Persistence of mixed staphylococci assemblages following disinfection of hospital room surfaces

Sigler, Von; Hensley, Sandra

doi:10.1016/j.jhin.2012.12.009

Cited by 23 publications

(15 citation statements)

References 13 publications

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“…Quats only achieve a log 1 (90%) reduction of pathogenic bacteria. 13,28,29 Peracetic acid has been shown to get a log 2 (99%) reduction in pathogenic bacteria, but it was only shown to achieve only a log 1 (90%) reduction of C. difficile. 30,31 Also, peracetic acid use failed to decrease HAIs in a single hospital study.…”

Section: Journal Of Health Economics and Outcomes Researchmentioning

confidence: 99%

Use of a Launderable Bed Barrier and Antibiotic Stewardship to Decrease Hospital Onset Clostridioides difficile Infections in an Acute Care Hospital: A Retrospective Pre/Post Case Study

Hooker

Mallow

McKinney

et al. 2019

Journal of Health Economics and Outcomes Research

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Background: Hospital-onset Clostridioides difficile infection (HO-CDI) is a major source of morbidity and mortality. The objective of this research was to evaluate the reduction in HO-CDI through the use of a launderable bed barrier (BB) and an antibiotic stewardship program (ASP). Methods:A retrospective pre-post study was conducted at an acute care hospital in Kentucky. The preintervention period was September 2014 through March 2016. The BB and the ASP were introduced in April 2016, and the post-intervention period for this study ended September 2018. The rate of HO-CDI was calculated from the actual number of HO-CDI divided by the number of patient days each month. The number of defined daily doses of antibiotic therapy was measured each quarter. Hand disinfection compliance, length-of-stay (LOS), case mix index (CMI), and average age of patients were collected to control for confounding in the regression models.Results: There were 34 HO-CDIs and 42 672 patient days in the pre-intervention period and 31 HO-CDIs and 65 882 patient days in the post-intervention period. The average monthly count of HO-CDI was 1.79 (SD 1.51) and 1.03 (SD 0.96) during the pre-and post-periods, respectively. The average monthly rate (per 10 000 patient-days) was 7.94 (SD 6.30) in the pre-intervention period and 4.71 (SD 4.42) during the post-intervention period. The use of antibiotics decreased by 37% (p <0.0001) over the study period. The combination of the BB and the ASP were associated with a 59% (95% CI 36-96%, p 0.034) reduction in HO-CDI. Conclusions:The use of a launderable BB and the ASP were associated with a statistically and clinically significant reduction in HO-CDI in the acute care hospital setting.

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Section: Journal Of Health Economics and Outcomes Researchmentioning

confidence: 99%

Use of a Launderable Bed Barrier and Antibiotic Stewardship to Decrease Hospital Onset Clostridioides difficile Infections in an Acute Care Hospital: A Retrospective Pre/Post Case Study

Hooker

Mallow

McKinney

et al. 2019

Journal of Health Economics and Outcomes Research

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“…Another important point is that although the association of commonly used techniques is efficient in the environmental disinfection process, inefficient daily practice in bacterial combat is still used [20], and it is not enough to use a high performance disinfectant, Association with good procedures [17] as well as the adaptation of the correct routine described in the protocols [22,27]. According to Alfa et al [17], associated cleanliness compliance rates greater than 80% with disinfectant action resulting in lower rates of hospital infections by Clostridium difficile, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus.…”

