Persistence of Porphyromonas gingivalis is a negative predictor in patients with moderate to severe periodontitis after nonsurgical periodontal therapy

mentioning

confidence: 99%

Microbiologic Response to Periodontal Therapy and Multivariable Prediction of Clinical Outcome

Mombelli

Almaghlouth

Cancela

et al. 2017

“…The importance of the intention to reduce as good as possible the bacterial load of P. gingivalis results from the study of Eick et al where the quality of the improvement after SRP is in function of the eradication of P. gingivalis in the subgingival bacterial biofilm. 28 The present mono-center study was associated with limitations. The sample size is low, a multicenter approach is suggested to confirm the outcome of the study.…”

Section: Discussionmentioning

confidence: 87%

“…After SRP Eick et al. found a reduction of 79% or 40% of sites with PD ≥5 mm for high or low responder after SRP …”

Section: Discussionmentioning

confidence: 99%

“…The importance of the intention to reduce as good as possible the bacterial load of P. gingivalis results from the study of Eick et al. where the quality of the improvement after SRP is in function of the eradication of P. gingivalis in the subgingival bacterial biofilm …”

Section: Discussionmentioning

confidence: 99%

“…7,27 After SRP Eick et al found a reduction of 79% or 40% of sites with PD ≥5 mm for high or low responder after SRP. 28 Professional tooth cleaning improves the PD before SRP, but does not further improve the general outcome of the combined therapy (SRP with prior professional mechanical T A B L E 2 Clinical variables (mean ± SD) of the test group (two appointments of professional tooth cleaning before SRP) and control group (without professional tooth cleaning before SRP) at baseline (T0), 6 weeks before SRP (T1) and three (T2) and 6 months (T3) tooth cleaning). Hence for the outcome of the SRP motivation and instruction of the patient for enhanced continuous self-performed mechanical plaque control is of importance.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Professional tooth cleaning prior to non‐surgical periodontal therapy: A randomized clinical trial

Jentsch

Heusinger²,

Weickert³

et al. 2019

Self Cite

Background This study was aimed to investigate if professional oral prophylaxis before scaling and root planing (SRP) has an effect on the outcome of non‐surgical periodontal treatment in patients with chronic periodontitis. Methods Fifty‐two individuals with chronic periodontitis receiving non‐surgical periodontal therapy by SRP with (test) and without (control) two appointments of professional tooth cleaning but with motivation and instruction were monitored for clinical variables, four selected microorganisms and two biomarkers at baseline, before SRP as well as 3 and 6 months after SRP. Statistical analysis included non‐parametric tests for intra‐ and intergroup comparisons. Results Probing depth (PD), attachment level, bleeding on probing (BOP), and interproximal plaque index (API) were significantly improved in both groups 3 and 6 months after SRP. PD, BOP, API, and the number of sites with PD ≥5 mm were significantly lower in the test group than in the control group at the appointment immediately before SRP. Tannerella forsythia was significantly reduced in both groups at 3 and 6 months, Porphyromonas gingivalis only in the test group. Interleukin‐1β was significantly reduced in the control group 3 and 6 months after SRP, matrix metalloproteinase‐8 level decreased in the test group 3 months after SRP. There was no significant difference of any clinical and non‐clinical variable between both groups at 3 and 6 months after SRP. Conclusions Professional tooth cleaning before the SRP does not improve the clinical results of the SRP. It has no obvious long‐lasting effects on major periodontopathogens in the subgingival biofilm as well as on biomarkers in the gingival crevicular fluid after SRP.

Full‐mouth disinfection effects on gingival fluid calprotectin, osteocalcin, and N‐telopeptide of Type I collagen in severe periodontitis

Afacan

Çınarcık

Gürkan

et al. 2020

Background:To compare the effects of full-mouth disinfection (FMD) and fullmouth ultrasonic debridement (FMUD) on clinical, microbiological and biochemical parameters with conventional quadrant-wise scaling and root planning (Q-SRP) in severe chronic periodontitis. Methods:In the present prospective randomized controlled clinical trial with three parallel arms (#NCT04038801), 60 chronic periodontitis patients were randomly assigned to three study groups by a consecutive number in ascending order: FMD (n = 20), FMUD (n = 20), and Q-SRP (n = 20). All measurements and treatments were performed by the same investigator. At baseline, gingival crevicular fluid (GCF) and subgingival plaque were collected and clinical periodontal parameters were recorded. Ultrasonic debridement was completed within 24 hours in FMD and FMUD groups.Chlorhexidine gluconate was used for FMD. Q-SRP was performed by hand instruments per quadrant at 1-week-intervals. Clinical measurements and sampling were repeated at 1, 3, and 6 months after treatment. Real-time PCR was used for quantitative analysis of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Fusobacterium nucleatum, and total bacteria count. GCF Calprotectin, osteocalcin, and N-telopeptide of type I collagen (NTx) levels were analyzed by ELISA. The changes of GCF biomarker levels after treatment between groups were the primary outcomes. Results:No harm was observed. All treatment strategies resulted in significant improvements in all clinical parameters (P < 0.05), with no significant differences between study groups at all time-points (P ˃ 0.05). Aggregatibacter actinomycetemcomitans was significantly decreased in FMD compared to FMUD and Q-SRP at 6 months (P < 0.05). Although GCF NTx total amounts increased in all groups during 638© 2020 American Academy of Periodontology J Periodontol. 2020;91:638-650. wileyonlinelibrary.com/journal/jper AFACAN ET AL. 639the study period, this increase was less prominent in full-mouth groups at three time points after treatment (P < 0.05). Conclusions:Present results represent the short-term effects. Full-mouth treatment approaches offered limited beneficial effects on microbiological and biochemical parameters over quadrant-wise approach. All three treatment strategies can be recommended in the management of severe chronic periodontitis.