Persistence of Chromosomal Aberrations in Blood Lymphocytes of Testicular Cancer Patients

Abstract

Chromosomal aberrations and sister chromatid exchanges were examined in 45 patients with nonseminomatous testicular cancer at different times after the termination of vinblastine, cisplatin and bleomycin (VPB) therapy and in 22 age-matched healthy men and untreated testicular cancer patients. After 36 months, the frequency of unstable aberrations markedly decreased in peripheral blood lymphocytes of VPB-treated patients, however the persistence of aberrant cells even 75 months after the termination of treatment underlines the necessity of longer follow-up of VPB-treated patients in order to evaluate the relationship between their carcinogen sensitivity and the risk of second malignancies.

Mutagenic and Genotoxic Effects of cis-(Dichloro)tetraammineruthenium(III) Chloride on Human Peripheral Blood Lymphocytes

“…Cytostatic drug therapy is known to induce chromosome aberrations (CA) [24][25][26][27]. An increase in the frequency of CA in human blood lymphocytes has been reported to occur in cancer patients treated with alkylating agents [24,28].…”

Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

“…T h e hypothesis that genes may predispose to testicular cancer has not yet been verified. However, indications are found in familial aggregation and increased constitutional chromosomal instability (Gundy et al, 1990;van den Berg-de Ruiter et al, 1990). Structural abnormalities in the tumours have been found, of which i(12p) is the most common (Atkin and Baker, 1983;Castedo et al, 1989a, b).…”

A male phenotype (XY) hermaphrodite treated for seminoma, fathered a healthy child by IVF–ICSI technique

“…Male offspring might thus inherit their father's defect. A distinct increase in spontaneous chromosomal aberrations has been reported [18]. The chromosomal instability may be a factor in the development of malignancy in testicular tumours.…”