Persistence of Brucella abortus strain 19 infection in adult cattle vaccinated with reduced doses

Effect of polymorphisms in the Slc11a1 coding region on resistance to brucellosis by macrophages in vitro and after challenge in two Bos breeds (Blanco Orejinegro and Zebu)

“…The only clear pathological symptom of this challenge was ocular irritation. Although B. abortus S19 can produce abortion in vaccinated and non-vaccinated adult cows and cause genital problems in adult bulls (Corner and Alton, 1981; Nicoletti et al , 1990; Chin, 2000; Moriyon et al , 2004), these effects were not observed here, possibly because this strain is not particularly pathogenic in the cattle breeds studied.…”

Vaccination with recombinant Semliki Forest virus particles expressing translation initiation factor 3 of Brucella abortus induces protective immunity in BALB/c mice

“…Therefore, they have been exploited to control brucellosis in domestic animals Confer et al, 1985). However, these vaccine preparations are far from ideal, since they exhibit several disadvantages, e.g., they are considered too virulent or unsafe for human use, and they can induce abortion in pregnant cattle (Corner and Alton 1981;Smith and Ficht, 1990;Palmer et al, 1996;Ashford et al, 2004). Hence, a vaccine that is not infectious for humans but remains able to stimulate strong protective responses is necessary to control brucellosis.…”

Evaluation of Brucella abortus DNA vaccine by expression of Cu–Zn superoxide dismutase antigen fused to IL-2

“…However, there is no safe or effective vaccine available for humans. The vaccine strains used for animals are considered virulent or unsafe for the human population (Ashford et al, 2004;Corner and Alton, 1981;Palmer et al, 1997;Young, 1983). Because Brucella is a facultative intracellular bacterium, resistance to B. abortus depends on acquired cell-mediated immunity (CMI) .…”