Persistence of IgM, IgG, and IgA Antibodies to Yersinia in Yersinia Arthritis

Granfors, Kaisa; Viljanen, Matti K.; Tiilikainen, A; Toivanen, Auli

doi:10.1093/infdis/141.4.424

Cited by 141 publications

(51 citation statements)

References 13 publications

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“…It would now seem that following a number of viral infections the specific IgM response is transient in contrast to a persisting IgA response, This pattern has been shown with rubella virus (6), hepatitis A virus (7), herpes simplex, varicella-zoster and cytomegalovirus (8) and with mumps and coxsackie B4 viruses in paediatric patients with insulin-dependent diabetes mellitus (9; 10). A similar pattern has been demonstrated in patients with severe arthritis due to Yersinia enterocolitica (11) and in those with toxoplasmosis (12). In the present study, using an assay of high sensitivity, our results with RR virus are in contrast to those summarized above in that IgM antibodies persist in a significant proportion of patients, whereas IgA antibodies do not.…”

Section: Discussionsupporting

confidence: 88%

Specific IgA antibody response in Ross River virus infection

1987

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Summary. Sera were collected over a period of several years from the onset of initial symptoms from 77 patients with Ross River virus infection. When tested for virus-specific IgA antibodies, using an enzymelinked immunosorbent assay {ELISA) based on antibody class capture, 245 out of 704 sera were antibodypositive. Although Ross River virus IgA antibodies were present in the serum of all patients soon after onset of symptoms, the IgA response was relatively short-lived in comparison with specific IgM antibodies. The resulls suggested that the detection of high levels of Ross River virus IgA antibodies was of potential value in differentiating between recent and past infection, especially in those patients with persisting IgM antibodies.

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Section: Discussionsupporting

confidence: 88%

Specific IgA antibody response in Ross River virus infection

1987

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“…The workers in occupations which involved close contact with swine had more frequently elevated Ig G class ant ibodies against these serotypes. The Ig G class is the type which stays elevated for the greatest length of time after yersinosis with no postinfectious arthritis (26 for the nonarthritis cases and 33 (85%) for the arthritis subjects (27). However, it is not known how long Ig G antibodies persist after entirely asymptomatic enteric infection.…”

Section: Resultsmentioning

confidence: 99%

Antibodies against Yersinia among farmers and slaughterhouse workers.

Seuri¹,

Granfors²

1992

Scand J Work Environ Health

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SEURI M, GRANFORS K. Ant ibod ies against Yersinia among farmer s and slaughterhouse workers . Scand J Work Environ Health 1992;18:128-132. Antibodies to immuno globulins (Ig) M, G, and A against Yersinia enterocolitica serotypes 0:3 , 0:5, 0:8, and 0 :9 and Yersinia pseudotuberculosis serotype s I and III were analyzed by enzyme immunoassay of the serum samples of 161 slaughterhouse workers, 147 pig farmer s, and 114 grain or berry farmer s. The crude risk ratio s for elevated serum antibody concentrations were calculated with the use of the grain and berr y farmers as the reference population. The risk for an elevated Yenterocolitica 0 :3 Ig G concentration was 3.0 (95070 confidence interval (95070 CI) 1.3-7.1) for the pig farmers and 1.8 (95070 CI 0.7-4.4) for the slaughterhouse workers and the respective risks for elevated Yenterocolitica 0:9 Ig G were 2.4 (95070 CI 1.1-5.5) and 1.7 (95070 CI 0.7-4.0) . Since these two serotypes are commonly associated with swine, the increased number of subjects with elevated antibody levels could be causally related to occupational contact with this animal.

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“…IgA antibodies against YopD develop in 90% of reactive arthritis cases (7,26,27). IgG antibodies develop against all outer membrane proteins of Yersinia; but they develop more frequently against YopE (23 kDa), YopB (41 kDa), YopD (35 kDa), and YopH (51 kDa) (8,11,21). IgG antibodies can persist longer in cases of reactive arthritis, but not as consistently as IgA antibodies.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Western Blot Method for the Detection of Yersinia Antibodies: Evidence of Serological Cross-Reactivity between Yersinia Outer Membrane Proteins and Borrelia burgdorferi

Rawlins

Gerstner

Hill

et al. 2005

Clin Vaccine Immunol

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Yersinia enterocolitica and Yersinia pseudotuberculosis have been identified as causative organisms of reactive arthritis in humans. We evaluated a Western blot assay which uses Yersinia outer membrane proteins as antigens for the detection of Yersinia antibodies as a replacement for the complement fixation (CF) assay. Clinical agreement, sensitivity, and specificity were determined by testing 19 positive and 21 negative serum samples by the CF assay, Western blot assay, and enzyme-linked immunosorbent assay (ELISA). The CF assay and ELISA were compared to the Western blot assay, which was the reference method used in this study. Sera with antibodies that could potentially cross-react with Yersinia were also tested by the Western blot assay. The agreement, sensitivity, and specificity of the CF method were 61%, 26%, and 95%, respectively; and those for the ELISA were 89%, 95%, and 82%, respectively. The prevalences of Yersinia antibodies in 50 healthy donors were 6% for immunoglobulin G (IgG), 2% for IgA, and 2% for IgM. Sera positive for Bartonella henselae, Brucella, Chlamydia pneumoniae, and Rickettsia rickettsii antibodies showed cross-reactivity by the Western blot assay. The highest cross-reactivity was observed with Borrelia burgdorferi; 5 of 11 (45%) specimens were cross-reactive by the IgM-specific assay. Overall, the Western blot assay performs acceptably and is more sensitive than the CF assay, warranting replacement of the CF assay in the laboratory. Due to the evidence of cross-reactivity, particularly with B. burgdorferi, which can cause an oligoarthritis similar to reactive arthritis, the diagnosis of reactive arthritis should be based on clinical findings and complete serologic analysis of the potential causative infectious pathogens.

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Persistence of IgM, IgG, and IgA Antibodies to Yersinia in Yersinia Arthritis

Cited by 141 publications

References 13 publications

Specific IgA antibody response in Ross River virus infection

Specific IgA antibody response in Ross River virus infection

Antibodies against Yersinia among farmers and slaughterhouse workers.

Evaluation of a Western Blot Method for the Detection of Yersinia Antibodies: Evidence of Serological Cross-Reactivity between Yersinia Outer Membrane Proteins and Borrelia burgdorferi

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