Section: Discussionmentioning

confidence: 99%

Disinfectant Use in the Hospital Environment for Microorganisms Control

Oliveira¹,

Araújo²,

Garcia³

et al. 2017

J Bacteriol Parasitol

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Studies indicate that the hospital has an important role in transmission of various pathogens. To minimize the spread of these microorganisms in hospitals, they proposed various forms of disinfection, however diversity and effectiveness of these methods are varied. Thus, this study aimed to understand the associations and approaches that have been reported in recent years on microorganisms control by disinfectants in the hospital environment, thus enabling the search for new strategies and/or implementation of conducts already performed in other hospitals. In this article they performed a systematic review on the topic, in accordance with the preferred reporting items for systematic reviews and meta-analyzes-PRISMA. Articles were selected published between the years 2012-2016 present in the PubMed database. The data demonstrate that reviews many conventional methods may be flawed (10%), or may not be able to reduce the number of microorganisms (30%). The most frequently related microorganisms were Clostridium difficile (20%), methicillin-resistant Staphylococcus aureus (40%), or Enterococcus resistant to vancomycin (20%). There was no evidence statistical differences for a tendency to exchange the conventional methods, however the management was highlighted by 50% of the disinfection process. But our approach has enabled better understanding of mechanisms linked to environmental disinfection process of pathogenic microorganisms, thus pointing to coherent strategies in disinfection processes, which have benefits with the reduction of major causative agents of nosocomial infections and thus with decreasing nosocomial diseases.

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“…constitute an important part of the microbiota colonizing the hospital environment [38]. This is apparent even after routine daily cleaning or after adding copper to surfaces that are frequently touched in hospital settings [39, 40]. However, the cited reports do not include information about species identification or molecular epidemiology.…”

Section: Discussionmentioning

confidence: 99%

Colonization of patients, healthcare workers, and the environment with healthcare-associated Staphylococcus epidermidis genotypes in an intensive care unit: a prospective observational cohort study

et al. 2016

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BackgroundDuring the last decades, healthcare-associated genotypes of methicillin-resistant Staphylococcus epidermidis (HA-MRSE) have been established as important opportunistic pathogens. However, data on potential reservoirs on HA-MRSE is limited. The aim of the present study was to investigate the dynamics and to which extent HA-MRSE genotypes colonize patients, healthcare workers (HCWs) and the environment in an intensive care unit (ICU).MethodsOver 12 months in 2006–2007, swab samples were obtained from patients admitted directly from the community to the ICU and patients transferred from a referral hospital, as well as from HCWs, and the ICU environment. Patients were sampled every third day during hospitalization. Antibiotic susceptibility testing was performed according to EUCAST guidelines. Pulsed-field gel electrophoresis and multilocus sequence typing were used to determine the genetic relatedness of a subset of MRSE isolates.ResultsWe identified 620 MRSE isolates from 570 cultures obtained from 37 HCWs, 14 patients, and 14 environmental surfaces in the ICU. HA-MRSE genotypes were identified at admission in only one of the nine patients admitted directly from the community, of which the majority subsequently were colonized by HA-MRSE genotypes within 3 days during hospitalization. Almost all (89%) of HCWs were nasal carriers of HA-MRSE genotypes. Similarly, a significant proportion of patients transferred from the referral hospital and fomites in the ICU were widely colonized with HA-MRSE genotypes.ConclusionsPatients transferred from a referral hospital, HCWs, and the hospital environment serve as important reservoirs for HA-MRSE. These observations highlight the need for implementation of effective infection prevention and control measures aiming at reducing HA-MRSE transmission in the healthcare setting.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-2094-x) contains supplementary material, which is available to authorized users.

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Persistence of mixed staphylococci assemblages following disinfection of hospital room surfaces

Cited by 23 publications

References 13 publications

Use of a Launderable Bed Barrier and Antibiotic Stewardship to Decrease Hospital Onset Clostridioides difficile Infections in an Acute Care Hospital: A Retrospective Pre/Post Case Study

Use of a Launderable Bed Barrier and Antibiotic Stewardship to Decrease Hospital Onset Clostridioides difficile Infections in an Acute Care Hospital: A Retrospective Pre/Post Case Study

Disinfectant Use in the Hospital Environment for Microorganisms Control

Colonization of patients, healthcare workers, and the environment with healthcare-associated Staphylococcus epidermidis genotypes in an intensive care unit: a prospective observational cohort study

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