A male phenotype (XY) hermaphrodite treated for seminoma, fathered a healthy child by IVF–ICSI technique

Zayed, Faheem; Ghalayini, Ibrahim Fathi; Matalka, Ismail

doi:10.1007/s10815-008-9234-1

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Both previous cases reported singleton pregnancies. The first had a 46,XX/46,XY (Sugawara et al, 2005) and the second a 46,XY karyotype (Zayed et al, 2008). The current case is the third of such a success and the first achieving a normal twin pregnancy and delivery.…”

Section: Discussionmentioning

confidence: 60%

Successful monozygotic twin pregnancy fathered by a male 46,XY true hermaphrodite

Younis

Radin

Kerner

et al. 2011

Reproductive BioMedicine Online

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This report presents an unusual case of absolute non-obstructive azoospermia revealed to be a male 46,XY true hermaphrodite who was successfully treated to father healthy monozygotic twins. A 27-year-old infertile male with non-obstructive azoospermia previously underwent an unsuccessful testicular sperm extraction procedure and refused donor sperm insemination.Revising the patient’s old records revealed that he was born with ambiguous genitalia. He had a 46,XY karyotype and was raised as a male. During childhood he underwent ambiguous genitalia reconstruction, right orchiopexy and left salpingo-oophorectomy that revealed a gonadoblastoma. A new treatment was employed performing testicular fine needle aspiration leading successfully to a monozygotic twin pregnancy. As far as is known, this is the first reported case of healthy twins fathered by a male 46,XY true hermaphrodite.

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Section: Discussionmentioning

confidence: 60%

Successful monozygotic twin pregnancy fathered by a male 46,XY true hermaphrodite

Younis

Radin

Kerner

et al. 2011

Reproductive BioMedicine Online

View full text Add to dashboard Cite

show abstract

A successful second delivery outcome using refrozen thawed testicular sperm from an infertile male true hermaphrodite with a 46, XX/46, XY karyotype: case report

Sugawara¹,

Kimura²,

Araki³

2012

Human Cell

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We report a successful second delivery of a healthy infant fathered using refrozen thawed testicular sperm from an infertile male chimera. We also examined sex chromosome distribution of the seminiferous tubule. Intracytoplasmic sperm injection (ICSI) was performed using the remaining refrozen testicular sperm, which had been stored during the first treatment. Biopsied testicular cells were examined by fluorescence in situ hybridization (FISH) and the peripheral lymphocyte karyotype was tested using a G-band. Following ICSI, a second pregnancy was established, and a healthy girl was successfully delivered at 40 gestational weeks without complications. Although the husband's lymphocyte chromosomal analysis revealed a 46, XX [28]/46, XY [2] karyotype, the seminiferous tubule cells on histological examination by FISH were chimeric sex chromosome type XX [18]/XY [82]. In conclusion, this is a very rare case report of a successful subsequent delivery of a healthy infant (46, XX) from an infertile true hermaphrodite (46, XX/46, XY) using refrozen thawed testicular sperm. The seminiferous tubule cells' karyotype ratio differed from that of the lymphocytes.

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A male phenotype (XY) hermaphrodite treated for seminoma, fathered a healthy child by IVF–ICSI technique

Abstract: This is the first case report of a successful delivery of a healthy infant fathered by an infertile 46, XY true hermaphrodite who suffered from a seminoma. Once treated and cured, the couple had IVF and ICSI using frozen testicular sperm and had a healthy baby.

Cited by 2 publications

References 18 publications

Successful monozygotic twin pregnancy fathered by a male 46,XY true hermaphrodite

Successful monozygotic twin pregnancy fathered by a male 46,XY true hermaphrodite

A successful second delivery outcome using refrozen thawed testicular sperm from an infertile male true hermaphrodite with a 46, XX/46, XY karyotype: case report

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