/59545/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output. AbstractIntroduction: Hypertension is a leading global health problem requiring lifelong treatment. However, adherence to antihypertensive medicines is a problem, higher among developing countries. Consequently, there is a need to determine current adherence rates and their associations among developing countries to plan future initiatives. Methods: Cross-sectional study among adult outpatients with essential hypertension in Tanzania. Pre-designed questionnaires were used to gather information on adherence rates and patient-related beliefs. The main outcome measure was adherence. Results: 180 participants were included, with females making up 65%. High adherence rates in 54% of patients. Patients' belief about their medication and its necessity were higher in the high adherent group and concerns about their medicines and their necessity higher in the low adherent group. Conclusion: Adherence rates were low compared to a suggested level ≥ 80 %.

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Section: Introductionmentioning

confidence: 99%

Patient-related beliefs and adherence toward their medications among the adult hypertensive outpatients in Tanzania

et al. 2017

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“…Accordingly, persistence to antihypertensive therapy is increased in the presence of cardiovascular comorbidities. 13,32 Also, at the time of the study a blood pressure o130/80 mm Hg was recommended in patients with diabetes and cardiovascular disease. 33 An educational level of 10-12 years, being native Swede and the presence of psychiatric disorder increased the likelihood of reaching target blood pressure in women.…”

Section: Discussionmentioning

confidence: 99%

“…12 In Sweden, patients born abroad have the lowest persistence to antihypertensive treatment. 13 If there is a difference in prescription pattern according to educational level and country of birth in women and men is not known. Furthermore, whether educational level and country of birth influence achieved target blood pressure differently in women and men is not known.…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database (SPCCD)

et al. 2014

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The reasons why women and men are treated with different antihypertensive drugs are not clear. Whether socioeconomic factors influence prescription patterns and blood pressure control differently in women and men has not been investigated. This cross-sectional study performed in a cohort of hypertensive patients from the Swedish Primary Care Cardiovascular Database (SPCCD) examined the influence of educational level, country of birth, gender and concomitant psychiatric disorder on prescription pattern and blood pressure control in 40,825 hypertensive patients. Men were more often than women treated with calcium channel blocker and angiotensin-converting enzyme inhibitor (ACEI), irrespective of education, country of birth and psychiatric disorder. Educational level influenced the prescription pattern to some extent, where the gender differences were reduced in patients with a higher educational level. In women, but not in men, high educational level and concomitant psychiatric disorder were associated with a higher proportion reaching target blood pressure. The predominant use of ACEI and calcium channel blockers in men is not influenced by educational level, country of birth or psychiatric disorder. Thus other explanations must be considered such as gender differences in side effects. Educational level seems to have a greater impact on reaching target blood pressure in women compared with men.

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“…In the aftermath of this study, the question of antihypertensive drug adherence has again attained much interest. It has been shown that the persistence to antihypertensive treatment for newly diagnosed patients with hypertension decrease by 26% after 1 year . It has also been described that 50% off apparently treatment‐resistant hypertensive patients have low medication adherence as the cause of TRH .…”

Section: Introductionmentioning

confidence: 99%

Drug adherence in treatment resistant and in controlled hypertension—Results from the Swedish Primary Care Cardiovascular Database (SPCCD)

Holmqvist

Boström

Kahan

et al. 2018

Pharmacoepidemiology and Drug

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Persistence to antihypertensive drug treatment in Swedish primary healthcare

Abstract: Major determinants of discontinuation of antihypertensive drug treatment are male sex, young age, mild-to-moderate systolic blood pressure elevation, and birth outside of Sweden.

Cited by 53 publications

References 47 publications

Patient-related beliefs and adherence toward their medications among the adult hypertensive outpatients in Tanzania

Patient-related beliefs and adherence toward their medications among the adult hypertensive outpatients in Tanzania

Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database (SPCCD)

Drug adherence in treatment resistant and in controlled hypertension—Results from the Swedish Primary Care Cardiovascular Database (SPCCD)

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